Development and validation of cardiometabolic risk predictive models based on LDL oxidation and candidate geromarkers from the MARK-AGE data
Mechanisms of Ageing and Development, vol. 222, pp. 111987
Abstract
The predictive value of the susceptibility to oxidation of LDL particles (LDLox) in cardiometabolic risk assessment is incompletely understood. The main objective of the current study was to assess its relationship with other relevant biomarkers and cardiometabolic risk factors from MARK-AGE data. A cross-sectional observational study was carried out on 1089 subjects (528 men and 561 women), aged 40-75 years old, randomly recruited age- and sex-stratified individuals from the general population. A correlation analysis exploring the relationships between LDLox and relevant biomarkers was undertaken, as well as the development and validation of several machine learning algorithms, for estimating the risk of the combined status of high blood pressure and obesity for the MARK-AGE subjects. The machine learning models yielded Area Under the Receiver Operating Characteristic Curve Score ranging 0.783-0.839 for the internal validation, while the external validation resulted in an Under the Receiver Operating Characteristic Curve Score between 0.648 and 0.787, with the variables based on LDLox reaching significant importance within the obtained predictions. The current study offers novel insights regarding the combined effects of LDL oxidation and other ageing markers on cardiometabolic risk. Future studies might be extended on larger patient cohorts, in order to obtain reproducible clinical assessment models.
Authors 29
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Andrei Valeanu corresponding
Carol Davila University of Medicine and Pharmacy
Affiliation as printed
Carol Davila University of Medicine and Pharmacy, Faculty of Pharmacy, 6 Traian Vuia St., Bucharest 020956, Romania. Electronic address: andrei.valeanu@umfcd.ro
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Carol Davila University of Medicine and Pharmacy
Affiliation as printed
Carol Davila University of Medicine and Pharmacy, Faculty of Pharmacy, 6 Traian Vuia St., Bucharest 020956, Romania. Electronic address: denisa.margina@umfcd.ro
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German Institute of Human Nutrition
Affiliation as printed
Department of Molecular Toxicology, German Institute of Human Nutrition, Potsdam-Rehbrücke, Nuthetal 14558, Germany; NutriAct-Competence Cluster Nutrition Research Berlin-Potsdam, Nuthetal 14458, Germany. Electronic address: Daniela.Weber@dife.de
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Affiliation as printed
Department of Food Biofunctionality, Institute of Nutritional Sciences (140), University of Hohenheim, Stuttgart 70599, Germany. Electronic address: wolfgang.stuetz@uni-hohenheim.de
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Affiliation as printed
Molecular Toxicology Group, Department of Biology, University of Konstanz, Konstanz 78457, Germany; Human Performance Research Centre, Department of Sport Science, University of Konstanz, Konstanz 78457, Germany. Electronic address: maria.moreno-villanueva@uni-konstanz.de
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National Institute for Public Health and the Environment
Affiliation as printed
Centre for Health Protection, National Institute for Public Health and the Environment, PO Box 1, Bilthoven 3720 BA, the Netherlands. Electronic address: Martijn.Dolle@rivm.nl
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National Institute for Public Health and the Environment
Affiliation as printed
Centre for Health Protection, National Institute for Public Health and the Environment, PO Box 1, Bilthoven 3720 BA, the Netherlands. Electronic address: eugenejansen99@gmail.com
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National Hellenic Research Foundation
Affiliation as printed
National Hellenic Research Foundation, Institute of Biology, Medicinal Chemistry and Biotechnology, Athens, Greece. Electronic address: sgonos@eie.gr
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Affiliation as printed
BioTeSys GmbH, Schelztorstr. 54-56, Esslingen 73728, Germany. Electronic address: j.bernhardt@biotesys.de
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Affiliation as printed
Research Institute for Biomedical Aging Research, University of Innsbruck, Rennweg, 10, Innsbruck 6020, Austria. Electronic address: Beatrix.Grubeck-Loebenstein@uibk.ac.at
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Affiliation as printed
Research Institute for Biomedical Aging Research, University of Innsbruck, Rennweg, 10, Innsbruck 6020, Austria. Electronic address: birgit.weinberger@uibk.ac.at
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UMIT TIROL - Private University for Health Sciences and Health Technology
Affiliation as printed
UMIT TIROL - Private University for Health Sciences, Medical Informatics and Technology, Hall in Tyrol 6060, Austria. Electronic address: simone.fiegl@umit-tirol.at
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Instytut Biologii Doświadczalnej im. Marcelego Nenckiego · Polish Academy of Sciences
Affiliation as printed
Laboratory of the Molecular Bases of Ageing, Nencki Institute of Experimental Biology, Polish Academy of Sciences, 3 Pasteur street, Warsaw 02-093, Poland. Electronic address: e.sikora@nencki.edu.pl
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Instytut Biologii Doświadczalnej im. Marcelego Nenckiego · Polish Academy of Sciences
Affiliation as printed
Laboratory of the Molecular Bases of Ageing, Nencki Institute of Experimental Biology, Polish Academy of Sciences, 3 Pasteur street, Warsaw 02-093, Poland. Electronic address: g.mosieniak@nencki.edu.pl
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University of Namur · Namur Research Institute for Life Sciences
Affiliation as printed
URBC-NARILIS, University of Namur, Rue de Bruxelles, 61, Namur, Belgium
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University of Namur · Namur Research Institute for Life Sciences
Affiliation as printed
URBC-NARILIS, University of Namur, Rue de Bruxelles, 61, Namur, Belgium. Electronic address: florence.chainiaux@unamur.be
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Affiliation as printed
Department of Medical and Surgical Sciences (DIMEC), Alma Mater Studiorum, University of Bologna, Bologna 40126, Italy; Alma Mater Research Institute on Global Challenges and Climate Change (Alma Climate), University of Bologna, Bologna 40126, Italy. Electronic address: miriam.capri@unibo.it
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Affiliation as printed
Department of Medical and Surgical Sciences (DIMEC), Alma Mater Studiorum, University of Bologna, Bologna 40126, Italy; IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy. Electronic address: paolo.garagnani2@unibo.it
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Affiliation as printed
Department of Medical and Surgical Sciences (DIMEC), Alma Mater Studiorum, University of Bologna, Bologna 40126, Italy. Electronic address: chiara.pirazzini5@unibo.it
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Istituto delle Scienze Neurologiche di Bologna
Affiliation as printed
IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy. Electronic address: mariagiulia.bacalini@isnb.it
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Affiliation as printed
Medical School, University of Tampere, Tampere 33014, Finland. Electronic address: antti.hervonen@gmail.com
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Leiden University · Leiden University Medical Center
Affiliation as printed
Section of Molecular Epidemiology, Leiden University Medical Centre, Leiden, the Netherlands. Electronic address: p.slagboom@lumc.nl
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Affiliation as printed
Department of Unilever Science and Technology, Beauty and Personal Care, Sharnbrook, UK. Electronic address: scoutwell.supplies@btinternet.com
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Affiliation as printed
Department of Applied Nutritional Science/Dietetics, Institute of Nutritional Medicine, University of Hohenheim, Stuttgart 70599, Germany. Electronic address: nicolle_breusing@yahoo.de
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Affiliation as printed
Department of Food Biofunctionality, Institute of Nutritional Sciences (140), University of Hohenheim, Stuttgart 70599, Germany. Electronic address: jan.frank@uni-hohenheim.de
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Affiliation as printed
Molecular Toxicology Group, Department of Biology, University of Konstanz, Konstanz 78457, Germany. Electronic address: alexander.buerkle@uni-konstanz.de
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N. I. Lobachevsky State University of Nizhny Novgorod · University of Bologna
Affiliation as printed
Department of Medical and Surgical Sciences (DIMEC), Alma Mater Studiorum, University of Bologna, Bologna 40126, Italy; Laboratory of Systems Medicine of Healthy Aging, Institute of Biology and Biomedicine and Institute of Information Technology, Mathematics and Mechanics, Department of Applied Mathematics, N. I. Lobachevsky State University, Nizhny Novgorod 603005, Russia. Electronic address: claudio.franceschi@unibo.it
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University of Vienna · University of Potsdam · German Centre for Cardiovascular Research · German Center for Diabetes Research · German Institute of Human Nutrition
Affiliation as printed
Department of Molecular Toxicology, German Institute of Human Nutrition, Potsdam-Rehbrücke, Nuthetal 14558, Germany; NutriAct-Competence Cluster Nutrition Research Berlin-Potsdam, Nuthetal 14458, Germany; German Center for Diabetes Research (DZD), München-Neuherberg 85764, Germany; German Center for Cardiovascular Research (DZHK), Partner Site Berlin, Berlin 13347, Germany; University of Potsdam, Institute of Nutritional Science, Nuthetal 14458, Germany; University of Vienna, Department of Physiological Chemistry, Faculty of Chemistry, Vienna 1090, Austria. Electronic address: scientific.director@dife.de
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Carol Davila University of Medicine and Pharmacy
Affiliation as printed
Carol Davila University of Medicine and Pharmacy, Faculty of Pharmacy, 6 Traian Vuia St., Bucharest 020956, Romania; Ana Aslan National Institute of Gerontology and Geriatrics, Bucharest, Romania. Electronic address: daniela.gradinaru@umfcd.ro
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