Sample size estimation for task-related functional MRI studies using Bayesian updating

Developmental Cognitive Neuroscience, vol. 71, pp. 101489

Abstract

Task-related functional MRI (fMRI) studies need to be properly powered with an adequate sample size to reliably detect effects of interest. But for most fMRI studies, it is not straightforward to determine a proper sample size using power calculations based on published effect sizes. Here, we present an alternative approach of sample size estimation with empirical Bayesian updating. First, this method provides an estimate of the required sample size using existing data from a similar task and similar region of interest. Using this estimate researchers can plan their research project, and report empirically determined sample size estimations in their research proposal or pre-registration. Second, researchers can expand the sample size estimations with new data. We illustrate this approach using four existing fMRI data sets where Cohen's d is the effect size of interest for the hemodynamic response in the task condition of interest versus a control condition, and where a Pearson correlation between task effect and age is the covariate of interest. We show that sample sizes to reliably detect effects differ between various tasks and regions of interest. We provide an R package to allow researchers to use Bayesian updating with other task-related fMRI studies.

Authors 4

1. Eduard T. Klapwijk

   Erasmus University Rotterdam

   Affiliation as printed

   Erasmus University Rotterdam, Netherlands. Electronic address: et.klapwijk@gmail.com

2. Joran Jongerling

   Tilburg University

   Affiliation as printed

   Tilburg University, Netherlands

3. Herbert Hoijtink

   Utrecht University

   Affiliation as printed

   Utrecht University, Netherlands

4. Eveline A. Crone Aachen

   Leiden University · Erasmus University Rotterdam

   Affiliation as printed

   Erasmus University Rotterdam, Netherlands; Leiden University, Netherlands