One-Two Punch: Combining Chemotherapy and Immunotherapy to Decrease Radiation Dose and Related Toxicity in Children and Adolescents with Nasopharyngeal Carcinoma
Clinical Cancer Research, vol. 31, pp. 3124–3132
Abstract
Nasopharyngeal carcinoma is rare in children and adolescents. Although radiation has been an essential component of treatment for this often-curable tumor, it can lead to severe side effects in survivors. Therefore, the reduction of radiation-related long-term effects by limiting radiation dose is a key clinical priority. Previous pediatric clinical trials by the Children's Oncology Group and the German Society of Pediatric Oncology and Hematology have treated patients with induction chemotherapy followed by radiation with concomitant chemotherapy and adjuvant immunotherapy with IFN, leading to excellent survival. These groups now take us forward into a new age of clinical trials using chemotherapy-immunotherapy induction with anti-PD-1 therapies followed by response-adapted, dose-reduced radiation with the goal of preserving outcomes while limiting late effects and morbidities.
Authors 16
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The University of Western Australia · The Kids Research Institute Australia · Princess Margaret Hospital for Children · Perth Children's Hospital
Affiliation as printed
1Department of Oncology, Perth Children’s Hospital, Perth, Australia
2WA Kids Cancer Center, The Kids Research Institute Australia, Perth, Australia
3The University of Western Australia, Perth, Australia
Perth Children's Hospital, Perth, Western Australia, Australia
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Columbia University Irving Medical Center
Affiliation as printed
4Department of Rehabilitation and Regenerative Medicine, New York-Presbyterian Columbia Irving Medical Center, New York, New York
Columbia University Medical Center, United States
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Affiliation as printed
6Columbia College, Columbia University, New York, New York
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Affiliation as printed
6Columbia College, Columbia University, New York, New York
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St. Jude Children's Research Hospital
Affiliation as printed
7Department of Oncology, St Jude Children’s Research Hospital, Memphis, Tennessee
8Department of Global Pediatric Medicine, St Jude Children’s Research Hospital, Memphis, Tennessee
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Affiliation as printed
9Cancer and Blood Disorders, Children’s Minnesota, Minneapolis, Minnesota
Children's Minnesota, Minneapolis, MN, United States
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The University of Texas Southwestern Medical Center
Affiliation as printed
10Department of Pediatrics, UT Southwestern Medical Center, Dallas, Texas
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Virginia Tech · Children's National · Carilion Roanoke Memorial Hospital · Carilion Clinic
Affiliation as printed
11Fralin Biomedical Research Institute, Virginia Polytechnic Institute and State University, Roanoke, Virginia
12Department of Internal Medicine, Virginia Tech Carilion School of Medicine, Roanoke, Virginia
13Brain and Tumor Institute, Children’s National Hospital, Washington, District of Columbia
14Center for Cancer & Immunology Research, Children’s National Hospital, Washington, District of Columbia
15Department of Radiation Oncology, Inova Schar Cancer Institute, Fairfax, Virginia
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St. Jude Children's Research Hospital
Affiliation as printed
16Department of Radiation Oncology, St Jude Children's Research Hospital, Memphis, Tennessee
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Tristan Römer Aachen Medical Faculty Center for Integrated Oncology 17Division of Pediatric Hematology
Affiliation as printed
17Division of Pediatric Hematology, Oncology and Stem Cell Transplantation, Center for Integrated Oncology, Medical Faculty, RWTH, Aachen, Germany
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Medizinische Hochschule Hannover
Affiliation as printed
18Department of Radiotherapy, Hannover Medical School, Hannover, Germany
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University of Southern California
Affiliation as printed
19Keck School of Medicine, University of Southern California, Los Angeles, California
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University of Pennsylvania · Children's Hospital of Philadelphia
Affiliation as printed
20Division of Oncology, Children’s Hospital of Philadelphia, University of Pennsylvania, Philadelphia, Pennsylvania
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Affiliation as printed
21Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut
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Affiliation as printed
17Division of Pediatric Hematology, Oncology and Stem Cell Transplantation, Center for Integrated Oncology, Medical Faculty, RWTH, Aachen, Germany
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Johns Hopkins University · Johns Hopkins Medicine
Affiliation as printed
22Division of Pediatric Oncology, Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland
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