Atherosclerosis evaluation and cardiovascular risk estimation using coronary computed tomography angiography
European Heart Journal, vol. 45, pp. 1783–1800
Abstract
Clinical risk scores based on traditional risk factors of atherosclerosis correlate imprecisely to an individual's complex pathophysiological predisposition to atherosclerosis and provide limited accuracy for predicting major adverse cardiovascular events (MACE). Over the past two decades, computed tomography scanners and techniques for coronary computed tomography angiography (CCTA) analysis have substantially improved, enabling more precise atherosclerotic plaque quantification and characterization. The accuracy of CCTA for quantifying stenosis and atherosclerosis has been validated in numerous multicentre studies and has shown consistent incremental prognostic value for MACE over the clinical risk spectrum in different populations. Serial CCTA studies have advanced our understanding of vascular biology and atherosclerotic disease progression. The direct disease visualization of CCTA has the potential to be used synergistically with indirect markers of risk to significantly improve prevention of MACE, pending large-scale randomized evaluation.
Authors 18
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George Washington University · Amsterdam University Medical Centers · Vrije Universiteit Amsterdam · University of Amsterdam
Affiliation as printed
Department of Cardiology, Amsterdam UMC, Vrije Universiteit Amsterdam , Amsterdam , The Netherlands
Department of Vascular Medicine, Amsterdam UMC, University of Amsterdam , Amsterdam , The Netherlands
Division of Cardiology, The George Washington University School of Medicine , Washington, DC , United States
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Leiden University Medical Center
Affiliation as printed
Department of Cardiology, Leiden University Medical Center , Leiden , The Netherlands
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Radboud University Nijmegen · Radboud University Medical Center · University Medical Center Utrecht
Affiliation as printed
Department of Cardiology, Radboud University Medical Center , Nijmegen , The Netherlands
Department of Cardiology, University Medical Center Utrecht , Utrecht , The Netherlands
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Kaiser Permanente Bernard J. Tyson School of Medicine
Affiliation as printed
Department of Health Systems Science, Kaiser Permanente Bernard J. Tyson School of Medicine , Pasadena, CA , United States
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University of California San Diego
Affiliation as printed
Section of Cardiology, Department of Medicine, University of California , San Diego, CA , United States
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Affiliation as printed
Department of Primary Care and Public Health, Imperial College London , London , United Kingdom
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Affiliation as printed
Faculty of Medicine and Health, University of Sydney , Australia, St Leonards , Australia
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University of Colorado Anschutz · University of Colorado Denver
Affiliation as printed
Department of Medicine, University of Colorado School of Medicine , Aurora, CO , United States
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University of Colorado Anschutz · University of Colorado Denver
Affiliation as printed
Department of Medicine, University of Colorado School of Medicine , Aurora, CO , United States
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Stanford Medicine · Stanford University
Affiliation as printed
Department of Medicine, Stanford University School of Medicine , Stanford, CA , United States
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Stanford Medicine · Stanford University
Affiliation as printed
Department of Medicine, Stanford University School of Medicine , Stanford, CA , United States
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Stanford Medicine · Stanford University
Affiliation as printed
Department of Medicine, Stanford University School of Medicine , Stanford, CA , United States
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Affiliation as printed
Cleerly, Inc. , Denver, CO , United States
Department of Radiology, The George Washington University School of Medicine , Washington, DC , United States
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Affiliation as printed
Cleerly, Inc. , Denver, CO , United States
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Leiden University Medical Center
Affiliation as printed
Department of Cardiology, Leiden University Medical Center , Leiden , The Netherlands
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Affiliation as printed
Cleerly, Inc. , Denver, CO , United States
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Stanford Medicine · Stanford University
Affiliation as printed
Department of Medicine, Stanford University School of Medicine , Stanford, CA , United States
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Icahn School of Medicine at Mount Sinai
Affiliation as printed
Mount Sinai Fuster Heart Hospital, Icahn School of Medicine at Mount Sinai , 1 Gustave Levy Place, Box 1030, New York, NY 10029 , United States
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