Injection of IK1 through dynamic clamp can make all the difference in patch-clamp studies on hiPSC-derived cardiomyocytes

• PITX2 dosage-dependent changes in pacemaker cell state underlie sinus node dysfunction and atrial arrhythmias

  2025 Nature Communications article Medicine Cardiac electrophysiology and arrhythmias Open access

  4

  citations
• Adeno-associated virus (AAV)-TBX18 does not generate biological pacemaker activity, unlike AAV-Hcn2

  2025 bioRxiv (Cold Spring Harbor Laboratory) preprint Medicine Cardiac electrophysiology and arrhythmias Open access

  0

  citations
• The Brugada syndrome associated gene WT1 impacts on SCN5A expression and cardiac conduction

  2025 bioRxiv (Cold Spring Harbor Laboratory) preprint Medicine Cardiac electrophysiology and arrhythmias Open access

  0

  citations
• Chronic Mexiletine Administration Increases Sodium Current in Non-Diseased Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes

  2024 Biomedicines article Medicine Cardiac electrophysiology and arrhythmias Open access

  6

  citations

4 results

• Human-iPSC-Derived Cardiac Stromal Cells Enhance Maturation in 3D Cardiac Microtissues and Reveal Non-cardiomyocyte Contributions to Heart Disease

  2020 Cell stem cell article Biochemistry, Genetics and Molecular Biology Pluripotent Stem Cells Research Open access cited by 13 patents

  643

  citations
• Cryopreservation of human pluripotent stem cell-derived cardiomyocytes is not detrimental to their molecular and functional properties

  2020 Stem Cell Research article Biochemistry, Genetics and Molecular Biology Pluripotent Stem Cells Research Open access cited by 1 patent

  50

  citations
• Isogenic Sets of hiPSC-CMs Harboring Distinct KCNH2 Mutations Differ Functionally and in Susceptibility to Drug-Induced Arrhythmias

  2020 Stem Cell Reports article Medicine Cardiac electrophysiology and arrhythmias Open access cited by 1 patent

  44

  citations
• Maturation of hiPSC-derived cardiomyocytes promotes adult alternative splicing of SCN5A and reveals changes in sodium current associated with cardiac arrhythmia

  2022 Cardiovascular Research article Medicine Cardiac electrophysiology and arrhythmias Open access

  43

  citations
• Self-restoration of cardiac excitation rhythm by anti-arrhythmic ion channel gating

  2020 eLife article Medicine Cardiac electrophysiology and arrhythmias Open access

  20

  citations
• Beneficial effects of chronic mexiletine treatment in a human model of SCN5A overlap syndrome

  2023 EP Europace article Medicine Cardiac electrophysiology and arrhythmias Open access

  17

  citations
• The Linkage Phase of the Polymorphism KCNH2-K897T Influences the Electrophysiological Phenotype in hiPSC Models of LQT2

  2021 Frontiers in Physiology article Medicine Cardiac electrophysiology and arrhythmias Open access

  5

  citations

7 results