Engineering Mesoscopic 3D Tumor Models with a Self‐Organizing Vascularized Matrix (Adv. Mater. 5/2024)

Advanced Materials, vol. 36

Abstract

Bioengineering In article number 2303196, Twan Lammers, Horst Fischer, Fabian Kiessling, and co-workers establish mesoscopic 3D vascularized tumors in perfusable bioreactors to mimic the onset of metastasis in vitro. The “High Tide” cover art exemplifies how a tumor spheroid triggers bioprinted endothelium's angiogenesis, akin to the moon's effect on the sea, resulting in high tides.

Authors 16

1. Federica De Lorenzi Aachen Department of Nanomedicine and Theranostics Institute for Experimental Molecular Imaging Department of Nanomedicine and Theranostics Institute for Experimental Molecular Imaging

   Universitätsklinikum Aachen · RWTH Aachen University

   Affiliation as printed

   Department of Nanomedicine and Theranostics Institute for Experimental Molecular Imaging (ExMI) RWTH Aachen University Hospital 52074 Aachen Germany

   Mildred Scheel School of Oncology (MSSO) Center for Integrated Oncology Aachen Bonn Cologne Düsseldorf (CIO^ABCD) RWTH Aachen University Hospital 52074 Aachen Germany

   Department of Nanomedicine and Theranostics, Institute for Experimental Molecular Imaging (ExMI), RWTH Aachen University Hospital, 52074 Aachen, Germany

   Mildred Scheel School of Oncology (MSSO) Center for Integrated Oncology Aachen Bonn Cologne Düsseldorf (CIOABCD) RWTH Aachen University Hospital 52074 Aachen Germany

2. Nadja Hansen Aachen Department of Dental Materials and Biomaterials Research

   Universitätsklinikum Aachen · RWTH Aachen University

   Affiliation as printed

   Department of Dental Materials and Biomaterials Research (ZWBF) RWTH Aachen University Hospital 52074 Aachen Germany

   Department of Dental Materials and Biomaterials Research (ZWBF), RWTH Aachen University Hospital, 52074 Aachen, Germany

3. Benjamin Theek Aachen Department of Nanomedicine and Theranostics Institute for Experimental Molecular Imaging Department of Nanomedicine and Theranostics Institute for Experimental Molecular Imaging

   Universitätsklinikum Aachen · RWTH Aachen University

   Affiliation as printed

   Department of Nanomedicine and Theranostics Institute for Experimental Molecular Imaging (ExMI) RWTH Aachen University Hospital 52074 Aachen Germany

   Department of Nanomedicine and Theranostics, Institute for Experimental Molecular Imaging (ExMI), RWTH Aachen University Hospital, 52074 Aachen, Germany

4. Rasika Daware Aachen Department of Nanomedicine and Theranostics Institute for Experimental Molecular Imaging Department of Nanomedicine and Theranostics Institute for Experimental Molecular Imaging

   Universitätsklinikum Aachen · RWTH Aachen University

   Affiliation as printed

   Department of Nanomedicine and Theranostics Institute for Experimental Molecular Imaging (ExMI) RWTH Aachen University Hospital 52074 Aachen Germany

   Department of Nanomedicine and Theranostics, Institute for Experimental Molecular Imaging (ExMI), RWTH Aachen University Hospital, 52074 Aachen, Germany

5. Alessandro Motta Aachen Department of Nanomedicine and Theranostics Institute for Experimental Molecular Imaging Department of Nanomedicine and Theranostics Institute for Experimental Molecular Imaging

   Universitätsklinikum Aachen · RWTH Aachen University

   Affiliation as printed

   Department of Nanomedicine and Theranostics Institute for Experimental Molecular Imaging (ExMI) RWTH Aachen University Hospital 52074 Aachen Germany

   Department of Nanomedicine and Theranostics, Institute for Experimental Molecular Imaging (ExMI), RWTH Aachen University Hospital, 52074 Aachen, Germany

6. Saskia Breuel Aachen Department of Gynecology and Obstetrics

   Universitätsklinikum Aachen · RWTH Aachen University

   Affiliation as printed

   Department of Gynecology and Obstetrics RWTH Aachen University Hospital 52074 Aachen Germany

   Department of Gynecology and Obstetrics, RWTH Aachen University Hospital, 52074 Aachen, Germany

7. Ramin Nasehi Aachen Department of Dental Materials and Biomaterials Research

   Universitätsklinikum Aachen · RWTH Aachen University

   Affiliation as printed

   Department of Dental Materials and Biomaterials Research (ZWBF) RWTH Aachen University Hospital 52074 Aachen Germany

   Department of Dental Materials and Biomaterials Research (ZWBF), RWTH Aachen University Hospital, 52074 Aachen, Germany

8. Julian Baumeister Aachen Department of Hematology Oncology Hemostaseology and Stem Cell Transplantation

   Universitätsklinikum Aachen · RWTH Aachen University

   Affiliation as printed

   Department of Hematology Oncology Hemostaseology and Stem Cell Transplantation RWTH Aachen University Hospital 52074 Aachen Germany

   Mildred Scheel School of Oncology (MSSO) Center for Integrated Oncology Aachen Bonn Cologne Düsseldorf (CIO^ABCD) RWTH Aachen University Hospital 52074 Aachen Germany

   Mildred Scheel School of Oncology (MSSO) Center for Integrated Oncology Aachen Bonn Cologne Düsseldorf (CIOABCD) RWTH Aachen University Hospital 52074 Aachen Germany

9. Jan Schöneberg Aachen Department of Dental Materials and Biomaterials Research

   Universitätsklinikum Aachen · RWTH Aachen University

   Affiliation as printed

   Department of Dental Materials and Biomaterials Research (ZWBF) RWTH Aachen University Hospital 52074 Aachen Germany

   Department of Dental Materials and Biomaterials Research (ZWBF), RWTH Aachen University Hospital, 52074 Aachen, Germany

10. Saskia Freifrau von Stillfried Aachen Institute of Pathology

    Universitätsklinikum Aachen · RWTH Aachen University

    Affiliation as printed

    Institute of Pathology RWTH Aachen University Hospital 52074 Aachen Germany

    Institute of Pathology, RWTH Aachen University Hospital, 52074 Aachen, Germany

11. Gerhard Müller‐Newen Aachen Institute of Biochemistry and Molecular Biology

    Universitätsklinikum Aachen · RWTH Aachen University

    Affiliation as printed

    Institute of Biochemistry and Molecular Biology RWTH Aachen University Hospital 52074 Aachen Germany

    Institute of Biochemistry and Molecular Biology, RWTH Aachen University Hospital, 52074 Aachen, Germany

12. Jochen Maurer Aachen Department of Gynecology and Obstetrics

    Universitätsklinikum Aachen · RWTH Aachen University

    Affiliation as printed

    Department of Gynecology and Obstetrics RWTH Aachen University Hospital 52074 Aachen Germany

    Department of Gynecology and Obstetrics, RWTH Aachen University Hospital, 52074 Aachen, Germany

13. Alexandros Marios Sofias Aachen Department of Nanomedicine and Theranostics Institute for Experimental Molecular Imaging Department of Nanomedicine and Theranostics Institute for Experimental Molecular Imaging

    Norwegian University of Science and Technology · Universitätsklinikum Aachen · RWTH Aachen University

    Affiliation as printed

    Department of Nanomedicine and Theranostics Institute for Experimental Molecular Imaging (ExMI) RWTH Aachen University Hospital 52074 Aachen Germany

    Mildred Scheel School of Oncology (MSSO) Center for Integrated Oncology Aachen Bonn Cologne Düsseldorf (CIO^ABCD) RWTH Aachen University Hospital 52074 Aachen Germany

    Norwegian University of Science and Technology (NTNU) Department of Circulation and Medical Imaging Faculty of Medicine and Health Sciences Trondheim 7491 Norway

    Department of Nanomedicine and Theranostics, Institute for Experimental Molecular Imaging (ExMI), RWTH Aachen University Hospital, 52074 Aachen, Germany

    Mildred Scheel School of Oncology (MSSO) Center for Integrated Oncology Aachen Bonn Cologne Düsseldorf (CIOABCD) RWTH Aachen University Hospital 52074 Aachen Germany

14. Twan Lammers Aachen Department of Nanomedicine and Theranostics Institute for Experimental Molecular Imaging Department of Nanomedicine and Theranostics Institute for Experimental Molecular Imaging

    Universitätsklinikum Aachen · RWTH Aachen University

    Affiliation as printed

    Department of Nanomedicine and Theranostics Institute for Experimental Molecular Imaging (ExMI) RWTH Aachen University Hospital 52074 Aachen Germany

    Mildred Scheel School of Oncology (MSSO) Center for Integrated Oncology Aachen Bonn Cologne Düsseldorf (CIO^ABCD) RWTH Aachen University Hospital 52074 Aachen Germany

    Department of Nanomedicine and Theranostics, Institute for Experimental Molecular Imaging (ExMI), RWTH Aachen University Hospital, 52074 Aachen, Germany

    Mildred Scheel School of Oncology (MSSO) Center for Integrated Oncology Aachen Bonn Cologne Düsseldorf (CIOABCD) RWTH Aachen University Hospital 52074 Aachen Germany

15. Horst Fischer Aachen Department of Dental Materials and Biomaterials Research

    Universitätsklinikum Aachen · RWTH Aachen University

    Affiliation as printed

    Department of Dental Materials and Biomaterials Research (ZWBF) RWTH Aachen University Hospital 52074 Aachen Germany

    Department of Dental Materials and Biomaterials Research (ZWBF), RWTH Aachen University Hospital, 52074 Aachen, Germany

16. Fabian M. Kiessling Aachen Institute for Experimental Molecular Imaging

    Universitätsklinikum Aachen · Fraunhofer Institute for Digital Medicine · RWTH Aachen University

    Affiliation as printed

    Fraunhofer Institute for Digital Medicine MEVIS 28359 Bremen Germany

    Institute for Experimental Molecular Imaging (ExMI) RWTH Aachen University Hospital 52074 Aachen Germany

    Fraunhofer Institute for Digital Medicine MEVIS, 28359 Bremen, Germany

    Institute for Experimental Molecular Imaging (ExMI), RWTH Aachen University Hospital, 52074 Aachen, Germany