Engineering Lipid‐Based Pop‐up Conductive Interfaces with PEDOT:PSS and Light‐Responsive Azopolymer Films

Advanced Healthcare Materials, vol. 13, pp. e2303812

Abstract

Significant challenges have emerged in the development of biomimetic electronic interfaces capable of dynamic interaction with living organisms and biological systems, including neurons, muscles, and sensory organs. Yet, there remains a need for interfaces that can function on demand, facilitating communication and biorecognition with living cells in bioelectronic systems. In this study, the design and engineering of a responsive and conductive material with cell-instructive properties, allowing for the modification of its topography through light irradiation, resulting in the formation of "pop-up structures", is presented. A deformable substrate, composed of a bilayer comprising a light-responsive, azobenzene-containing polymer, pDR1m, and a conductive polymer, PEDOT:PSS, is fabricated and characterized. Moreover, the successful formation of supported lipid bilayers (SLBs) and the maintenance of integrity while deforming the pDR1m/PEDOT:PSS films represent promising advancements for future applications in responsive bioelectronics and neuroelectronic interfaces.

Authors 8

1. L. Terenzi Aachen Neuroelectronic Interfaces

   Forschungszentrum Jülich · RWTH Aachen University

   Affiliation as printed

   Institute of Biological Information Processing – Bioelectronics IBI‐3 Forschungszentrum Jülich 52428 Jülich Germany

   Neuroelectronic Interfaces RWTH Aachen 52074 Aachen Germany

   Institute of Biological Information Processing – Bioelectronics IBI‐3 Forschungszentrum Jülich 52428 Jülich Germany

2. Ziyu Gao Aachen Neuroelectronic Interfaces

   Forschungszentrum Jülich · RWTH Aachen University

   Affiliation as printed

   Institute of Biological Information Processing – Bioelectronics IBI‐3 Forschungszentrum Jülich 52428 Jülich Germany

   Neuroelectronic Interfaces RWTH Aachen 52074 Aachen Germany

   Institute of Biological Information Processing – Bioelectronics IBI‐3 Forschungszentrum Jülich 52428 Jülich Germany

3. Mehdi Ravandeh Aachen Neuroelectronic Interfaces

   Forschungszentrum Jülich · RWTH Aachen University

   Affiliation as printed

   Institute of Biological Information Processing – Bioelectronics IBI‐3 Forschungszentrum Jülich 52428 Jülich Germany

   Neuroelectronic Interfaces RWTH Aachen 52074 Aachen Germany

   Institute of Biological Information Processing – Bioelectronics IBI‐3 Forschungszentrum Jülich 52428 Jülich Germany

4. Chiara Fedele

   Tampere University · University of Tampere

   Affiliation as printed

   Faculty of Engineering and Natural Sciences Tampere University Tampere FI‐33720 Finland

   Faculty of Engineering and Natural Sciences, Tampere University, Tampere, FI-33720 Finland

5. Lasse Hyldgaard Klausen

   Aarhus University

   Affiliation as printed

   Interdisciplinary Nanoscience Center – INANO‐Fysik Aarhus University Aarhus 8000 Denmark

6. Claudia Latte Bovio

   Italian Institute of Technology · Center for Advanced Biomaterials for Healthcare · University of Naples Federico II

   Affiliation as printed

   Center for Advanced Biomaterials for Healthcare Italian Institute of Technology Naples 80125 Italy

   Dipartimento di Chimica, Materiali e Produzione Industriale University Federico II of Naples Naples 80125 Italy

   Center for Advanced Biomaterials for Healthcare, Italian Institute of Technology, Naples, 80125 Italy

   Dipartimento di Chimica, Materiali e Produzione Industriale, University Federico II of Naples, Naples, 80125 Italy

7. Arri Priimägi

   Tampere University · University of Tampere

   Affiliation as printed

   Faculty of Engineering and Natural Sciences Tampere University Tampere FI‐33720 Finland

   Faculty of Engineering and Natural Sciences, Tampere University, Tampere, FI-33720 Finland

8. Francesca Santoro corresponding Aachen Neuroelectronic Interfaces

   Forschungszentrum Jülich · Italian Institute of Technology · Center for Advanced Biomaterials for Healthcare · RWTH Aachen University

   Affiliation as printed

   Center for Advanced Biomaterials for Healthcare Italian Institute of Technology Naples 80125 Italy

   Institute of Biological Information Processing – Bioelectronics IBI‐3 Forschungszentrum Jülich 52428 Jülich Germany

   Neuroelectronic Interfaces RWTH Aachen 52074 Aachen Germany

   Institute of Biological Information Processing – Bioelectronics IBI‐3 Forschungszentrum Jülich 52428 Jülich Germany

   Neuroelectronic Interfaces, RWTH Aachen, 52074 Aachen, Germany