Oxygen-generating biomaterials for cardiovascular engineering: unveiling future discoveries

Drug Discovery Today, vol. 29, pp. 104135

Abstract

Oxygen-generating biomaterials are emerging as a groundbreaking solution for transforming cardiovascular engineering. These biomaterials generate and release oxygen within various biomedical applications, marking a new frontier in healthcare. Most cardiovascular treatments face a significant challenge, ensuring a consistent oxygen supply to nurture engineered tissues or even implanted devices. Traditional methods relying on passive oxygen diffusion often fall short, hindering functional cardiovascular tissue development. Oxygen-generating biomaterials, incorporating agents like calcium peroxide, provide a controlled oxygen source to the surrounding cells. This innovation potentially enhances cell viability, stimulates growth and boosts metabolic activity crucial for tissue health. Applications include repairing cardiac and vascular tissues, disease modeling, drug testing and personalized medicine, promising tailored treatments. Challenges like material toxicity and oxygen release control need consideration. As research progresses, the use of these innovative biomaterials in clinical translation could reshape cardiovascular healthcare, revolutionizing patient outcomes in heart disease treatment.

Authors 2

1. Masoud Mozafari corresponding

   University of Oulu

   Affiliation as printed

   Research Unit of Health Sciences and Technology, Faculty of Medicine, University of Oulu, Oulu, Finland. Electronic address: mozafari.masoud@gmail.com

   Research Unit of Health Sciences and Technology, Faculty of Medicine, University of Oulu, Oulu, Finland

2. Mohammad Esmaeil Barbati Aachen Clinic of Vascular and Endovascular Surgery

   RWTH Aachen University · Universitätsklinikum Aachen

   Affiliation as printed

   Clinic of Vascular and Endovascular Surgery, RWTH Aachen University Hospital, Aachen, Germany