Structural Elucidation Based on Photo-CIDNP NMR

Royal Society of Chemistry eBooks, pp. 301–326

Abstract

The lack of signal often limits NMR analysis. Since the signal-to-noise ratio increases with the square root of time, extending the measurement time is not always applicable. An alternative approach is the transient induction of non-Boltzmann spin distribution. This strategy, also called “hyperpolarization”, leads to a dramatic enhancement of the NMR signals. Several different methods are presently explored and applied. Here we present the opportunities for structural biology opened by (photo-)chemically induced dynamic nuclear polarization (photo-CIDNP), i.e., nuclear hyperpolarization occurring in (photo-)chemical reactions involving radical pairs.

Authors 6

1. Jörg Matysik

   Leipzig University

   Affiliation as printed

   aInstitut für Analytische Chemie, Universität Leipzig, Linnéstr. 3, 04103 Leipzig, Germany

2. Yunmi Kim

   Leipzig University

   Affiliation as printed

   aInstitut für Analytische Chemie, Universität Leipzig, Linnéstr. 3, 04103 Leipzig, Germany

3. Patrick Kurle-Tucholski

   Leipzig University

   Affiliation as printed

   aInstitut für Analytische Chemie, Universität Leipzig, Linnéstr. 3, 04103 Leipzig, Germany

4. Guzel Musabirova

   Leipzig University

   Affiliation as printed

   aInstitut für Analytische Chemie, Universität Leipzig, Linnéstr. 3, 04103 Leipzig, Germany

5. Ruonan Qin

   Leipzig University

   Affiliation as printed

   aInstitut für Analytische Chemie, Universität Leipzig, Linnéstr. 3, 04103 Leipzig, Germany

6. A. Alia Aachen

   Leiden University · Leipzig University

   Affiliation as printed

   bInstitut für Medizinische Physik und Biophysik, Universität Leipzig, Härtelstr. 16-18, 04107 Leipzig, Germany

   cLeiden Institute of Chemistry, Leiden University, 2333 CC Leiden, Einsteinweg 55, The Netherlands