Acquisition matters - how do scan parameters affect apparent diffusion coefficient estimates in pediatric rhabdomyosarcoma
Pediatric Radiology, vol. 55, pp. 1598–1610
Abstract
Abstract Background The apparent diffusion coefficient (ADC) derived from diffusion-weighted imaging (DWI) is a potential biomarker for treatment response in pediatric rhabdomyosarcoma. Due to its rarity, investigations into this marker require multicenter approaches, which can result in variability in acquisition parameters. Objective To evaluate the impact of different acquisition parameters on ADC estimates in a multicenter dataset of rhabdomyosarcoma patients. Materials and methods We included 114 pediatric and adolescent rhabdomyosarcoma patients from 22 treatment centers (195 scans). Median age: 6.0 years (0.3–21.8). We evaluated the impact of voxel size, (number of) b-values, and echo time on tumor ADC values. The effect of the highest b-value was separately investigated on a subset of scans with five or more b-values. Results We observed a large variability in key acquisition parameters in the overall cohort, and for individual imaging centers. No parameter showed a significant effect on ADC estimates of the whole cohort when corrected for multiple-comparisons. Decreasing the highest b-value within the same acquisition caused ADC to decrease on average by 2.8% per 100 s mm-2. Differing b-values between scans at diagnosis and treatment response yielded significant changes in the longitudinal ADC for each patient (P<0.05). Conclusion While we observed wide variation of acquisition parameters within a multicenter cohort, this did not lead to significant cross-sectional differences of tumor ADC. However, we found that modifying the highest b-value between baseline and follow-up can impact longitudinal ADC estimates. As such, we recommend the highest b-value to remain constant. This retrospective study was reviewed and approved by the Internal Review Board (UMC Utrecht, reference ID: 18-412). Graphical Abstract
Authors 40
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Cyrano Chatziantoniou corresponding
University Medical Center Utrecht · Princess Máxima Center
Affiliation as printed
Princess Máxima Center, Utrecht, Netherlands. c.chatziantoniou-3@umcutrecht.nl
University Medical Center Utrecht, Utrecht, Heidelberglaan 100, 3584 CX, Netherlands. c.chatziantoniou-3@umcutrecht.nl
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Roelof van Ewijk corresponding
Affiliation as printed
Princess Máxima Center, Utrecht, Netherlands. R.vanEwijk-2@prinsesmaximacentrum.nl
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Noah's Ark Children's Hospital for Wales
Affiliation as printed
Noah's Ark Children's Hospital for Wales, Cardiff, United Kingdom
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Affiliation as printed
University Hospital of Parma, Parma, Italy
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Affiliation as printed
University of Padua, Padova, Italy
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Centre Léon Bérard, Lyon, France
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Hospital Universitario Virgen del Rocío
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Hospital Universitario Virgen del Rocío, Seville, Spain
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Centre Hospitalier Universitaire de Rennes
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Centre Hospitalier Universitaire de Rennes, Rennes, France
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Vall d'Hebron Hospital Universitari
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Vall d'Hebron Hospital Universitari, Barcelona, Spain
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Affiliation as printed
Princess Máxima Center, Utrecht, Netherlands
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Queen Fabiola Children's University Hospital
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Queen Fabiola Children's University Hospital, Brussels, Belgium
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University Medical Center Utrecht
Affiliation as printed
University Medical Center Utrecht, Utrecht, Heidelberglaan 100, 3584 CX, Netherlands
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Fondazione IRCCS Istituto Nazionale dei Tumori
Affiliation as printed
Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
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Marta F. Fiocco Aachen
Leiden University Medical Center · Princess Máxima Center
Affiliation as printed
Leiden University Medical Center, Leiden, Netherlands
Princess Máxima Center, Utrecht, Netherlands
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Vall d'Hebron Hospital Universitari
Affiliation as printed
Vall d'Hebron Hospital Universitari, Barcelona, Spain
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Affiliation as printed
University of Padua, Padova, Italy
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Affiliation as printed
Oslo University Hospital, Oslo, Norway
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Wilhelmina Children's Hospital
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Wilhelmina Children's Hospital, Utrecht, Netherlands
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Noah's Ark Children's Hospital for Wales
Affiliation as printed
Noah's Ark Children's Hospital for Wales, Cardiff, United Kingdom
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Radboud University Medical Center
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Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands
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University Medical Center Utrecht
Affiliation as printed
University Medical Center Utrecht, Utrecht, Heidelberglaan 100, 3584 CX, Netherlands
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Affiliation as printed
Centre Eugène Marquis, Rennes, France
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Affiliation as printed
Royal Marsden Hospital, London, United Kingdom
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Great Ormond Street Hospital · Great Ormond Street Hospital for Children NHS Foundation Trust
Affiliation as printed
Great Ormond Street Hospital for Children NHS Foundation Trust, London, United Kingdom
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University Medical Center Utrecht · Princess Máxima Center
Affiliation as printed
Princess Máxima Center, Utrecht, Netherlands
University Medical Center Utrecht, Utrecht, Netherlands
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Affiliation as printed
Institut Gustave Roussy, Villejuif, France
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Affiliation as printed
Institut Gustave Roussy, Villejuif, France
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Fondazione IRCCS Istituto Nazionale dei Tumori
Affiliation as printed
Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
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Affiliation as printed
Institute Curie, Paris, France
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Affiliation as printed
Oslo University Hospital, Oslo, Norway
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Royal Marsden NHS Foundation Trust · Institute of Cancer Research · Royal Marsden Hospital
Affiliation as printed
Institute of Cancer Research, London, United Kingdom
Royal Marsden NHS Foundation Trust, London, United Kingdom
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Bambino Gesù Children's Hospital
Affiliation as printed
Bambino Gesù Children's Hospital, Rome, Italy
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Azienda Ospedaliera di Perugia
Affiliation as printed
Azienda Ospedaliera di Perugia, Perugia, Italy
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Affiliation as printed
Department of Hemato-Oncology and Cell Therapy, Santobono-Pausilipon Children's Hospital, Naples, Italy
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Universitair Ziekenhuis Leuven
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Universitair Ziekenhuis Leuven, Leuven, Belgium
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Amsterdam University Medical Centers · University of Amsterdam
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Department of Radiology and Nuclear Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands
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Università Cattolica del Sacro Cuore
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Catholic University of the Sacred Heart, Milan, Italy
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Hospital Infantil Universitario Niño Jesús
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Hospital Infantil Universitario Niño Jesús, Madrid, Spain
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Affiliation as printed
Princess Máxima Center, Utrecht, Netherlands
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University Medical Center Utrecht
Affiliation as printed
University Medical Center Utrecht, Utrecht, Heidelberglaan 100, 3584 CX, Netherlands
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