Longitudinal development of resting-state functional connectivity in adolescents with and without internalizing disorders
Neuroscience Applied, vol. 3, pp. 104090
Abstract
Longitudinal studies using resting-state functional magnetic resonance imaging (rs-fMRI) focused on adolescent internalizing psychopathology are scarce and have mostly investigated standardized treatment effects on functional connectivity (FC) of the full amygdala. The role of amygdala subregions and large resting-state networks had yet to be elucidated, and treatment is in practice often personalized. Here, longitudinal FC development of amygdala subregions and whole-brain networks are investigated in a clinically representative sample. Treatment-naïve adolescents with clinical depression and comorbid anxiety who started care-as-usual (n = 23; INT) and healthy controls (n = 24; HC) participated in rs-fMRI scans and questionnaires at baseline (before treatment) and after three months. Changes between and within groups over time in FC of the laterobasal amygdala (LBA), centromedial amygdala (CMA) and whole-brain networks derived from independent component analysis (ICA) were investigated. Groups differed significantly in FC development of the right LBA to the postcentral gyrus and the left LBA to the frontal pole. Within INT, FC to the frontal pole and postcentral gyrus changed over time while changes in FC of the right LBA were also linked to symptom change. No significant interactions were observed when considering FC from CMA bilateral seeds or within ICA-derived networks. Results in this cohort suggest divergent longitudinal development of FC from bilateral LBA subregions in adolescents with internalizing disorders compared to healthy peers, possibly reflecting nonspecific treatment effects. Moreover, associations were found with symptom change. These results highlight the importance of differentiation of amygdala subregions in neuroimaging research in adolescents.
Authors 5
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Eline F. Roelofs Aachen Department of Psychiatry, Leiden University Medical Center LUMC Curium Department of Child and Adolescent Psychiatry Leiden Institute for Brain and Cognition
Leiden University · Leiden University Medical Center
Affiliation as printed
Department of Psychiatry, Leiden University Medical Center, Leiden, the Netherlands
LUMC-Curium, Department of Child and Adolescent Psychiatry, Leiden University Medical Center, Leiden, the Netherlands
Leiden Institute for Brain and Cognition, Leiden, the Netherlands
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Janna Marie Bas‐Hoogendam Aachen Department of Psychiatry, Leiden University Medical Center Developmental and Educational Psychology Institute of Psychology, Leiden University Leiden Institute for Brain and Cognition
Leiden University · Leiden University Medical Center
Affiliation as printed
Department of Psychiatry, Leiden University Medical Center, Leiden, the Netherlands
Developmental and Educational Psychology, Institute of Psychology, Leiden University, Leiden, the Netherlands
Leiden Institute for Brain and Cognition, Leiden, the Netherlands
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National Institutes of Health · The University of Texas Rio Grande Valley · National Institute of Mental Health
Affiliation as printed
Division of Human Genetics, School of Medicine, The University of Texas Rio Grande Valley, Brownsville, TX, United States
Section on Development and Affective Neuroscience (SDAN), Emotion and Development Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, United States
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Nic J.A. van der Wee Aachen Department of Psychiatry, Leiden University Medical Center Leiden Institute for Brain and Cognition
Leiden University · Leiden University Medical Center
Affiliation as printed
Department of Psychiatry, Leiden University Medical Center, Leiden, the Netherlands
Leiden Institute for Brain and Cognition, Leiden, the Netherlands
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Robert R. J. M. Vermeiren Aachen LUMC Curium Department of Child and Adolescent Psychiatry Leiden Institute for Brain and Cognition
Leiden University · Leiden University Medical Center
Affiliation as printed
LUMC-Curium, Department of Child and Adolescent Psychiatry, Leiden University Medical Center, Leiden, the Netherlands
Leiden Institute for Brain and Cognition, Leiden, the Netherlands
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