Dissecting CD8+ T cell pathology of severe SARS-CoV-2 infection by single-cell epitope mapping

Zenodo (CERN European Organization for Nuclear Research)

Abstract

We provide the R object of the scRNA-seq data of CD8+ T cells used in the study. An R markdown is provided to show the UMAP, antibody derived tag (ADT) derived data, TCR seq information, and binding of Dextramer reagents carrying SARS-CoV-2-derived epitopes.

Authors 24

1. Felix Schreibing Aachen Institute of Experimental Medicine and Systems Biology

   RWTH Aachen University · Universitätsklinikum Aachen

   Affiliation as printed

   Institute of Experimental Medicine and Systems Biology,University Hospital RWTH Aachen, Germany

2. Monica Toft Hannani Aachen Institute of Experimental Medicine and Systems Biology

   RWTH Aachen University · Heidelberg University · University Hospital Heidelberg

   Affiliation as printed

   Institute of Experimental Medicine and Systems Biology,University Hospital RWTH Aachen, Germany;Heidelberg University, Faculty of Medicine, and Heidelberg University Hospital, Institute for Computational Biomedicine, Heidelberg, Germany

3. Fabio Ticconi Aachen Joint Research Center for Computational Biomedicine Institute for Computational Genomics

   RWTH Aachen University · Universitätsklinikum Aachen

   Affiliation as printed

   Institute for Computational Genomics, University Hospital RWTH Aachen;Joint Research Center for Computational Biomedicine, University Hospital RWTH Aachen

4. Eleanor Fewings

   Heidelberg University · University Hospital Heidelberg

   Affiliation as printed

   Heidelberg University, Faculty of Medicine, and Heidelberg University Hospital, Institute for Computational Biomedicine, Heidelberg, Germany

5. James Shiniti Nagai Aachen Joint Research Center for Computational Biomedicine Institute for Computational Genomics

   RWTH Aachen University · Universitätsklinikum Aachen

   Affiliation as printed

   Institute for Computational Genomics, University Hospital RWTH Aachen;Joint Research Center for Computational Biomedicine, University Hospital RWTH Aachen

6. Matthias Begemann Aachen Medical Faculty Institute of Human Genetics

   RWTH Aachen University · Universitätsklinikum Aachen

   Affiliation as printed

   Institute of Human Genetics, Medical Faculty, RWTH Aachen University Hospital, Aachen, Germany

7. Christoph Kuppe Aachen Institute of Experimental Medicine and Systems Biology Rheumatological and Immunological Diseases (Medical Clinic II) Department of Renal and Hypertensive Disorders

   RWTH Aachen University · Universitätsklinikum Aachen

   Affiliation as printed

   Institute of Experimental Medicine and Systems Biology,University Hospital RWTH Aachen, Germany;Department of Renal and Hypertensive Disorders, Rheumatological and Immunological Diseases (Medical Clinic II), University Hospital RWTH Aachen

8. Ingo Kurth Aachen Medical Faculty Institute of Human Genetics

   RWTH Aachen University · Universitätsklinikum Aachen

   Affiliation as printed

   Institute of Human Genetics, Medical Faculty, RWTH Aachen University Hospital, Aachen, Germany

9. Jennifer Kranz Aachen Institute of Experimental Medicine and Systems Biology

   RWTH Aachen University · Universitätsklinikum Aachen · Sankt-Antonius-Hospital Eschweiler · Martin Luther University Halle-Wittenberg

   Affiliation as printed

   Institute of Experimental Medicine and Systems Biology,University Hospital RWTH Aachen, Germany;Department of Urology and Paediatric Urology, St Antonius Hospital, Eschweiler, Germany;Department of Urology and Kidney Transplantation, Martin Luther University, Halle (Saale), Germany

10. Dario Frank

    Sankt-Antonius-Hospital Eschweiler

    Affiliation as printed

    Department of Medicine, St Antonius Hospital, Eschweiler, Germany

11. Teresa M Anslinger Aachen Rheumatological and Immunological Diseases (Medical Clinic II) Department of Renal and Hypertensive Disorders

    RWTH Aachen University · Universitätsklinikum Aachen

    Affiliation as printed

    Department of Renal and Hypertensive Disorders, Rheumatological and Immunological Diseases (Medical Clinic II), University Hospital RWTH Aachen

12. Patrick Ziegler Aachen Institute for Occupational, Social and Environmental Medicine

    RWTH Aachen University · Universitätsklinikum Aachen

    Affiliation as printed

    Institute for Occupational, Social and Environmental Medicine, University Hospital RWTH Aachen

13. Jürgen Enczmann

    Düsseldorf University Hospital · Heinrich Heine University Düsseldorf

    Affiliation as printed

    Institute for Transplantation Diagnostics and Cell Therapeutics, University Hospital Düsseldorf, Düsseldorf, Germany

14. Vera Balz

    Düsseldorf University Hospital · Heinrich Heine University Düsseldorf

    Affiliation as printed

    Institute for Transplantation Diagnostics and Cell Therapeutics, University Hospital Düsseldorf, Düsseldorf, Germany

15. Frank Windhofer

    Düsseldorf University Hospital · Heinrich Heine University Düsseldorf

    Affiliation as printed

    Institute for Transplantation Diagnostics and Cell Therapeutics, University Hospital Düsseldorf, Düsseldorf, Germany

16. Paul Balfanz Aachen Department of Cardiology, Angiology and Intensive Care Medicine

    RWTH Aachen University · Universitätsklinikum Aachen

    Affiliation as printed

    Department of Cardiology, Angiology and Intensive Care Medicine, University Hospital RWTH Aachen

17. Christian Kurts

    University of Bonn

    Affiliation as printed

    Institute of Experimental Immunology, University of Bonn, Germany

18. Gernot Marx Aachen Department of Intensive and Intermediate Care

    RWTH Aachen University · Universitätsklinikum Aachen

    Affiliation as printed

    Department of Intensive and Intermediate Care, University Hospital RWTH Aachen

19. Nikolaus Marx Aachen Department of Cardiology, Angiology and Intensive Care Medicine

    RWTH Aachen University · Universitätsklinikum Aachen

    Affiliation as printed

    Department of Cardiology, Angiology and Intensive Care Medicine, University Hospital RWTH Aachen

20. Michael Dreher Aachen Department of Pneumology and Intensive Care Medicine

    RWTH Aachen University · Universitätsklinikum Aachen

    Affiliation as printed

    Department of Pneumology and Intensive Care Medicine, University Hospital RWTH Aachen

21. Rebekka K. Schneider Aachen Department of Cell Biology

    RWTH Aachen University · Erasmus MC

    Affiliation as printed

    Department of Cell Biology, RWTH Aachen University;Department of Developmental Biology, Erasmus Medical Center, Rotterdam, The Netherlands

22. Julio Sáez-Rodríguez Aachen Joint Research Center for Computational Biomedicine

    RWTH Aachen University · Universitätsklinikum Aachen · Heidelberg University · University Hospital Heidelberg

    Affiliation as printed

    Heidelberg University, Faculty of Medicine, and Heidelberg University Hospital, Institute for Computational Biomedicine, Heidelberg, Germany;Joint Research Center for Computational Biomedicine, University Hospital RWTH Aachen

23. Ivan G. Costa Aachen Joint Research Center for Computational Biomedicine Institute for Computational Genomics

    RWTH Aachen University · Universitätsklinikum Aachen

    Affiliation as printed

    Institute for Computational Genomics, University Hospital RWTH Aachen;Joint Research Center for Computational Biomedicine, University Hospital RWTH Aachen

24. Rafael Kramann Aachen Institute of Experimental Medicine and Systems Biology Rheumatological and Immunological Diseases (Medical Clinic II) Department of Renal and Hypertensive Disorders

    RWTH Aachen University · Universitätsklinikum Aachen · Erasmus MC

    Affiliation as printed

    Institute of Experimental Medicine and Systems Biology,University Hospital RWTH Aachen, Germany;Department of Renal and Hypertensive Disorders, Rheumatological and Immunological Diseases (Medical Clinic II), University Hospital RWTH Aachen;Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands