Exploring the mixture assessment or allocation factor (MAF): A brief overview of the current discourse

Current Opinion in Toxicology, vol. 37, pp. 100460

Abstract

The European Chemicals Strategy for Sustainability requests to include a mixture assessment factor (MAF) into the safety assessment of chemicals, in order to account for the elevated risks of chemical mixtures. This text first reflects on the conceptual background of the MAF, and then provides an overview of current stakeholder positions and of the studies attempting to quantify an appropriate size of the MAF. Stakeholders from industry, civil society organizations (NGOs), and regulatory authorities have already put forth statements regarding the perceived advantages and disadvantages of the MAF approach, sometimes without providing detailed arguments. A consensus seems to emerge that the so-called MAF factor is not a suitable instrument, due to its indiscriminatory nature that penalizes even chemicals that contribute only marginally to the mixture risk. Members of the larger MAF ceiling family, in particular the MAF exact, overcome this limitation and are therefore suggested as the way forward.

Authors 1

1. Thomas Backhaus corresponding Aachen Institute for Environmental Research

   RWTH Aachen University · University of Gothenburg

   Affiliation as printed

   Department of Biological and Environmental Sciences, University of Gothenburg, Medicinaregatan 7B, 41390 Gothenburg, Sweden

   Institute for Environmental Research, RWTH University, Worringerweg 1, 52074 Aachen, Germany