Trans -cyclosulfamidate mannose-configured cyclitol allows isoform-dependent inhibition of GH47 α- d -mannosidases through a bump–hole strategy

Chemical Science, vol. 14, pp. 13581–13586

Abstract

1,6- Trans -manno-cyclosulfamidate 6 inhibits selectively an L310S mutant of Caulobacter GH47 α- d -mannosidase by virtue of its 1 C 4 conformation and bump-and-hole strategy, enabling allele-specific inhibition within the GH47 α-mannosidase family.

Authors 13

1. Alexandra Males

   University of York

   Affiliation as printed

   York Structural Biology Laboratory, Department of Chemistry, The University of York, York YO10 5DD, UK

2. Ken Kok Aachen Department of Medical Biochemistry Leiden Institute of Chemistry

   Leiden University

   Affiliation as printed

   Department of Medical Biochemistry, Leiden Institute of Chemistry (LIC), Leiden University, P. O. Box 9502, 2300 RA Leiden, The Netherlands

3. Alba Nin‐Hill

   Institució Catalana de Recerca i Estudis Avançats · Universitat de Barcelona

   Affiliation as printed

   Departament de Química Inorgànica i Orgànica (Secció de Química Orgànica), Institut de Química Teòrica i Computacional (IQTCUB), Universitat de Barcelona, Martí i Franquès 1, 08028 Barcelona, Spain

   Fundació Catalana de Recerca i Estudis Avançats (ICREA), Passeig Lluís Companys 23, 08010 Barcelona, Spain

4. Nicky de Koster Aachen Department of Medical Biochemistry Leiden Institute of Chemistry

   Leiden University

   Affiliation as printed

   Department of Medical Biochemistry, Leiden Institute of Chemistry (LIC), Leiden University, P. O. Box 9502, 2300 RA Leiden, The Netherlands

5. Sija van den Beukel Aachen Department of Medical Biochemistry Leiden Institute of Chemistry

   Leiden University

   Affiliation as printed

   Department of Medical Biochemistry, Leiden Institute of Chemistry (LIC), Leiden University, P. O. Box 9502, 2300 RA Leiden, The Netherlands

6. Thomas J. M. Beenakker Aachen Department of Bio-organic Synthesis Leiden Institute of Chemistry

   Leiden University

   Affiliation as printed

   Department of Bio-organic Synthesis, Leiden Institute of Chemistry (LIC), Leiden University, Einsteinweg 55, 2333 CC Leiden, The Netherlands

7. Gijsbert A. van der Marel Aachen Department of Bio-organic Synthesis Leiden Institute of Chemistry

   Leiden University

   Affiliation as printed

   Department of Bio-organic Synthesis, Leiden Institute of Chemistry (LIC), Leiden University, Einsteinweg 55, 2333 CC Leiden, The Netherlands

8. Jeroen D. C. Codée Aachen Department of Bio-organic Synthesis Leiden Institute of Chemistry

   Leiden University

   Affiliation as printed

   Department of Bio-organic Synthesis, Leiden Institute of Chemistry (LIC), Leiden University, Einsteinweg 55, 2333 CC Leiden, The Netherlands

9. Johannes M. F. G. Aerts Aachen Department of Medical Biochemistry Leiden Institute of Chemistry

   Leiden University

   Affiliation as printed

   Department of Medical Biochemistry, Leiden Institute of Chemistry (LIC), Leiden University, P. O. Box 9502, 2300 RA Leiden, The Netherlands

10. Herman S. Overkleeft Aachen Department of Bio-organic Synthesis Leiden Institute of Chemistry

    Leiden University

    Affiliation as printed

    Department of Bio-organic Synthesis, Leiden Institute of Chemistry (LIC), Leiden University, Einsteinweg 55, 2333 CC Leiden, The Netherlands

11. Carme Rovira corresponding

    Institució Catalana de Recerca i Estudis Avançats · Universitat de Barcelona

    Affiliation as printed

    Departament de Química Inorgànica i Orgànica (Secció de Química Orgànica), Institut de Química Teòrica i Computacional (IQTCUB), Universitat de Barcelona, Martí i Franquès 1, 08028 Barcelona, Spain

    Fundació Catalana de Recerca i Estudis Avançats (ICREA), Passeig Lluís Companys 23, 08010 Barcelona, Spain

12. G.J. Davies corresponding

    University of York

    Affiliation as printed

    York Structural Biology Laboratory, Department of Chemistry, The University of York, York YO10 5DD, UK

13. Marta Artola corresponding Aachen Department of Medical Biochemistry Leiden Institute of Chemistry

    Leiden University

    Affiliation as printed

    Department of Medical Biochemistry, Leiden Institute of Chemistry (LIC), Leiden University, P. O. Box 9502, 2300 RA Leiden, The Netherlands