Roles of Mechanosensitive Channel Piezo1 in Wound Healing and Scar Formation

Life, vol. 14, pp. 377

Abstract

The ability to heal one's wounds is perhaps one of the most fundamental and critical of physiologic processes. This coordinated and closely regulated sequential biological process involves a variety of migratory and resident cells. The activation, modulation, balance, and control of these functions depend upon soluble mediators that activate cells and modulate their diverse functions. Recent advances have identified mechanotransduction as functionally integral in many different cell types and physiologic processes. The mechanically sensitive ion channel Pieoz1 is expressed on platelets, neutrophils, macrophages, endothelial cells, keratinocytes, and fibroblasts, all of which are principally involved in wound healing. On a cellular level, there have been great advances in our understanding of the functional role of Piezo1 mechanotransduction in cutaneous wounding. The blocking of Piezo1 has recently been shown to reduce scarring in vivo and yet, thus far, a comprehensive understanding of the roles that Piezo1 plays in in vivo wound healing remains lacking. Recognizing the ever-present and critical importance of optimal and reparative wound healing, and with the availability of new physical mechanomodulating devices, the time is ripe for gaining deeper insights into optimizing wound healing. In this review, we describe the current knowledge of Piezo1 related to wound healing.

Authors 4

1. Hans–Oliver Rennekampff corresponding
   Affiliation as printed

   Department of Plastic Surgery, Hand and Burn Surgery, Rhein Maas Klinikum, 52146 Wuerselen, Germany

2. Mayer Tenenhaus
   Affiliation as printed

   Independent Researcher, San Diego, CA 92107, USA

3. Isabelle Rennekampff Aachen Dental School

   RWTH Aachen University

   Affiliation as printed

   Dental School, RWTH Aachen, 52062 Aachen, Germany

4. Ziyad Alharbi

   Fakeeh College for Medical Sciences · Soliman Fakeeh Hospital

   Affiliation as printed

   Plastic Surgery and Burn Unit, Fakeeh College for Medical Sciences, Dr. Soliman Fakeeh Hospital, Jeddah 23323, Saudi Arabia