Multicompartment Polyion Complex Micelles Based on Triblock Polypept(o)ides Mediate Efficient siRNA Delivery to Cancer‐Associated Fibroblasts for Antistromal Therapy of Hepatocellular Carcinoma (Adv. Mater. 41/2024)

Advanced Materials, vol. 36

Abstract

siRNA co-Delivery With a novel identified target of cancer-associated fibroblast-derived microfibrillar-associated protein 5 (MFAP-5), ABC-triblock copolymer based multicompartment polyion complex micelle (PICM) deliver siRNA against MFAP-5 and the cationic amphiphilic drug desloratadine simultaneously. The codelivery of desloratadine facilitates intracellular siRNA delivery, resulting in knockdown of MFAP-5 and significantly reduce tumor burden in a mice model of hepatocellular carcinoma. More details can be found in article number 2404784 by Heyang Zhang, Leonard Kaps, Matthias Barz, and co-workers.

Authors 20

1. Paul M. Schneider

   Johannes Gutenberg University Mainz · University Medical Center of the Johannes Gutenberg University Mainz

   Affiliation as printed

   Department of Dermatology University Medical Center of the Johannes Gutenberg‐University 55128 Mainz Germany

2. Heyang Zhang Aachen

   Leiden University

   Affiliation as printed

   Division of BioTherapeutics Leiden Academic Centre for Drug Research (LACDR) Leiden University Leiden 2333CC Netherlands

3. Leon Simić Aachen

   Leiden University · Johannes Gutenberg University Mainz · University Medical Center of the Johannes Gutenberg University Mainz

   Affiliation as printed

   Department of Dermatology University Medical Center of the Johannes Gutenberg‐University 55128 Mainz Germany

   Division of BioTherapeutics Leiden Academic Centre for Drug Research (LACDR) Leiden University Leiden 2333CC Netherlands

4. Barbara Schrörs

   Johannes Gutenberg University Mainz · University Medical Center of the Johannes Gutenberg University Mainz · Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg-Universität Mainz

   Affiliation as printed

   Biosampling Unit TRON gGmbH ‐ Translational Oncology at the University Medical Center of the Johannes Gutenberg University Freiligrathstr. 12 55131 Mainz Germany

5. Özlem Akilli‐Öztürk

   Johannes Gutenberg University Mainz · University Medical Center of the Johannes Gutenberg University Mainz · Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg-Universität Mainz

   Affiliation as printed

   Biosampling Unit TRON gGmbH ‐ Translational Oncology at the University Medical Center of the Johannes Gutenberg University Freiligrathstr. 12 55131 Mainz Germany

6. Lin Jian

   Max Planck Institute for Polymer Research

   Affiliation as printed

   Max Planck Institute for Polymer Research, Physics at Interphases Ackermannweg 10 55128 Mainz Germany

7. Feyza Durak

   Johannes Gutenberg University Mainz · University Medical Center of the Johannes Gutenberg University Mainz · Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg-Universität Mainz

   Affiliation as printed

   Biosampling Unit TRON gGmbH ‐ Translational Oncology at the University Medical Center of the Johannes Gutenberg University Freiligrathstr. 12 55131 Mainz Germany

8. Jenny Schunke

   Johannes Gutenberg University Mainz · University Medical Center of the Johannes Gutenberg University Mainz

   Affiliation as printed

   Department of Dermatology University Medical Center of the Johannes Gutenberg‐University 55128 Mainz Germany

9. Vanessa Bolduan

   Johannes Gutenberg University Mainz · University Medical Center of the Johannes Gutenberg University Mainz

   Affiliation as printed

   Department of Dermatology University Medical Center of the Johannes Gutenberg‐University 55128 Mainz Germany

10. Bram Bogaert

    Ghent University

    Affiliation as printed

    Ghent Research Group on Nanomedicines Laboratory of General Biochemistry and Physical Pharmacy Faculty of Pharmaceutical Sciences Ghent University Ghent 9000 Belgium

11. David Schwiertz Aachen

    Leiden University · Johannes Gutenberg University Mainz · University Medical Center of the Johannes Gutenberg University Mainz

    Affiliation as printed

    Department of Dermatology University Medical Center of the Johannes Gutenberg‐University 55128 Mainz Germany

    Division of BioTherapeutics Leiden Academic Centre for Drug Research (LACDR) Leiden University Leiden 2333CC Netherlands

12. Gabriela Giannina Schäfer Aachen

    Leiden University · Johannes Gutenberg University Mainz · University Medical Center of the Johannes Gutenberg University Mainz

    Affiliation as printed

    Department of Dermatology University Medical Center of the Johannes Gutenberg‐University 55128 Mainz Germany

    Division of BioTherapeutics Leiden Academic Centre for Drug Research (LACDR) Leiden University Leiden 2333CC Netherlands

13. Matthias Bros

    Johannes Gutenberg University Mainz · University Medical Center of the Johannes Gutenberg University Mainz

    Affiliation as printed

    Department of Dermatology University Medical Center of the Johannes Gutenberg‐University 55128 Mainz Germany

14. Stephan Grabbe

    Johannes Gutenberg University Mainz · University Medical Center of the Johannes Gutenberg University Mainz

    Affiliation as printed

    Department of Dermatology University Medical Center of the Johannes Gutenberg‐University 55128 Mainz Germany

15. Jörn Markus Schattenberg

    Universitätsklinikum des Saarlandes · Saarland University

    Affiliation as printed

    Department of Medicine II Saarland University Medical Center Saarland University 66421 Homburg Germany

16. Koen Raemdonck

    Ghent University

    Affiliation as printed

    Ghent Research Group on Nanomedicines Laboratory of General Biochemistry and Physical Pharmacy Faculty of Pharmaceutical Sciences Ghent University Ghent 9000 Belgium

17. Kaloian Koynov

    Max Planck Institute for Polymer Research

    Affiliation as printed

    Max Planck Institute for Polymer Research, Physics at Interphases Ackermannweg 10 55128 Mainz Germany

18. Mustafa Diken

    Johannes Gutenberg University Mainz · University Medical Center of the Johannes Gutenberg University Mainz · Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg-Universität Mainz

    Affiliation as printed

    Biosampling Unit TRON gGmbH ‐ Translational Oncology at the University Medical Center of the Johannes Gutenberg University Freiligrathstr. 12 55131 Mainz Germany

19. Leonard Kaps

    Johannes Gutenberg University Mainz · University Medical Center of the Johannes Gutenberg University Mainz · Universitätsklinikum des Saarlandes · Saarland University

    Affiliation as printed

    Department of Dermatology University Medical Center of the Johannes Gutenberg‐University 55128 Mainz Germany

    Department of Medicine II Saarland University Medical Center Saarland University 66421 Homburg Germany

20. Matthias Barz Aachen

    Leiden University · Johannes Gutenberg University Mainz · University Medical Center of the Johannes Gutenberg University Mainz

    Affiliation as printed

    Department of Dermatology University Medical Center of the Johannes Gutenberg‐University 55128 Mainz Germany

    Division of BioTherapeutics Leiden Academic Centre for Drug Research (LACDR) Leiden University Leiden 2333CC Netherlands