Four-factor Prothrombin Complex Concentrate Use for Bleeding Management in Adult Trauma

Anesthesiology, vol. 142, pp. 351–363

Abstract

The clinical use of four-factor prothrombin complex concentrate in adult trauma patients at risk of bleeding is supported by evidence for urgent reversal of oral anticoagulants but is controversial in acquired traumatic coagulopathy.

Authors 7

1. Lidia Mora

   Universitat Autònoma de Barcelona

   Affiliation as printed

   Department of Anesthesiology, Intensive Care and Pain Clinic, Vall d’Hebron Trauma, Rehabilitation and Burns Hospital, Autonomous University of Barcelona, Barcelona, Spain

   1Department of Anesthesiology, Intensive Care and Pain Clinic, Vall d’Hebron Trauma, Rehabilitation and Burns Hospital, Autonomous University of Barcelona, Barcelona, Spain

2. Marc Maegele

   Witten/Herdecke University

   Affiliation as printed

   Department for Trauma and Orthopedic Surgery, Cologne–Merheim Medical Center, Witten/Herdecke University, Campus Cologne–Merheim, Cologne, Germany

   2Department for Trauma and Orthopedic Surgery, Cologne–Merheim Medical Center, Witten/Herdecke University, Campus Cologne–Merheim, Cologne, Germany

3. Oliver Grottke Aachen Department of Anesthesiology, Rhenish–Westphalian Technical University 3Department of Anesthesiology

   Universitätsklinikum Aachen · RWTH Aachen University

   Affiliation as printed

   Department of Anesthesiology, Rhenish–Westphalian Technical University, Aachen University Hospital, Aachen, Germany

   3Department of Anesthesiology, Rhenish–Westphalian Technical University, Aachen University Hospital, Aachen, Germany

4. Andreas Koster

   Ruhr University Bochum

   Affiliation as printed

   Clinic for Anesthesiology and Interdisciplinary Intensive Care Medicine, Sana Heart Center Cottbus, Cottbus, Germany; Ruhr University of Bochum, Bochum, Germany

   4Clinic for Anesthesiology and Interdisciplinary Intensive Care Medicine, Sana Heart Center Cottbus, Cottbus, Germany; Ruhr University of Bochum, Bochum, Germany

5. Philipp Stein

   Kantonsspital St. Gallen

   Affiliation as printed

   Division of Anesthesiology, Hospital Linth, Kantonsspital St. Gallen, St. Gallen, Switzerland

   5Division of Anesthesiology, Hospital Linth, Kantonsspital St. Gallen, St. Gallen, Switzerland

6. Jerrold H. Levy

   Duke University · Duke Medical Center

   Affiliation as printed

   Department of Anesthesiology, Critical Care, and Surgery, Duke University School of Medicine, Durham, North Carolina

   6Department of Anesthesiology, Critical Care, and Surgery, Duke University School of Medicine, Durham, North Carolina

7. Gabor Erdoes

   University of Bern · University Hospital of Bern

   Affiliation as printed

   Department of Anesthesiology and Pain Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland

   7Department of Anesthesiology and Pain Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland