Physical performance before and after hematopoietic stem cell transplantation in pediatric patients: a potential role for prehabilitation
Bone Marrow Transplantation, vol. 59, pp. 1499–1505
Abstract
The trajectory of hematopoietic stem cell transplantation (HSCT) is often accompanied by physically disabling complications that impair physical performance of pediatric patients. However, knowledge about when impairments in physical performance arise and the factors contributing to these impairments is limited. Therefore, we conducted a retrospective analysis of physical performance 100 days post-HSCT in patients aged 3-18 years. Additionally, we aim to elucidate the relationship between pre- and post-HSCT physical performance and to unravel the impact of intensive HSCT procedures on post-HSCT physical performance. To explore associations between physical performance outcomes post-HSCT and covariates, linear regression models were estimated. Seventy-seven patients were included with a median age of 11.8 years (interquartile range: 5.9, 14.8). Patients had lower hip flexion muscle strength and appendicular skeletal muscle mass and a slower rising from the floor time 100 days post-HSCT compared to average values of the normal population. Pre-HSCT physical performance was positively associated with physical performance post-HSCT, independent of age, the cumulative glucocorticoids dosage administered and the total duration of hospitalization during the HSCT trajectory. This explorative study highlights the potential role of prehabilitation in enhancing physical performance of pediatric HSCT patients.
Authors 5
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Affiliation as printed
Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands
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University Medical Center Utrecht · Princess Máxima Center · Wilhelmina Children's Hospital
Affiliation as printed
Department of Pediatrics, Wilhelmina Children's Hospital University Medical Center Utrecht, Utrecht, the Netherlands
Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands
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Marta F. Fiocco Aachen Department of Biomedical Data Science Section Medical Statistics Mathematical Institute
Leiden University · Leiden University Medical Center · Princess Máxima Center
Affiliation as printed
Department of Biomedical Data Science, Section Medical Statistics, Leiden University Medical Center, Leiden, the Netherlands
Mathematical Institute, Leiden University, Leiden, the Netherlands
Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands
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University Medical Center Groningen · University of Groningen · Beatrix Kinderziekenhuis · Princess Máxima Center
Affiliation as printed
Department of Pediatric Oncology and Hematology, University of Groningen, Beatrix Children's Hospital, University Medical Center Groningen, Groningen, the Netherlands
Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands
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Emma J. Verwaaijen corresponding
Affiliation as printed
Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands. e.j.verwaaijen-3@prinsesmaximacentrum.nl
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