Validation of transparent and flexible neural implants for simultaneous electrophysiology, functional imaging, and optogenetics

Journal of Materials Chemistry B, vol. 11, pp. 9639–9657

Abstract

a combination of solid gold interconnects and PEDOT:PSS-based electrodes (pp-μECoGs). Both implants allowed simultaneous multimodal recordings but pp-μECoGs offered the best overall electrical, electrochemical, and optical properties with negligible photo-induced artefacts to light wavelengths of interest. Showing functional chronic stability for up to four months, pp-μECoGs also allowed the simultaneous functional mapping of electrical and calcium neural signals upon visual and tactile stimuli during widefield imaging. Moreover, recordings during two-photon imaging showed no visible signal attenuation and enabled the correlation of network dynamics across brain regions to individual neurons located directly below the transparent electrical contacts.

Authors 9

1. Lina Koschinski Aachen

   Forschungszentrum Jülich · RWTH Aachen University

   Affiliation as printed

   Helmholtz Nano Facility (HNF), Forschungszentrum, Jülich, Germany

   Institute of Biological Information Processing (IBI-3) – Bioelectronics, Forschungszentrum, Jülich, Germany

   RWTH Aachen University, Germany

2. Bohdan Lenyk

   Forschungszentrum Jülich

   Affiliation as printed

   Institute of Biological Information Processing (IBI-3) – Bioelectronics, Forschungszentrum, Jülich, Germany

3. Marie Jung Aachen

   Forschungszentrum Jülich · RWTH Aachen University

   Affiliation as printed

   Institute of Biological Information Processing (IBI-3) – Bioelectronics, Forschungszentrum, Jülich, Germany

   RWTH Aachen University, Germany

4. Irene Lenzi Aachen

   Forschungszentrum Jülich · RWTH Aachen University

   Affiliation as printed

   Institute of Biological Information Processing (IBI-3) – Bioelectronics, Forschungszentrum, Jülich, Germany

   RWTH Aachen University, Germany

5. Björn M. Kampa Aachen

   Forschungszentrum Jülich · Jülich Aachen Research Alliance · RWTH Aachen University

   Affiliation as printed

   JARA BRAIN Institute of Neuroscience and Medicine (INM-10), Forschungszentrum, Jülich, Germany

   RWTH Aachen University, Germany

   . RWTH Aachen University, Germany

6. Dirk Mayer

   Forschungszentrum Jülich

   Affiliation as printed

   Institute of Biological Information Processing (IBI-3) – Bioelectronics, Forschungszentrum, Jülich, Germany

7. Andreas Offenhäusser

   Forschungszentrum Jülich

   Affiliation as printed

   Institute of Biological Information Processing (IBI-3) – Bioelectronics, Forschungszentrum, Jülich, Germany

8. Simon Musall Aachen

   University of Bonn · Forschungszentrum Jülich · University Hospital Bonn · RWTH Aachen University

   Affiliation as printed

   Institute of Biological Information Processing (IBI-3) – Bioelectronics, Forschungszentrum, Jülich, Germany

   RWTH Aachen University, Germany

   University Hospital Bonn, Germany

   University of Bonn, Faculty of Medicine, Institute of Experimental Epileptology and Cognition Research, Germany

9. Viviana Rincón Montes

   Forschungszentrum Jülich

   Affiliation as printed

   Institute of Biological Information Processing (IBI-3) – Bioelectronics, Forschungszentrum, Jülich, Germany