Time-efficient combined morphologic and quantitative joint MRI: an in situ study of standardized knee cartilage defects in human cadaveric specimens
European Radiology Experimental, vol. 8, pp. 66
Abstract
BACKGROUND: Quantitative techniques such as T2 and T1ρ mapping allow evaluating the cartilage and meniscus. We evaluated multi-interleaved X-prepared turbo-spin echo with intuitive relaxometry (MIXTURE) sequences with turbo spin-echo (TSE) contrast and additional parameter maps versus reference TSE sequences in an in situ model of human cartilage defects. METHODS: Standardized cartilage defects of 8, 5, and 3 mm in diameter were created in the lateral femora of ten human cadaveric knee specimens (81 ± 10 years old; nine males, one female). MIXTURE sequences providing proton density-weighted fat-saturated images and T2 maps or T1-weighted images and T1ρ maps as well as the corresponding two- and three-dimensional TSE reference sequences were acquired before and after defect creation (3-T scanner; knee coil). Defect delineability, bone texture, and cartilage relaxation times were quantified. Appropriate parametric or non-parametric tests were used. RESULTS: = 43 ± 4 ms; p = 0.004). CONCLUSIONS: MIXTURE permitted time-efficient simultaneous morphologic and quantitative joint assessment based on clinical image contrasts. While providing T2 or T1ρ maps in clinically feasible scan time, morphologic image features, i.e., cartilage defects and bone texture, were comparable between MIXTURE and reference sequences. RELEVANCE STATEMENT: Equally time-efficient and versatile, the MIXTURE sequence platform combines morphologic imaging using familiar contrasts, excellent image correspondence versus corresponding reference sequences and quantitative mapping information, thereby increasing the diagnostic value beyond mere morphology. KEY POINTS: • Combined morphologic and quantitative MIXTURE sequences are based on three-dimensional TSE contrasts. • MIXTURE sequences were studied in an in situ human cartilage defect model. • Morphologic image features, i.e., defect delineabilty and bone texture, were investigated. • Morphologic image features were similar between MIXTURE and reference sequences. • MIXTURE allowed time-efficient simultaneous morphologic and quantitative knee joint assessment.
Authors 11
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Teresa Lemainque corresponding Aachen Department of Diagnostic and Interventional Radiology Medical Faculty
Affiliation as printed
Department of Diagnostic and Interventional Radiology, Medical Faculty, RWTH Aachen University, Pauwelsstr. 30, Aachen, 52074, Germany. tlemainque@ukaachen.de
Department of Diagnostic and Interventional Radiology, Medical Faculty, RWTH Aachen University, Pauwelsstr. 30, Aachen, 52074, Germany
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Affiliation as printed
Department of Diagnostic and Interventional Radiology, Medical Faculty, RWTH Aachen University, Pauwelsstr. 30, Aachen, 52074, Germany
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Affiliation as printed
Philips GmbH Market DACH, Hamburg, Germany
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Affiliation as printed
Department of Diagnostic and Interventional Radiology, Medical Faculty, RWTH Aachen University, Pauwelsstr. 30, Aachen, 52074, Germany
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Affiliation as printed
Department of Diagnostic and Interventional Radiology, Medical Faculty, RWTH Aachen University, Pauwelsstr. 30, Aachen, 52074, Germany
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Affiliation as printed
Department of Diagnostic and Interventional Radiology, Medical Faculty, RWTH Aachen University, Pauwelsstr. 30, Aachen, 52074, Germany
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Philips Japan, Limited (Japan)
Affiliation as printed
Philips Japan, Tokyo, Japan
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Affiliation as printed
Institute of Molecular and Cellular Anatomy, RWTH Aachen University, Aachen, 52074, Germany
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Christiane Katharina Kuhl Aachen Department of Diagnostic and Interventional Radiology Medical Faculty
Affiliation as printed
Department of Diagnostic and Interventional Radiology, Medical Faculty, RWTH Aachen University, Pauwelsstr. 30, Aachen, 52074, Germany
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Affiliation as printed
Department of Diagnostic and Interventional Radiology, Medical Faculty, RWTH Aachen University, Pauwelsstr. 30, Aachen, 52074, Germany
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Affiliation as printed
Department of Diagnostic and Interventional Radiology, Medical Faculty, RWTH Aachen University, Pauwelsstr. 30, Aachen, 52074, Germany
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