O64 Profiling germline and somatic mutations in consecutive early onset colorectal cancer cases in a European population
Oral Presentations, pp. A41.1–A41
Abstract
[Introduction] The incidence of early-age onset colorectal cancer (EOCRC), defined as CRC diagnosed before the age of 50, has been rising globally since the 1990s. Whilst high risk surveillance exists for selected patients, only ~16% of EOCRC may be attributed to a germline pathogenic variant. Identifying molecular profiles in EOCRC patients can enhance high-risk surveillance strategies and inform personalised oncological treatment. This study aims to characterise the real-world somatic and germline molecular profiles of consecutive patients with EOCRC across multiple European centres.
Authors 27
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London North West Healthcare NHS Trust · St Mark's Hospital
Affiliation as printed
The Centre for Familial Intestinal Cancer, St Mark’s Hospital, London Northwest Healthcare Trust, London, UK
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Affiliation as printed
Department of Surgery and Cancer, Imperial College London, London, UK
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London North West Healthcare NHS Trust · St Mark's Hospital
Affiliation as printed
The Centre for Familial Intestinal Cancer, St Mark’s Hospital, London Northwest Healthcare Trust, London, UK
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London North West Healthcare NHS Trust · St Mark's Hospital
Affiliation as printed
The Centre for Familial Intestinal Cancer, St Mark’s Hospital, London Northwest Healthcare Trust, London, UK
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Chelsea and Westminster Hospital NHS Foundation Trust
Affiliation as printed
Chelsea and Westminster NHS Trust, London, UK
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Chelsea and Westminster Hospital NHS Foundation Trust
Affiliation as printed
Chelsea and Westminster NHS Trust, London, UK
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Affiliation as printed
National Center for Hereditary Tumour Syndromes, University of Bonn, Bonn, Germany
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Affiliation as printed
National Center for Hereditary Tumour Syndromes, University of Bonn, Bonn, Germany
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Hospital Clínic de Barcelona · Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas · Consorci Institut D'Investigacions Biomediques August Pi I Sunyer · Universitat de Barcelona
Affiliation as printed
Department of Gastroenterology, Hospital Clínic de Barcelona, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS) Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), University of Barcelona, Barcelona, Spain
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Hospital Clínic de Barcelona · Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas · Consorci Institut D'Investigacions Biomediques August Pi I Sunyer · Universitat de Barcelona
Affiliation as printed
Department of Gastroenterology, Hospital Clínic de Barcelona, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS) Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), University of Barcelona, Barcelona, Spain
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Vall d'Hebron Hospital Universitari
Affiliation as printed
Department of Surgery, Vall d’Hebron University Hospital, Barcelona, Spain
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Humanitas University · IRCCS Humanitas Research Hospital
Affiliation as printed
Division of Colon and Rectal Surgery, Humanitas Research Hospital, Humanitas University, Rozzano, Italy
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Leiden University · Leiden University Medical Center
Affiliation as printed
Department of Pathology, Leiden University Medical Centre, Leiden, The Netherlands
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Hospital Universitario 12 De Octubre
Affiliation as printed
Department of Surgery, Hospital Universitario 12 de Octubre, Madrid, Spain
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MD Anderson Cancer Center Madrid
Affiliation as printed
Department of Surgery, Hospital MD Anderson, Madrid, Spain
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Hospital General Universitario Gregorio Marañón
Affiliation as printed
Department of Surgery, Hospital Universitario Gregorio Marañon, Madrid, Spain
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Affiliation as printed
Department of Surgery, Hospital del Mar, Barcelona, Spain
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Hospital Universitario Infanta Leonor
Affiliation as printed
Department of Surgery, Hospital Universitario Infanta Leonor, Madrid, Spain
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Affiliation as printed
Department of Surgery, Hospital Clínico San Carlos, Madrid, Spain
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Hospital Universitario Ramón y Cajal
Affiliation as printed
Department of Surgery, Hospital Universitario Ramon y Cajal, Madrid, Spain
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Hospital Universitario Fundación Alcorcón
Affiliation as printed
Department of Surgery, Hospital Universitario Fundación Alcorcón, Madrid, Spain
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Hospital Universitario General de Villalba
Affiliation as printed
Department of Surgery, Hospital Universitario General de Villalba, Madrid, Spain
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Hospital Universitario Fundación Jiménez Díaz
Affiliation as printed
Department of Surgery, Hospital Universitario Fundación Jiménez Díaz, Madrid, Spain
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Universidad de Salamanca · Instituto de Investigación Biomédica de Salamanca · Instituto de Biología Molecular y Celular del Cáncer de Salamanca
Affiliation as printed
Molecular Medicine Unit, Department of Medicine, Biomedical Research Institute of Salamanca (IBSAL), Institute of Molecular and Cellular Biology of Cancer (IBMCC), University of Salamanca-SACYL-CSIC, Salamanca, Spain
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Royal Marsden NHS Foundation Trust · Royal Marsden Hospital
Affiliation as printed
Cancer Genetics, Royal Marsden NHS Trust, London, UK
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Universidad de Salamanca · Instituto de Investigación Biomédica de Salamanca
Affiliation as printed
Institute of Biomedical Research of Salamanca, University Hospital of Salamanca, Salamanca, Spain
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London North West Healthcare NHS Trust · St Mark's Hospital · Imperial College London
Affiliation as printed
Department of Surgery and Cancer, Imperial College London, London, UK
The Centre for Familial Intestinal Cancer, St Mark’s Hospital, London Northwest Healthcare Trust, London, UK
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