Self‐Assembled Hydrazide‐Based Nanochannels: Efficient Water Translocation and Salt Rejection
Angewandte Chemie International Edition, vol. 64, pp. e202415510
Abstract
Abstract Nature has ingeniously developed specialized water transporters that effectively reject ions, including protons, while transporting water across membranes. These natural water channels, known as aquaporins (AQPs), have inspired the creation of Artificial Water Channels (AWCs). However, replicating superfast water transport with synthetic molecular structures that exclude salts and protons is a challenging task. This endeavor demands the coexistence of a suitable water‐binding site and a selective filter for precise water transportation. Here, we present small‐molecule hydrazides 1 b–1 d that self‐assemble into a rosette‐type nanochannel assembly through intermolecular hydrogen bonding and π‐π stacking interactions, and selectively transport water molecules across lipid bilayer membranes. The experimental analysis demonstrates notable permeability rates for the 1 c derivative, enabling approximately 3.18×10 8 water molecules to traverse the channel per second. This permeability rate is about one order of magnitude lower than that of AQPs. Of particular significance, the 1 c ensures exclusive passage of water molecules while effectively blocking salts and protons. MD simulation studies confirmed the stability and water transport properties of the water channel assembly inside the bilayer membranes at ambient conditions.
Authors 6
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Abhishek Mondal Aachen
Leiden University · Indian Institute of Science Education and Research Pune
Affiliation as printed
Department of Chemistry Indian Institute of Science Education and Research Pune Dr. Homi Bhabha Road Pashan, Pune 411008, Maharashtra India
Present Address: Leiden Institute of Chemistry Leiden University 2333 CC Leiden The Netherlands
Department of Chemistry Indian Institute of Science Education and Research Pune Dr. Homi Bhabha Road Pashan, Pune 411008, Maharashtra India
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Indian Institute of Science Education and Research Pune · University of Warsaw
Affiliation as printed
Department of Chemistry Indian Institute of Science Education and Research Pune Dr. Homi Bhabha Road Pashan, Pune 411008, Maharashtra India
Present Address: Faculty of Chemistry Biological and Chemical Research Centre University of Warsaw Zwirkii Wigury 101 Warsaw 02-089 Poland
Department of Chemistry Indian Institute of Science Education and Research Pune Dr. Homi Bhabha Road Pashan, Pune 411008, Maharashtra India
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Tata Institute of Fundamental Research · TIFR Centre for Interdisciplinary Sciences
Affiliation as printed
Center for Interdisciplinary Sciences Tata Institute of Fundamental Research Hyderabad 500046 Telangana India
Center for Interdisciplinary Sciences Tata Institute of Fundamental Research Hyderabad 500046 Telangana India
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Indian Institute of Science Education and Research Pune
Affiliation as printed
Department of Chemistry Indian Institute of Science Education and Research Pune Dr. Homi Bhabha Road Pashan, Pune 411008, Maharashtra India
Department of Chemistry Indian Institute of Science Education and Research Pune Dr. Homi Bhabha Road Pashan, Pune 411008, Maharashtra India
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Tata Institute of Fundamental Research · TIFR Centre for Interdisciplinary Sciences
Affiliation as printed
Center for Interdisciplinary Sciences Tata Institute of Fundamental Research Hyderabad 500046 Telangana India
Center for Interdisciplinary Sciences Tata Institute of Fundamental Research Hyderabad 500046 Telangana India
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Pinaki Talukdar corresponding
Indian Institute of Science Education and Research Pune
Affiliation as printed
Department of Chemistry Indian Institute of Science Education and Research Pune Dr. Homi Bhabha Road Pashan, Pune 411008, Maharashtra India
Indian Institute of Science Education and Research Pune, Department of Chemistry, Main Building, Dr. Homi Bhabha Road, Pashan, 411008 Pune, INDIA
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