A Low or High Physical Activity Level Does Not Modulate Prostate Tumor Tissue Protein Synthesis Rates
Medicine & Science in Sports & Exercise, vol. 56, pp. 635–643
Abstract
INTRODUCTION: Physical activity level has been identified as an important factor in the development and progression of various types of cancer. In this study, we determined the impact of a low versus high physical activity level on skeletal muscle, healthy prostate, and prostate tumor protein synthesis rates in vivo in prostate cancer patients. METHODS: Thirty prostate cancer patients (age, 66 ± 5 yr; body mass index, 27.4 ± 2.9 kg·m -2 ) were randomized to a low (<4000 steps per day, n = 15) or high (>14,000 steps per day, n = 15) physical activity level for 7 d before their scheduled radical prostatectomy. Daily deuterium oxide administration was combined with the collection of plasma, skeletal muscle, nontumorous prostate, and prostate tumor tissue during the surgical procedure to determine tissue protein synthesis rates throughout the intervention period. RESULTS: Daily step counts averaged 3610 ± 878 and 17,589 ± 4680 steps in patients subjected to the low and high physical activity levels, respectively ( P < 0.001). No differences were observed between tissue protein synthesis rates of skeletal muscle, healthy prostate, or prostate tumor between the low (1.47% ± 0.21%, 2.74% ± 0.70%, and 4.76% ± 1.23% per day, respectively) and high (1.42% ± 0.16%, 2.64% ± 0.58%, and 4.72% ± 0.80% per day, respectively) physical activity group (all P > 0.4). Tissue protein synthesis rates were nearly twofold higher in prostate tumor compared with nontumorous prostate tissue. CONCLUSIONS: A short-term high or low physical activity level does not modulate prostate or prostate tumor protein synthesis rates in vivo in prostate cancer patients. More studies on the impact of physical activity level on tumor protein synthesis rates and tumor progression are warranted to understand the potential impact of lifestyle interventions in the prevention and treatment of cancer.
Authors 11
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Maastricht University Medical Centre · Maastricht University · TiFN · Netherlands Comprehensive Cancer Organisation
Affiliation as printed
Department of Human Biology, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre +, Maastricht, THE NETHERLANDS
Department of Research & Development, Netherlands Comprehensive Cancer Organisation (IKNL), Utrecht, THE NETHERLANDS
TiFN, Wageningen, The Netherlands
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Affiliation as printed
Department of Urology, Jessa Hospital, Hasselt, BELGIUM
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Maastricht University Medical Centre · Maastricht University
Affiliation as printed
Department of Human Biology, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre+, Maastricht, THE NETHERLANDS
Department of Human Biology, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre +, Maastricht, THE NETHERLANDS
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Affiliation as printed
Department of Pathology, Jessa Hospital, Hasselt, BELGIUM
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Maastricht University Medical Centre · Maastricht University
Affiliation as printed
Department of Human Biology, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre+, Maastricht, THE NETHERLANDS
Department of Human Biology, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre +, Maastricht, THE NETHERLANDS
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Maastricht University Medical Centre
Affiliation as printed
Central Diagnostic Laboratory, Maastricht University Medical Centre+, Maastricht, THE NETHERLANDS
Central Diagnostic Laboratory, Maastricht University Medical Centre +, Maastricht, THE NETHERLANDS
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Maastricht University Medical Centre · Maastricht University · RWTH Aachen University
Affiliation as printed
Department of Surgery, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre +, Maastricht, THE NETHERLANDS
Department of Visceral and Transplantation surgery, RWTH Aachen University, Aachen, GERMANY
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Maastricht University Medical Centre · Maastricht University · TiFN
Affiliation as printed
Department of Human Biology, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre +, Maastricht, THE NETHERLANDS
TiFN, Wageningen, The Netherlands
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Maastricht University Medical Centre · TiFN · Netherlands Comprehensive Cancer Organisation
Affiliation as printed
Department of Dietetics, Maastricht University Medical Centre +, Maastricht, THE NETHERLANDS
Department of Research & Development, Netherlands Comprehensive Cancer Organisation (IKNL), Utrecht, THE NETHERLANDS
TiFN, Wageningen, The Netherlands
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Universitair Ziekenhuis Leuven · Jessa Hospital · Hasselt University
Affiliation as printed
Department of Urology, Jessa Hospital, Hasselt, BELGIUM
Department of Urology, University Hospital Leuven, Leuven, BELGIUM
Faculty of Medicine, Hasselt University, Hasselt, Belgium
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Luc J. C. van Loon corresponding
Maastricht University Medical Centre · Maastricht University · TiFN
Affiliation as printed
Department of Human Biology, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre +, Maastricht, THE NETHERLANDS
Prof. Dr. Luc J. C. van Loon, Department of Human Biology, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre +, P.O. Box 616, 6200 MD Maastricht, The Netherlands; Tel: +(31) 43 3881397; E-mail: [email protected]
TiFN, Wageningen, The Netherlands
E-mail: [email protected]
Prof. Dr. Luc J. C. van Loon, Department of Human Biology, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre +, P.O. Box 616, 6200 MD Maastricht, The Netherlands
Tel: +(31) 43 3881397
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