Advancing Hematopoietic Stem Cell Transplantation Typing: Harnessing Hyperledger Fabric’s Blockchain Architecture
IEEE Access, vol. 12, pp. 117884–117898
Abstract
Hematopoietic stem cell transplantation (HSCT) is a crucial treatment option for hematological disorders. This study aims to design and develop a blockchain-based system tailored explicitly for HSCT typing and evaluate its performance and capabilities. The system, built on Hyperledger Fabric 2.4.6 and integrated with LevelDB and MySQL databases, implements features such as data on-chaining, access control, information retrieval, and matching through chaincode. It ensures accurate and efficient human leukocyte antigen (HLA) typing while protecting patient and hospital data security. Tests demonstrate the system’s ability to safeguard data security and reliability effectively. Performance metrics, including block size, CPU utilization, network throughput, and response latency, were evaluated on Ubuntu 20.04.2 operating systems using VMware Workstation 16 Pro and Docker containerization. By leveraging blockchain’s traceability and immutability, the system achieves data security, reliability, and verifiability, enabling faster and more accurate typing and improved healthcare efficiency. This innovative approach optimizes user experience, maintains data integrity, and ensures privacy. Future integration with existing databases could enable secure data sharing among healthcare institutions, allowing rapid verification of data ownership and unified authentication. This study contributes a significant advancement in hematologic disease treatment and research, offering practical implications for improving HSCT processes.
Authors 6
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Sanda University · SEGi University
Affiliation as printed
School of Information Science and Technology, Sanda University, Shanghai, China
Faculty of Education, Languages, Psychology and Music, SEGi University, Selangor, Malaysia
Innovative Research Center of AI in Finance, Sanda University, Shanghai, China
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Affiliation as printed
Faculty of Education, Languages, Psychology and Music, SEGi University, Petaling Jaya, Selangor, Malaysia
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Affiliation as printed
Faculty of Education, Languages, Psychology and Music, SEGi University, Petaling Jaya, Selangor, Malaysia
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Leiden University · Sanda University
Affiliation as printed
Innovative Research Center of AI in Finance, Sanda University, Shanghai, China
Computer Science and Artificial Intelligence Department, Leiden University, Leiden, Netherlands
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Soochow University · First Affiliated Hospital of Soochow University
Affiliation as printed
Department of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, China
Collaborative Innovation Center of Hematology, Institute of Blood and Marrow Transplantation, Soochow University, Suzhou, China
Institute of Hematology, National Clinical Research Center for Hematologic Diseases, Suzhou, China
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Soochow University · First Affiliated Hospital of Soochow University
Affiliation as printed
Department of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, China
Collaborative Innovation Center of Hematology, Institute of Blood and Marrow Transplantation, Soochow University, Suzhou, China
Institute of Hematology, National Clinical Research Center for Hematologic Diseases, Suzhou, China
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