PB0530 Sex-Specific Differences in Procoagulant Profiles

Research and Practice in Thrombosis and Haemostasis, vol. 7, pp. 100781

Abstract

Image: Osocimab effects on transmembrane pressure, fibrinogen consumption and platelet count during hemodialysis.Image: Osocimab effects on fibrinogen consumption and platelet count during ECMO. Conclusion(s):In aggressive ex vivo models of extracorporeal circuits due to the frequent re-circulation of blood and lack of endothelial cells, inhibition of FXIa by osocimab, when combined with enoxaparin, prolonged time to circuit clotting, providing support for further in vivo testing.

Authors 5

1. Andréa Coy-Canguçu

   Pontifícia Universidade Católica de Campinas

   Affiliation as printed

   Catholic Pontifical University of Campinas, Campinas, Sao Paulo, Brazil;

2. Fernanda Andrade Orsi

   Universidade de São Paulo

   Affiliation as printed

   University of São Paulo Medical School, São Paulo, Sao Paulo, Brazil;

3. Frits Richard Rosendaal Aachen Department of Clinical Epidemiology

   Leiden University Medical Center

   Affiliation as printed

   Department of Clinical Epidemiology, Leiden University Medical Center,

4. Suzanne C. Cannegieter
5. Luuk J.J. Scheres