A possible association between intraocular pressure changes and pigment epithelial detachment in central serous chorioretinopathy

Acta Ophthalmologica, vol. 102, pp. 843–848

Abstract

Central serous chorioretinopathy (CSC) is a frequently occurring chorioretinal disease, that is commonly associated with subretinal fluid accumulation in a generally young population. Even though choroidal abnormalities have been found to be of importance, the exact pathogenesis of CSC is still being learned. The origin of pigment epithelial detachments, seen in many CSC patients, is also unclear. Based on the follow-up of a CSC patient for more than 5 years, we hypothesize that intraocular pressure and, by extension, the pressure gradient across the Bruch's membrane, may be one factor in the pathogenesis of pigment epithelial detachments in CSC, which might very well have implications for the occurrence of and possible ways to prevent subretinal fluid in CSC.

Authors 4

1. Chandrakumar Balaratnasingam corresponding

   Lions Eye Institute · The University of Western Australia · Sir Charles Gairdner Hospital

   Affiliation as printed

   Centre for Ophthalmology and Visual Science University of Western Australia Perth Western Australia Australia

   Lions Eye Institute Nedlands Western Australia Australia

   Retina Service, Department of Ophthalmology Sir Charles Gairdner Hospital Nedlands Western Australia Australia

   Centre for Ophthalmology and Visual Science, University of Western Australia, Perth, Western Australia, Australia

   Lions Eye Institute, Nedlands, Western Australia, Australia

   Retina Service, Department of Ophthalmology, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia

2. Christine A. Curcio

   University of Alabama at Birmingham · UAB Medicine

   Affiliation as printed

   Department of Ophthalmology and Visual Sciences University of Alabama at Birmingham, Heersink School of Medicine Birmingham Alabama USA

   Department of Ophthalmology and Visual Sciences, University of Alabama at Birmingham, Heersink School of Medicine, Birmingham, Alabama, USA

3. William Huxley Morgan

   Lions Eye Institute · The University of Western Australia · Royal Perth Hospital

   Affiliation as printed

   Centre for Ophthalmology and Visual Science University of Western Australia Perth Western Australia Australia

   Glaucoma Service, Department of Ophthalmology Royal Perth Hospital Perth Western Australia Australia

   Lions Eye Institute Nedlands Western Australia Australia

   Centre for Ophthalmology and Visual Science, University of Western Australia, Perth, Western Australia, Australia

   Glaucoma Service, Department of Ophthalmology, Royal Perth Hospital, Perth, Western Australia, Australia

   Lions Eye Institute, Nedlands, Western Australia, Australia

4. Elon H. C. van Dijk Aachen Department of Ophthalmology, Leiden

   Leiden University Medical Center · Sir Charles Gairdner Hospital

   Affiliation as printed

   Leiden University Medical Center Department of Ophthalmology Leiden The Netherlands

   Retina Service, Department of Ophthalmology Sir Charles Gairdner Hospital Nedlands Western Australia Australia

   Leiden University Medical Center, Department of Ophthalmology, Leiden, The Netherlands

   Retina Service, Department of Ophthalmology, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia