Fluorescence lifetime imaging for enhanced tumor contrast using exogenous dyes

Abstract

Oncologic surgery can greatly benefit from imaging techniques for the accurate identification of tumor-positive margins both intraoperatively and in resection specimens immediately following surgery. We have demonstrated clinically that fluorescence lifetime can significantly improve the accuracy for tumor vs. normal classification compared to fluorescence intensity in multiple cancer types using tumor targeted agents. Ongoing efforts by our group towards the translation of fluorescence lifetime imaging for intraoperative image guidance using exogenous agents will also be discussed.

Authors 22

1. Anand T. N. Kumar

   Harvard University · Massachusetts General Hospital

   Affiliation as printed

   Harvard Medical School (United States)

   Massachusetts General Hospital (United States)

2. Thinzar Min Lwin

   City Of Hope National Medical Center · City of Hope

   Affiliation as printed

   City of Hope (United States)

3. Murali Krishnamoorthy

   Harvard University · Massachusetts General Hospital

   Affiliation as printed

   Harvard Medical School (United States)

   Massachusetts General Hospital (United States)

4. Corey David Chan

   Newcastle University

   Affiliation as printed

   Newcastle Univ. (United Kingdom)

5. Andrey Prilutskiy

   University of Wisconsin–Madison

   Affiliation as printed

   Univ. of Wisconsin-Madison (United States)

6. MacLean P. Nasrallah

   University of Pennsylvania

   Affiliation as printed

   Univ. of Pennsylvania (United States)

7. Tom H. Dijkhuis Aachen Leiden Univ. (Netherlands)

   Leiden University

   Affiliation as printed

   Leiden Univ. (Netherlands)

8. Stefan A. Carp

   Harvard University · Massachusetts General Hospital

   Affiliation as printed

   Harvard Medical School (United States)

   Massachusetts General Hospital (United States)

9. Yin Pun Hung

   Harvard University · Massachusetts General Hospital

   Affiliation as printed

   Harvard Medical School (United States)

   Massachusetts General Hospital (United States)

10. Peter M. Sadow

    Harvard University · Massachusetts General Hospital

    Affiliation as printed

    Harvard Medical School (United States)

    Massachusetts General Hospital (United States)

11. William C. Faquin

    Harvard University · Massachusetts General Hospital

    Affiliation as printed

    Harvard Medical School (United States)

    Massachusetts General Hospital (United States)

12. Brian Vala Nahed

    Harvard University · Massachusetts General Hospital

    Affiliation as printed

    Harvard Medical School (United States)

    Massachusetts General Hospital (United States)

13. Allen L. Feng

    Massachusetts Eye and Ear Infirmary

    Affiliation as printed

    Massachusetts Eye and Ear (United States)

14. Kevin S. Emerick

    Massachusetts Eye and Ear Infirmary

    Affiliation as printed

    Massachusetts Eye and Ear (United States)

15. J. Sven D. Mieog Aachen Leiden Univ. (Netherlands)

    Leiden University

    Affiliation as printed

    Leiden Univ. (Netherlands)

16. Alexander L. Vahrmeijer Aachen Leiden Univ. (Netherlands)

    Leiden University

    Affiliation as printed

    Leiden Univ. (Netherlands)

17. Karthik Rajasekaran

    University of Pennsylvania

    Affiliation as printed

    Univ. of Pennsylvania (United States)

18. John Y. K. Lee

    University of Pennsylvania

    Affiliation as printed

    Univ. of Pennsylvania (United States)

19. Kenneth Samora Rankin

    Newcastle University

    Affiliation as printed

    Newcastle Univ. (United Kingdom)

20. Santiago A. Lozano‐Calderón

    Harvard University · Massachusetts General Hospital

    Affiliation as printed

    Harvard Medical School (United States)

    Massachusetts General Hospital (United States)

21. Mark Alex Varvares

    Massachusetts Eye and Ear Infirmary

    Affiliation as printed

    Massachusetts Eye and Ear (United States)

22. Kenneth K. Tanabe

    Harvard University · Massachusetts General Hospital

    Affiliation as printed

    Harvard Medical School (United States)

    Massachusetts General Hospital (United States)