Real-time mechanism-based interventions for daily alcohol challenges: Protocol for ecological momentary assessment and intervention
Digital Health, vol. 11, pp. 20552076241311731
Abstract
Background: Advancing evidence-based, tailored interventions for substance use disorders (SUDs) requires understanding temporal directionality while upholding ecological validity. Previous studies identified loneliness and craving as pivotal factors associated with alcohol consumption, yet the precise directionality of these relationships remains ambiguous. Objective: This study aims to establish a smartphone-based real-life intervention platform that integrates momentary assessment and intervention into everyday life. The platform will explore the temporal directionality of contextual influences on alcohol use among individuals experiencing loneliness and craving. Methods: We will target 180 individuals aged 18 to 70 in Germany who report loneliness, alcohol cravings, and meet risk or binge drinking criteria (over 14 standard drinks per week or five drinks in a single day for males, and over seven drinks per week or four drinks in a single day for females). Using a Within-Person-Encouragement-Design and Just-In-Time-Adaptive-Interventions, we will manipulate the contexts of loneliness and alcohol craving with cognitive reappraisal and physical activity interventions against a control condition (working memory task). Results: Recruitment started in June 2024, with data collection and processing expected by June 2027. Conclusion: Our real-life intervention platform endeavors to serve as a robust tool for discerning the directionality of the effects from time series data in everyday life influences on alcohol use for the future study. Ultimately, it will pave the way for low-threshold prevention, clinical treatment, and therapy to target diverse contexts of everyday life in SUD. Trial registration: German Clinical Trials Register DRKS00033133.
Authors 29
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Shuyan Liu corresponding
Deutsches Zentrum für Psychische Gesundheit · Charité - Universitätsmedizin Berlin
Affiliation as printed
Department of Psychiatry and Psychotherapy (Campus Charité Mitte), Charité—Universitätsmedizin Berlin, Berlin, Germany
German Center for Mental Health (DZPG), Partner Sites Berlin/Potsdam and Heidelberg/Mannheim/Ulm, Germany
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Charité - Universitätsmedizin Berlin
Affiliation as printed
Department of Psychiatry and Psychotherapy (Campus Charité Mitte), Charité—Universitätsmedizin Berlin, Berlin, Germany
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Heidelberg University · Central Institute of Mental Health · Medizinische Fakultät Mannheim
Affiliation as printed
Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, Mannheim, Germany
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Affiliation as printed
Department of Sports and Health Sciences, University of Potsdam, Potsdam, Germany
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Heidelberg University · Central Institute of Mental Health · Medizinische Fakultät Mannheim · Deutsches Zentrum für Psychische Gesundheit
Affiliation as printed
Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health (CIMH), Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany
German Center for Mental Health (DZPG), Partner Sites Berlin/Potsdam and Heidelberg/Mannheim/Ulm, Germany
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Heidelberg University · Central Institute of Mental Health · Medizinische Fakultät Mannheim · Deutsches Zentrum für Psychische Gesundheit
Affiliation as printed
Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany
German Center for Mental Health (DZPG), Partner Sites Berlin/Potsdam and Heidelberg/Mannheim/Ulm, Germany
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Technische Universität Dresden
Affiliation as printed
University Neuropsychology Center (UNC), TU Dresden, Dresden, Germany
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University of Würzburg · Universitätsklinikum Würzburg · Technische Universität Dresden
Affiliation as printed
Addiction Research, Institute for Clinical Psychology and Psychotherapy, Faculty of Psychology, Technische Universität Dresden, Dresden, Germany
Department of Child and Adolescent Psychiatry, Psychotherapy and Psychosomatics, University Hospital and University Würzburg, Wurzburg, Germany
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Karlsruhe Institute of Technology · Heidelberg University · Central Institute of Mental Health · Medizinische Fakultät Mannheim · Deutsches Zentrum für Psychische Gesundheit
Affiliation as printed
Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, Mannheim, Germany
German Center for Mental Health (DZPG), Partner Sites Berlin/Potsdam and Heidelberg/Mannheim/Ulm, Germany
Institute of Sports and Sports Science, Karlsruhe Institute of Technology, Karlsruhe, Germany
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Technische Universität Dresden
Affiliation as printed
Addiction Research, Institute for Clinical Psychology and Psychotherapy, Faculty of Psychology, Technische Universität Dresden, Dresden, Germany
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Heidelberg University · Central Institute of Mental Health · Medizinische Fakultät Mannheim
Affiliation as printed
Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, Mannheim, Germany
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Karlsruhe Institute of Technology
Affiliation as printed
Institute of Sports and Sports Science, Karlsruhe Institute of Technology, Karlsruhe, Germany
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Deutsches Zentrum für Psychische Gesundheit · Charité - Universitätsmedizin Berlin
Affiliation as printed
Department of Psychiatry and Psychotherapy (Campus Charité Mitte), Charité—Universitätsmedizin Berlin, Berlin, Germany
German Center for Mental Health (DZPG), Partner Sites Berlin/Potsdam and Heidelberg/Mannheim/Ulm, Germany
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Heidelberg University · Central Institute of Mental Health · Medizinische Fakultät Mannheim
Affiliation as printed
Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health (CIMH), Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany
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Affiliation as printed
Department of Sports and Health Sciences, University of Potsdam, Potsdam, Germany
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Heidelberg University · Central Institute of Mental Health · Medizinische Fakultät Mannheim · Deutsches Zentrum für Psychische Gesundheit
Affiliation as printed
Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health (CIMH), Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany
German Center for Mental Health (DZPG), Partner Sites Berlin/Potsdam and Heidelberg/Mannheim/Ulm, Germany
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University of Zurich · Erasmus University Rotterdam
Affiliation as printed
Department of Psychology, Education and Child Studies, Erasmus University Rotterdam, Rotterdam, The Netherlands
Healthy Longevity Center, University of Zurich, Zurich, Switzerland
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Heidelberg University · Central Institute of Mental Health · Medizinische Fakultät Mannheim · Deutsches Zentrum für Psychische Gesundheit
Affiliation as printed
Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, Mannheim, Germany
German Center for Mental Health (DZPG), Partner Sites Berlin/Potsdam and Heidelberg/Mannheim/Ulm, Germany
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Andreas Neubauer Aachen
Affiliation as printed
RWTH Aachen University, Aachen, Germany
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University of Potsdam · Deutsches Zentrum für Psychische Gesundheit
Affiliation as printed
Department of Sports and Health Sciences, University of Potsdam, Potsdam, Germany
German Center for Mental Health (DZPG), Partner Sites Berlin/Potsdam and Heidelberg/Mannheim/Ulm, Germany
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Technische Universität Dresden
Affiliation as printed
Addiction Research, Institute for Clinical Psychology and Psychotherapy, Faculty of Psychology, Technische Universität Dresden, Dresden, Germany
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Center for Information Services and High Performance Computing · Technische Universität Dresden
Affiliation as printed
Center for Information Services and High Performance Computing (ZIH), Technische Universität Dresden, Dresden, Germany
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Heidelberg University · Central Institute of Mental Health · Medizinische Fakultät Mannheim · Deutsches Zentrum für Psychische Gesundheit
Affiliation as printed
German Center for Mental Health (DZPG), Partner Sites Berlin/Potsdam and Heidelberg/Mannheim/Ulm, Germany
Institute of Psychopharmacology, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany
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Charité - Universitätsmedizin Berlin
Affiliation as printed
Department of Psychiatry and Psychotherapy (Campus Charité Mitte), Charité—Universitätsmedizin Berlin, Berlin, Germany
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Heidelberg University · Central Institute of Mental Health · Medizinische Fakultät Mannheim · Deutsches Zentrum für Psychische Gesundheit
Affiliation as printed
Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, Mannheim, Germany
German Center for Mental Health (DZPG), Partner Sites Berlin/Potsdam and Heidelberg/Mannheim/Ulm, Germany
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Deutsches Zentrum für Psychische Gesundheit · Charité - Universitätsmedizin Berlin
Affiliation as printed
Department of Psychiatry and Psychotherapy (Campus Charité Mitte), Charité—Universitätsmedizin Berlin, Berlin, Germany
German Center for Mental Health (DZPG), Partner Sites Berlin/Potsdam and Heidelberg/Mannheim/Ulm, Germany
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University of Würzburg · Universitätsklinikum Würzburg · Technische Universität Dresden
Affiliation as printed
Addiction Research, Institute for Clinical Psychology and Psychotherapy, Faculty of Psychology, Technische Universität Dresden, Dresden, Germany
Department of Child and Adolescent Psychiatry, Psychotherapy and Psychosomatics, University Hospital and University Würzburg, Wurzburg, Germany
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Affiliation as printed
Department of eHealth and Sports Analytics, Faculty of Sport Science, Ruhr-University Bochum, Bochum, Germany
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Markus Reichert corresponding
University of Salzburg · Heidelberg University · Central Institute of Mental Health · Medizinische Fakultät Mannheim · Ruhr University Bochum
Affiliation as printed
Department for Sport and Exercise Science, Paris Lodron University Salzburg, Salzburg, Austria
Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, Mannheim, Germany
Department of eHealth and Sports Analytics, Faculty of Sport Science, Ruhr-University Bochum, Bochum, Germany
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