Occupational Exposure to Asbestos and Mesothelioma Risk: A Protocol of Meta-Analysis and Systematic Literature Review in Germany

Asian Pacific Journal of Environment and Cancer, pp. 20250219

Abstract

Background: Occupational exposure to asbestos is a known risk factor for mesothelioma, a rare but deadly cancer with a prolonged latency period. This study focuses on the association between occupational asbestos exposure and mesothelioma risk within the German context, reflecting the country’s unique industrial legacy and regulatory framework. Methods: This protocol outlines a systematic meta-analysis and literature review targeting studies related to occupational asbestos exposure and mesothelioma risk in Germany. The review incorporates comprehensive searches of major databases, focusing on studies published in peer-reviewed journals. Data extraction will emphasize study characteristics, exposure assessment, and confounder adjustments. Quality assessment tools will evaluate study reliability and biases. Results: The meta-analysis aims to quantify mesothelioma risk linked to occupational asbestos exposure in Germany. The analysis will include pooled risk estimates adjusted for exposure levels, fiber types, and industry-specific contexts. Subgroup and sensitivity analyses will enhance the robustness of findings. Conclusion: The findings are expected to offer evidence-based insights into the risks of occupational asbestos exposure in Germany, informing health policies and strategies to mitigate the burden of asbestos-related diseases.

Authors 11

1. Mahdi Daraei

   Shahid Beheshti University · Shahid Beheshti University of Medical Sciences

   Affiliation as printed

   Medical School, Shahid Beheshti University of Medical Sciences, Tehran, Iran

2. Mohammad Javad Shahsavari

   Shahid Beheshti University · Shahid Beheshti University of Medical Sciences

   Affiliation as printed

   Medical School, Shahid Beheshti University of Medical Sciences, Tehran, Iran

3. Arian Elyasi Aachen Medical engineering

   FH Aachen

   Affiliation as printed

   Medical engineering, FH Aachen, Germany

4. Mahdiyeh Sabet

   Shahid Beheshti University · Shahid Beheshti University of Medical Sciences

   Affiliation as printed

   Medical School, Shahid Beheshti University of Medical Sciences, Tehran, Iran

5. Sourena Baghersemnani

   Shahid Beheshti University · Shahid Beheshti University of Medical Sciences

   Affiliation as printed

   Medical School, Shahid Beheshti University of Medical Sciences, Tehran, Iran

6. Dina Soltani Nezhad

   Shahid Beheshti University · Shahid Beheshti University of Medical Sciences

   Affiliation as printed

   Medical School, Shahid Beheshti University of Medical Sciences, Tehran, Iran

7. Yaser Soleimani

   Shahid Beheshti University · Shahid Beheshti University of Medical Sciences

   Affiliation as printed

   Medical School, Shahid Beheshti University of Medical Sciences, Tehran, Iran

8. Sana Mirghaffari

   Shahid Beheshti University · Shahid Beheshti University of Medical Sciences

   Affiliation as printed

   Medical School, Shahid Beheshti University of Medical Sciences, Tehran, Iran

9. Ramin Ghanbarnia

   Shahid Beheshti University · Shahid Beheshti University of Medical Sciences

   Affiliation as printed

   Medical School, Shahid Beheshti University of Medical Sciences, Tehran, Iran

10. Saeideh Karamian

    Shahid Beheshti University · Shahid Beheshti University of Medical Sciences

    Affiliation as printed

    Medical School, Shahid Beheshti University of Medical Sciences, Tehran, Iran

11. Alireza Mosavi Jarrahi

    Shahid Beheshti University · Shahid Beheshti University of Medical Sciences

    Affiliation as printed

    Cancer Research Centre, Shahid Beheshti University of Medical Sciences, Tehran, Iran