A fasting-mimicking diet programme reduces abdominal adipose tissue while preserving abdominal muscle mass in persons with type 2 diabetes

Nutrition Metabolism and Cardiovascular Diseases, vol. 35, pp. 104111

Abstract

BACKGROUND AND AIM: This study evaluated the effects of a fasting-mimicking diet (FMD) programme alongside usual care on abdominal visceral- (aVAT) and subcutaneous (aSAT) adipose tissue, and abdominal muscle area (aMA) in persons with type 2 diabetes in primary care. METHODS AND RESULTS: (95 % CI -4.6 to 1.4) in aMA compared to the control group. Changes in aVAT and aSAT were strongly associated with change in HbA1c and moderately with other metabolic parameters. CONCLUSIONS: A 12-month FMD programme reduced both aVAT and aSAT, while aMA remained unaffected compared to controls in persons with type 2 diabetes. The decline in aVAT and aSAT was associated with a reduction of several metabolic parameters, including HbA1c. A monthly FMD programme yields various health benefits in type 2 diabetes and appears to be a valuable treatment option as adjunct to usual care. TRIAL REGISTRATION: ClinicalTrials.gov: NCT03811587, 05-11-2018.

Authors 8

1. Marjolein P. Schoonakker Aachen Department of Public Health and Primary Care

   Leiden University Medical Center

   Affiliation as printed

   Department of Public Health and Primary Care, Leiden University Medical Center (LUMC), Leiden, the Netherlands. Electronic address: m.p.schoonakker@lumc.nl

2. Elske L. van den Burg Aachen Department of Public Health and Primary Care

   Leiden University Medical Center

   Affiliation as printed

   Department of Public Health and Primary Care, Leiden University Medical Center (LUMC), Leiden, the Netherlands

3. Petra G. van Peet Aachen Department of Public Health and Primary Care

   Leiden University Medical Center

   Affiliation as printed

   Department of Public Health and Primary Care, Leiden University Medical Center (LUMC), Leiden, the Netherlands

4. Saskia le Cessie Aachen Department of Clinical Epidemiology

   Leiden University Medical Center

   Affiliation as printed

   Department of Clinical Epidemiology, Leiden University Medical Center (LUMC), Leiden, the Netherlands

5. Eleanor Penny

   Perspectum Ltd. (United Kingdom)

   Affiliation as printed

   Perspectum Ltd, Oxford, United Kingdom

6. Mattijs Everard Numans Aachen Department of Public Health and Primary Care

   Leiden University Medical Center

   Affiliation as printed

   Department of Public Health and Primary Care, Leiden University Medical Center (LUMC), Leiden, the Netherlands

7. Hanno Pijl Aachen

   Leiden University Medical Center

   Affiliation as printed

   Department of Public Health and Primary Care, Leiden University Medical Center (LUMC), Leiden, the Netherlands; Department of Internal Medicine, Leiden University Medical Center (LUMC), Leiden, the Netherlands

8. Hildo J. Lamb Aachen Department of Radiology, Leiden University Medical Center

   Leiden University Medical Center

   Affiliation as printed

   Department of Radiology, Leiden University Medical Center (LUMC), Leiden, the Netherlands