Allogeneic Hematopoietic Stem Cell Transplantation in Refractory Multiple Myeloma—A Retrospective Multicenter Analysis
European Journal Of Haematology, vol. 114, pp. 423–428
Abstract
A growing list of therapies available for patients with multiple myeloma (MM) results in deep response rates, but eventually almost all patients relapse. Allogeneic hematopoietic cell transplantation (allo-SCT) is a familiar approach for MM, but responses are often short and side effects burdensome. Simultaneously, allo-SCT provides a unique platform on which novel immune therapies can be employed to improve clinical outcomes. Our work describes the characteristics and outcomes of 128 refractory myeloma patients who underwent allo-SCT at five German centers between 2010 and 2021. The median number of therapies before the transplant was 6. With a median follow-up of 6, 4 years, the median progression-free survival and overall survival were 7 and 19 months, respectively. NRM was 28% after 6 years. OS and PFS were 61% and 45% at 1 year, 49% and 34% at 2 years, and 38% and 25% at 6 years. Achieving a CR before transplant was the single most significant variable before transplant. Allo-SCT yet remains an option for fit patient's refractory to all other treatments available. It is potentially curative for a subset of patients. Finding the characteristics of patients with durable remissions is key to sparing unnecessary toxicity for those unlikely to benefit.
Authors 11
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Heinrich Heine University Düsseldorf
Affiliation as printed
Department of Hematology, Oncology and Clinical Immunology Heinrich Heine University Düsseldorf Germany
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Heinrich Heine University Düsseldorf
Affiliation as printed
Department of Hematology, Oncology and Clinical Immunology Heinrich Heine University Düsseldorf Germany
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Essen University Hospital · University of Duisburg-Essen
Affiliation as printed
University Duisburg‐Essen, University Hospital Essen, Stem Cell Transplant Germany
University Duisburg-Essen, University Hospital Essen, Stem Cell Transplant, Germany
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Affiliation as printed
University Hospital Aachen, Medical Clinic IV, Stem Cell Transplantation Aachen Germany
University Hospital Aachen, Medical Clinic IV, Stem Cell Transplantation, Aachen, Germany
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Affiliation as printed
Center for Integrated Oncology Aachen Bonn Cologne Düsseldorf (CIO ABCD) Germany
Department of Hematology, Oncology, Stem Cell Transplantation, Immune and Cell Therapy, Clinical Immunology and Rheumatology, University Hospital Bonn Bonn Germany
Department of Hematology, Oncology, Stem Cell Transplantation, Immune and Cell Therapy, Clinical Immunology and Rheumatology, University Hospital Bonn, Bonn, Germany
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Affiliation as printed
Center for Integrated Oncology Aachen Bonn Cologne Düsseldorf (CIO ABCD) Germany
Department of Hematology, Oncology, Stem Cell Transplantation, Immune and Cell Therapy, Clinical Immunology and Rheumatology, University Hospital Bonn Bonn Germany
Department of Hematology, Oncology, Stem Cell Transplantation, Immune and Cell Therapy, Clinical Immunology and Rheumatology, University Hospital Bonn, Bonn, Germany
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University of Cologne · University Hospital Cologne
Affiliation as printed
Department I of Internal Medicine Medical Faculty and University Hospital of Cologne, University of Cologne Köln Germany
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University of Cologne · University Hospital Cologne
Affiliation as printed
Department I of Internal Medicine Medical Faculty and University Hospital of Cologne, University of Cologne Köln Germany
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University of Cologne · University Hospital Cologne
Affiliation as printed
Department I of Internal Medicine Medical Faculty and University Hospital of Cologne, University of Cologne Köln Germany
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University of Cologne · University Hospital Cologne
Affiliation as printed
Department I of Internal Medicine Medical Faculty and University Hospital of Cologne, University of Cologne Köln Germany
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University of Cologne · University Hospital Cologne
Affiliation as printed
Department I of Internal Medicine Medical Faculty and University Hospital of Cologne, University of Cologne Köln Germany
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