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Radiotherapy in cutaneous lymphomas: Recommendations from the EORTC cutaneous lymphoma tumour group

European Journal of Cancer, vol. 212, pp. 115064

Abstract

The number of primary cutaneous lymphoma patients receiving low-dose radiotherapy is increasing, though controlled clinical trials defining the standard radiation dose for each specific entity have not yet been completed. Radiation oncologists are left with making highly individualized decisions that would be better enriched by additional clinical evidence. In this expert opinion, we aim to provide a clear recommendation to improve the current practice of radiation oncology. In addition, existing literature has been reviewed to develop recommendations for all types of primary cutaneous lymphoma. A prospective trial is urgently needed to identify the factors influencing patient outcomes following different radiation doses.

Authors 33

  1. Universitätsklinikum Gießen und Marburg · University Hospital Münster

    Affiliation as printed

    Radiation Oncology, University Hospital of Münster, Münster, Germany; Department of Radiation Oncology, UKGM Marburg, Marburg, Germany; Marburg Ion-Beam Therapy Center (MIT), Department of Radiation Oncology, UKGM Marburg, Marburg, Germany; University Cancer Center (UCT) Frankfurt-Marburg, Marburg, Frankfurt, Germany. Electronic address: khaled.elsayad@uk-gm.de

  2. Johannes Kepler University of Linz · Centre Hospitalier Universitaire Vaudois · University of Lausanne

    Affiliation as printed

    Department of Dermatology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland; University Institute and Clinic for Immunodermatology, Medical Faculty, Johannes Kepler University, Linz, Austria

  3. MSH Medical School Hamburg – University of Applied Sciences and Medical University · Helios Klinikum Krefeld

    Affiliation as printed

    Institute for Molecular Medicine, Medical School Hamburg, University of Applied Sciences and Medical University, Hamburg, Germany; Department of Dermatology, HELIOS Klinikum Krefeld, Krefeld, Germany, Medical School Hamburg, University of Applied Sciences and Medical University, Hamburg, Germany

  4. University Medical Centre Mannheim

    Affiliation as printed

    Department of Dermatology, Venereology and Allergology, University Medical Center Mannheim, Mannheim, Germany

  5. Universitätsklinikum St. Pölten · Karl Landsteiner University of Health Sciences

    Affiliation as printed

    Department of Dermatology and Venereology, University Hospital of St. Pölten, Karl Landsteiner University of Health Sciences, St. Pölten, Austria

  6. Johannes Wesling Klinikum Minden

    Affiliation as printed

    Department of Dermatology, Johannes Wesling Medical Centre, University of Bochum, Minden, Germany

  7. Comprehensive Cancer Center Vienna · Medical University of Vienna

    Affiliation as printed

    Department of Radiation Oncology, Comprehensive Cancer Center, Medical University Vienna, Austria

  8. Ghent University Hospital

    Affiliation as printed

    Department of Radiation Oncology, Ghent University Hospital, Belgium

  9. University of Antwerp

    Affiliation as printed

    Iridium Netwerk, University of Antwerp, Antwerp, Belgium

  10. Institut Curie

    Affiliation as printed

    Department of Radiation Oncology, Institut Curie, Hopital de Paris, France

  11. Charité - Universitätsmedizin Berlin

    Affiliation as printed

    Department of Dermatology, Charite - Universitaetsmedizin Berlin - Campus Mitte, Germany

  12. Hospital Universitario Quirónsalud Madrid · IDCQ Hospitales y Sanidad, S.L.U. · Universidad Europea de Madrid

    Affiliation as printed

    Department of Radiation Oncology, Quironsalud Madrid University Hospital, Madrid, Spain; Universidad Europea de Madrid, Faculty of Biomedical and Health Sciences, Spain

  13. University of Bern · University Hospital of Bern

    Affiliation as printed

    Department of Radiation Oncology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland

  14. Al-Azhar University

    Affiliation as printed

    Department of Clinical Oncology, Al Azhar University, Cairo, Egypt

  15. University Medical Center Groningen

    Affiliation as printed

    Department of Radiation Oncology, University Medical Center Groningen, the Netherlands

  16. National and Kapodistrian University of Athens · University General Hospital Attikon

    Affiliation as printed

    National and Kapodistrian University of Athens, 2nd Department of Dermatology and Venereology, Attikon General Hospital, University of Athens, Chaidari, Greece

  17. Affiliation as printed

    Department of Dermatology, University Hospital Birmingham, Birmingham, UK

  18. Leiden University Medical Center

    Affiliation as printed

    Head of Department of Dermatology, Leiden University Medical Center, the Netherlands

  19. Leiden University Medical Center

    Affiliation as printed

    Department of radiotherapy, Leiden University Medical Center, the Netherlands

  20. Inserm · Université Paris Cité · Hôpital Saint-Louis · HIPI - Immunologie humaine, physiopathologie et immunithérapie

    Affiliation as printed

    Department of Dermatology, Hopital Saint Louis, Université Paris Cité, INSERM U976, Paris, France

  21. Inserm · Université Paris Cité · Hôpital Saint-Louis · HIPI - Immunologie humaine, physiopathologie et immunithérapie

    Affiliation as printed

    APHP Department of Pathology, INSERM U976, University Paris Cité, Saint-Louis University Hospital, Paris, France

  22. University of Turin

    Affiliation as printed

    Department of Medical Sciences, Section of Dermatology, University of Turin, Turin, Italy

  23. Medical University of Vienna

    Affiliation as printed

    Department of Dermatology, Medical University of Vienna, Vienna, Austria

  24. University Hospital Zurich

    Affiliation as printed

    Kempf und Pfaltz Histologische Diagnostik, Affolternstrasse 56, CH-8050 Zurich, Switzerland; Department of Dermatology, University Hospital Zurich, CH-8091 Zurich, Switzerland

  25. King Fahd Medical City

    Affiliation as printed

    Department of Radiation Oncology, King Fahad Medical City, Riyadh, Saudi Arabia

  26. Universitätsklinikum Gießen und Marburg

    Affiliation as printed

    Department of Radiation Oncology, UKGM Marburg, Marburg, Germany; Marburg Ion-Beam Therapy Center (MIT), Department of Radiation Oncology, UKGM Marburg, Marburg, Germany; University Cancer Center (UCT) Frankfurt-Marburg, Marburg, Frankfurt, Germany

  27. National and Kapodistrian University of Athens

    Affiliation as printed

    Department of Radiation Oncology, National and Kapodistrian University of Athens, Athens, Greece

  28. Azienda Ospedaliero-Universitaria Careggi

    Affiliation as printed

    Department of Radiation Oncology, DAI Oncologia, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy

  29. Ludwig-Maximilians-Universität München

    Affiliation as printed

    Radiation Oncology, LMU University of Munich, 81388 Munich, Germany

  30. Heidelberg University · University Hospital Heidelberg

    Affiliation as printed

    Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg, Germany

  31. University Hospital Münster

    Affiliation as printed

    Radiation Oncology, University Hospital of Münster, Münster, Germany

  32. University of Manchester · The Christie Hospital

    Affiliation as printed

    Department of Clinical Oncology, Christie Hospital, University of Manchester, Manchester, United Kingdom

  33. University of Bern · University Hospital of Bern · Kantonsspital Aarau

    Affiliation as printed

    Department of Radiation Oncology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland; Department of Radiation Oncology, Cantonal Hospital Aarau, Aarau, Aargau, Switzerland

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References 90