Chronic pancreatitis

The Lancet, vol. 404, pp. 2605–2618

Abstract

Chronic pancreatitis is a progressive fibroinflammatory disease primarily caused by a complex interplay of environmental and genetic risk factors. It might result in pancreatic exocrine and endocrine insufficiency, chronic pain, reduced quality of life, and increased mortality. The diagnosis is based on the presence of typical symptoms and multiple morphological manifestations of the pancreas, including pancreatic duct stones and strictures, parenchymal calcifications, and pseudocysts. Management of chronic pancreatitis consists of prevention and treatment of complications, requiring a multidisciplinary approach focusing on lifestyle modifications, exocrine insufficiency, nutritional status, bone health, endocrine insufficiency, pain management, and psychological care. To optimise clinical outcomes, screening for complications and evaluation of treatment efficacy are indicated in all patients with chronic pancreatitis.

Authors 6

1. Naomi D. E. Thierens

   Radboud University Nijmegen · Radboud University Medical Center · St. Antonius Ziekenhuis

   Affiliation as printed

   Department of Gastroenterology and Hepatology, Radboud University Medical Center, Nijmegen, Netherlands; Department of Research and Development, St Antonius Hospital, Nieuwegein, Netherlands. Electronic address: naomi.thierens@radboudumc.nl

2. Robert C. Verdonk

   St. Antonius Ziekenhuis

   Affiliation as printed

   Department of Gastroenterology and Hepatology, St Antonius Hospital, Nieuwegein, Netherlands

3. Matthias J. Löhr

   Karolinska University Hospital

   Affiliation as printed

   Department of Upper Abdominal Diseases, Karolinska University Hospital, Stockholm, Sweden

4. Hjalmar C. van Santvoort

   University Medical Center Utrecht · St. Antonius Ziekenhuis

   Affiliation as printed

   Department of Surgery, St Antonius Hospital, Nieuwegein, Netherlands; Department of Surgery, University Medical Center Utrecht, Utrecht, Netherlands

5. Stefan A.W. Bouwense

   Maastricht University Medical Centre · Maastricht University

   Affiliation as printed

   Department of Surgery, Maastricht University Medical Center+, Maastricht, Netherlands

6. Jeanin Elise van Hooft Aachen Department of Gastroenterology and Hepatology

   Leiden University Medical Center

   Affiliation as printed

   Department of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, Netherlands