Developing an artificial intelligence–based decision engine for disease-modifying therapy in heart failure: a pilot study
European Heart Journal - Digital Health, vol. 6, pp. 285–288
Abstract
Aims: Heart failure is an escalating burden on global healthcare systems. Modernizing heart failure care is inevitable, with eHealth products poised to play an important role. However, eHealth devices that can initiate and adjust heart failure medication are currently lacking. Consequently, this study aimed to develop an artificial intelligence-based decision engine to provide guideline-based recommendations for disease-modifying medication in heart failure patients. Methods and results: We developed the decision engine by converting the European Society of Cardiology (ESC) heart failure guidelines into Business Process Model and Notation, a visual modelling language suitable for developing complex decision engines. A safety evaluation, based on clinical parameters, was conducted to ascertain the system's applicability to specific cases. The decision engine renders specific decisions concerning disease- modifying therapy for heart failure patients. We defined 72 virtual heart failure patient scenarios, encompassing a broad spectrum of baseline characteristics and background medication. All recommendations offered by the engine were evaluated by an independent heart failure specialist. All but three recommendations (94%) were identical to the treatment decisions by the heart failure specialist, and all (100%) were in line with the 2021 ESC heart failure guidelines. Conclusion: The decision engine offers guideline-based recommendations for disease-modifying therapy, positioning it as a tool to enhance self-care among heart failure patients. To validate our results, the decision engine is being prospectively tested in real-world patients in a multicentre clinical trial (NCT04699253).
Authors 12
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Maastricht University Medical Centre
Affiliation as printed
Department of Cardiology, Maastricht University Medical Centre , P.Debyelaan 25, 6229 HX Maastricht ,
Department of Cardiology, Maastricht University Medical Centre , Maastricht , The Netherlands
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Hesam Amin corresponding
Maastricht University Medical Centre · Medisch Spectrum Twente · Maastricht University
Affiliation as printed
CARIM School for Cardiovascular Diseases, Maastricht University , Universiteitssingel 50, 6200 MD Maastricht ,
Department of Cardiology, Maastricht University Medical Centre , P.Debyelaan 25, 6229 HX Maastricht ,
Department of Cardiology, Thoraxcentrum Twente, Medisch Spectrum Twente , Koningsplein 1, 7512 KZ Enschede ,
CARIM School for Cardiovascular Diseases, Maastricht University , Maastricht , The Netherlands
Department of Cardiology, Maastricht University Medical Centre , Maastricht , The Netherlands
Department of Cardiology, Thoraxcentrum Twente, Medisch Spectrum Twente , Enschede , The Netherlands
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Universitätsklinikum Aachen · RWTH Aachen University
Affiliation as printed
Department of Internal Medicine I, University Hospital Aachen, RWTH Aachen University , 52074 Aachen ,
Department of Internal Medicine I, University Hospital Aachen, RWTH Aachen University , 52074 Aachen , Germany
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Affiliation as printed
Sananet Care BV , Sittard ,
Sananet Care BV , Sittard , The Netherlands
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Affiliation as printed
Sananet Care BV , Sittard ,
Sananet Care BV , Sittard , The Netherlands
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Universitätsklinikum Aachen · RWTH Aachen University
Affiliation as printed
Department of Internal Medicine I, University Hospital Aachen, RWTH Aachen University , 52074 Aachen ,
Department of Internal Medicine I, University Hospital Aachen, RWTH Aachen University , 52074 Aachen , Germany
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Maastricht University Medical Centre · Maastricht University
Affiliation as printed
CARIM School for Cardiovascular Diseases, Maastricht University , Universiteitssingel 50, 6200 MD Maastricht ,
Department of Cardiology, Maastricht University Medical Centre , P.Debyelaan 25, 6229 HX Maastricht ,
CARIM School for Cardiovascular Diseases, Maastricht University , Maastricht , The Netherlands
Department of Cardiology, Maastricht University Medical Centre , Maastricht , The Netherlands
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St. Vincent's University Hospital
Affiliation as printed
Department of Cardiology, St Vincent’s Healthcare Group , Dublin ,
Department of Cardiology, St Vincent’s Healthcare Group , Dublin , Ireland
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Belfast Health and Social Care Trust · Belfast City Hospital
Affiliation as printed
Belfast Health and Social Care Trust, A Floor, Belfast City Hospital , Belfast ,
Belfast Health and Social Care Trust, A Floor, Belfast City Hospital , Belfast , United Kingdom
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Affiliation as printed
School of Nursing and Midwifery, Queen’s University Belfast , Belfast ,
11 School of Nursing and Midwifery, Queen's University Belfast , Belfast , United Kingdom
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Maastricht University Medical Centre · Maastricht University
Affiliation as printed
CARIM School for Cardiovascular Diseases, Maastricht University , Universiteitssingel 50, 6200 MD Maastricht ,
Department of Cardiology, Maastricht University Medical Centre , P.Debyelaan 25, 6229 HX Maastricht ,
CARIM School for Cardiovascular Diseases, Maastricht University , Maastricht , The Netherlands
Department of Cardiology, Maastricht University Medical Centre+ , Maastricht , the Netherlands
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Maastricht University Medical Centre · Maastricht University
Affiliation as printed
CARIM School for Cardiovascular Diseases, Maastricht University , Universiteitssingel 50, 6200 MD Maastricht ,
Department of Cardiology, Maastricht University Medical Centre , P.Debyelaan 25, 6229 HX Maastricht ,
CARIM School for Cardiovascular Diseases, Maastricht University , Maastricht , The Netherlands
Department of Cardiology, Maastricht University Medical Centre , Maastricht , The Netherlands
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