Colorectal Cancer

Abstract

Colorectal cancer is the third most common cancer in terms of incidence and its clinical presentation, although evocative, may be indolent, therefore highlighting the necessity for population-based screening. Survival outcome of colorectal cancer is closely associated with cancer stage at initial diagnosis. Although challenged recently by alternative treatments for rectal cancer, surgical resection remains the primary treatment for colorectal cancer, and can be performed using different surgical approaches. Recent years have seen the development of robotic surgery and of transanal surgery for low rectal cancer, and of complete mesocolic excision for right-sided colon cancer, which bring more options to the surgeon's armamentarium. Moreover, neo-adjuvant treatment for rectal cancer may downstage the tumor or even allows complete clinical response with, in selected cases, possibility of entering a watch-and-wait program. On this aspect, immmunotherapy has definitely a role to play in patients with deficient mismatch repair system. Depending on the definitive pathological stage, different types of adjuvant therapies may bring some additional benefit in terms of survival.

Authors 10

1. Edited by Justin Davies

   Cambridge University Hospitals NHS Foundation Trust · Addenbrooke's Hospital

   Affiliation as printed

   Cambridge Colorectal Unit, Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK

2. Jérémy Meyer

   Cambridge University Hospitals NHS Foundation Trust · Addenbrooke's Hospital

   Affiliation as printed

   Cambridge Colorectal Unit, Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK

3. Kirill Basiliya Aachen Consultant Gastroenterologist Leiden Medical Center

   Leiden University Medical Center

   Affiliation as printed

   Consultant Gastroenterologist, Leiden Medical Centre, Belgium

4. Gareth Corbett

   Cambridge University Hospitals NHS Foundation Trust · Addenbrooke's Hospital

   Affiliation as printed

   Department of Gastroenterology, Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK

5. David J. Bowden

   Cambridge University Hospitals NHS Foundation Trust · Addenbrooke's Hospital

   Affiliation as printed

   Department of Radiology, Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK

6. Dedrick Kok Hong Chan

   National University of Singapore · National University Hospital · National University Health System

   Affiliation as printed

   Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore

   Division of Colorectal Surgery, University Surgical Cluster, National University Hospital, Singapore

7. Sean Michael O'Cathail

   University of Glasgow

   Affiliation as printed

   Senior Research Fellow, School of Cancer Sciences, University of Glasgow, Glasgow, UK

8. Magdalena Krakowska

   Copernicus Memorial Hospital · Medical University of Lodz

   Affiliation as printed

   Department of Chemotherapy, Medical University of Lodz, Copernicus Memorial Hospital, Lodz, Poland

9. Faiz Jabbar

   University of Oxford

   Affiliation as printed

   Department of Immunology, Oxford University, Hospital NHS Foundation Trust, Oxford, UK

10. David N. Church

    Centre for Human Genetics · University of Oxford

    Affiliation as printed

    Cancer Research UK Advanced Clinician Scientist Fellow, Honorary Consultant Medical Oncologist, Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK