Changes in blood biomarkers correlate with changes in cardiac size and function in patients with tetralogy of Fallot
International Journal of Cardiology Congenital Heart Disease, vol. 17, pp. 100522
Abstract
Patients after surgical correction of Tetralogy of Fallot (ToF) often show adverse cardiac remodelling. To better understand the underlying biological processes, we studied the relation between changes in blood biomarkers and changes in biventricular size and function as assessed by cardiac magnetic resonance imaging (CMR). This study included 50 ToF patients, who underwent blood biomarker and CMR analysis at least twice between 2002 and 2018. 34 (68%) of these patients were male. Patients had an average age of 16.1 at first visit. Biomarkers were chosen based on earlier research by our group and included: NT-proBNP, ST2, GDF-15, DLK-1, IGFBP-1/7, and FABP-4. Pearson correlations coefficients (rpearson) were determined to quantify the relationship between changes in biomarkers and CMR measurements. For changes in parameters of right ventricular (RV) size significant correlations were observed with changes in NT-proBNP, ST-2, GDF-15, IGFBP7 and FABP-4 (rpearson between 0.28 and 0.51) . Correlations with NT-proBNP were driven by changes in RV size induced by pulmonary valve replacement (n = 9). For LV serial size changes, significant correlations were noted with changes in NT-pro-BNP, ST-2, GDF-15 and FABP-4 (rpearson between 0.32 and 0.52). In clinically stable ToF patients changes in right and left ventricular size and function correlated with alterations in blood biomarkers of inflammation and immune response to stress.
Authors 12
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Erasmus MC · Netherlands Heart Institute
Affiliation as printed
Erasmus University Medical Center, Department of Pediatrics, Division of Pediatric Cardiology, Rotterdam, the Netherlands
Erasmus University Medical Center, Department of Radiology, Rotterdam, the Netherlands
Netherlands Heart Institute, Utrecht, the Netherlands
Erasmus University Medical Center, Department of Pediatrics, division of Pediatric Cardiology, Rotterdam, The Netherlands
Erasmus University Medical Center, Department of Radiology, Rotterdam, The Netherlands
Netherlands Heart Institute, Utrecht, The Netherlands
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Erasmus MC · Netherlands Heart Institute
Affiliation as printed
Erasmus University Medical Center, Department of Pediatrics, Division of Pediatric Cardiology, Rotterdam, the Netherlands
Erasmus University Medical Center, Department of Radiology, Rotterdam, the Netherlands
Netherlands Heart Institute, Utrecht, the Netherlands
Erasmus University Medical Center, Department of Pediatrics, division of Pediatric Cardiology, Rotterdam, The Netherlands
Erasmus University Medical Center, Department of Radiology, Rotterdam, The Netherlands
Netherlands Heart Institute, Utrecht, The Netherlands
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Affiliation as printed
Erasmus University Medical Center, Department of Pediatrics, Division of Pediatric Cardiology, Rotterdam, the Netherlands
Erasmus University Medical Center, Department of Radiology, Rotterdam, the Netherlands
Erasmus University Medical Center, Department of Pediatrics, division of Pediatric Cardiology, Rotterdam, The Netherlands
Erasmus University Medical Center, Department of Radiology, Rotterdam, The Netherlands
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Leiden University Medical Center · Erasmus MC · Netherlands Heart Institute
Affiliation as printed
Erasmus University Medical Center, Department of Pediatrics, Rotterdam, the Netherlands
Leiden University Medical Center, Department of Pediatrics, Division of Pediatric Cardiology, Leiden, the Netherlands
Netherlands Heart Institute, Utrecht, the Netherlands
Leiden University Medical Center, Department of Pediatrics, division of Pediatric Cardiology, Leiden, The Netherlands
Netherlands Heart Institute, Utrecht, The Netherlands
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Affiliation as printed
Erasmus University Medical Center, Department of Cardiology, Rotterdam, the Netherlands
Erasmus University Medical Center, Department of Cardiology, Rotterdam, The Netherlands
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Affiliation as printed
Erasmus University Medical Center, Department of Pediatrics, Division of Pediatric Cardiology, Rotterdam, the Netherlands
Erasmus University Medical Center, Department of Pediatrics, division of Pediatric Cardiology, Rotterdam, The Netherlands
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Leiden University Medical Center
Affiliation as printed
Leiden University Medical Center, Department of Pediatrics, Division of Pediatric Cardiology, Leiden, the Netherlands
Leiden University Medical Center, Department of Pediatrics, division of Pediatric Cardiology, Leiden, The Netherlands
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University Medical Center Utrecht
Affiliation as printed
University Medical Center Utrecht, Department of Pediatric Cardiology, Utrecht, the Netherlands
University Medical Center Utrecht, Department of Pediatric Cardiology, Utrecht, The Netherlands
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Leiden University Medical Center · Amsterdam UMC Location University of Amsterdam
Affiliation as printed
Academic Medical Center, Department of Pediatrics, Division of Pediatric Cardiology, Amsterdam, the Netherlands
Leiden University Medical Center, Department of Pediatrics, Division of Pediatric Cardiology, Leiden, the Netherlands
Academic Medical Center, Department of Pediatrics, division of Pediatric Cardiology, Amsterdam, The Netherlands
Leiden University Medical Center, Department of Pediatrics, division of Pediatric Cardiology, Leiden, The Netherlands
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Affiliation as printed
Erasmus University Medical Center, Department of Cardiology, Rotterdam, the Netherlands
Erasmus University Medical Center, Department of Cardiology, Rotterdam, The Netherlands
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Affiliation as printed
Erasmus University Medical Center, Department of Pediatrics, Division of Pediatric Cardiology, Rotterdam, the Netherlands
Erasmus University Medical Center, Department of Pediatrics, division of Pediatric Cardiology, Rotterdam, The Netherlands
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Willem A. Helbing corresponding
Affiliation as printed
Erasmus University Medical Center, Department of Pediatrics, Division of Pediatric Cardiology, Rotterdam, the Netherlands
Erasmus University Medical Center, Department of Radiology, Rotterdam, the Netherlands
Erasmus University Medical Center, Department of Pediatrics, division of Pediatric Cardiology, Rotterdam, The Netherlands
Erasmus University Medical Center, Department of Radiology, Rotterdam, The Netherlands
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