Sex-Specific Differences in Kidney Function and Blood Pressure Regulation
International Journal of Molecular Sciences, vol. 25, pp. 8637
Abstract
Premenopausal women generally exhibit lower blood pressure and a lower prevalence of hypertension than men of the same age, but these differences reverse postmenopause due to estrogen withdrawal. Sexual dimorphism has been described in different components of kidney physiology and pathophysiology, including the renin-angiotensin-aldosterone system, endothelin system, and tubular transporters. This review explores the sex-specific differences in kidney function and blood pressure regulation. Understanding these differences provides insights into potential therapeutic targets for managing hypertension and kidney diseases, considering the patient's sex and hormonal status.
Authors 6
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University Hospital of Ioannina · RWTH Aachen University
Affiliation as printed
Department of Nephrology, University Hospital of Ioannina, 45500 Ioannina, Greece
Division of Nephrology and Clinical Immunology, RWTH Aachen University, 52074 Aachen, Germany
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Affiliation as printed
Division of Nephrology and Clinical Immunology, RWTH Aachen University, 52074 Aachen, Germany
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Affiliation as printed
Division of Nephrology and Clinical Immunology, RWTH Aachen University, 52074 Aachen, Germany
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Aristotle University of Thessaloniki · AHEPA University Hospital
Affiliation as printed
2nd Department of Nephrology, AHEPA University Hospital Medical School, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece
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Aristotle University of Thessaloniki · AHEPA University Hospital
Affiliation as printed
2nd Department of Nephrology, AHEPA University Hospital Medical School, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece
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University Hospital of Ioannina
Affiliation as printed
Department of Nephrology, University Hospital of Ioannina, 45500 Ioannina, Greece
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