A Brain-Wide Map of Neural Activity during Complex Behaviour
bioRxiv (Cold Spring Harbor Laboratory)
Abstract
A key challenge in neuroscience is understanding how neurons in hundreds of interconnected brain regions integrate sensory inputs with prior expectations to initiate movements and thereby make decisions. It is difficult to meet this challenge if different laboratories apply different analyses to different recordings in different regions during different behaviours. Here, we report a comprehensive set of recordings from 621733 neurons across 139 mice in 12 labs performing a decision making task with sensory, motor, and cognitive components, obtained with 699 Neuropixels probe insertions covering 279 brain areas in the left forebrain and midbrain and the right hindbrain and cerebellum. We provide an initial appraisal of this brain-wide map, assessing how neural activity encoded key task variables. Representations of visual stimuli appeared transiently in classical visual areas after stimulus onset and then spread to ramp-like activity in a collection of mid- and hindbrain regions that also encoded choices. Neural responses correlated with motor action almost everywhere in the brain. Responses to reward delivery and consumption versus negative feedback were also widespread. This publicly available dataset represents an unprecedented resource for understanding how computations distributed across and within brain areas drive behaviour.
Authors 49
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New York University · Stanford University
Affiliation as printed
Stanford University
New York University, USA
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University of Washington · New York University
Affiliation as printed
New York University
University of Washington, USA
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Champalimaud Foundation · University of Washington
Affiliation as printed
University of Washington
Champalimaud Foundation, Portugal
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Champalimaud Foundation · University College London
Affiliation as printed
Champalimaud Foundation
University College London, UK
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Champalimaud Foundation · University College London
Affiliation as printed
University College London
Champalimaud Foundation, Portugal
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University of Geneva · University of California, Los Angeles
Affiliation as printed
University of Geneva
University of California Los Angeles, USA
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University of California, Los Angeles · University of California, Berkeley
Affiliation as printed
University of California Los Angeles
University of California Berkeley, USA
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Max Planck Society · University of Tübingen · University of California, Berkeley
Affiliation as printed
University of California Berkeley
Max Planck Institute
University of Tübingen, Germany
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Peter Dayan corresponding
Champalimaud Foundation · University of Tübingen
Affiliation as printed
Max Planck Institute; University of Tübingen
Champalimaud Foundation, Portugal
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Champalimaud Foundation · Cold Spring Harbor Laboratory
Affiliation as printed
Champalimaud Foundation
Cold Spring Harbor Laboratory, NY, USA
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Champalimaud Foundation · Cold Spring Harbor Laboratory
Affiliation as printed
Cold Spring Harbor Laboratory
Champalimaud Foundation, Portugal
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Champalimaud Foundation · University College London
Affiliation as printed
Champalimaud Foundation
University College London, UK
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Princeton University · University College London
Affiliation as printed
University College London
Princeton University, USA
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University of Geneva · Princeton University
Affiliation as printed
Princeton University
University of Geneva, Switzerland
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Champalimaud Foundation · University of Geneva
Affiliation as printed
University of Geneva
Champalimaud Foundation, Portugal
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Champalimaud Foundation · University of Geneva
Affiliation as printed
Champalimaud Foundation
University of Geneva, Switzerland
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University of Geneva · University College London
Affiliation as printed
University of Geneva
University College London, UK
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Affiliation as printed
University College London
University College London, UK
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University College London · Massachusetts Institute of Technology
Affiliation as printed
University College London
Massachusetts Institute of Technology, USA
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Massachusetts Institute of Technology · University of California, Berkeley
Affiliation as printed
Massachusetts Institute of Technology
University of California Berkeley, USA
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University of Geneva · University of California, Berkeley
Affiliation as printed
University of California Berkeley
University of Geneva, Switzerland
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University of Geneva · Max Planck Society · University of Tübingen
Affiliation as printed
University of Geneva
Max Planck Institute
University of Tübingen, Germany
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University of California, Los Angeles · University of Tübingen
Affiliation as printed
Max Planck Institute; University of Tübingen
University of California Los Angeles, USA
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University of California, Los Angeles · Cold Spring Harbor Laboratory
Affiliation as printed
University of California Los Angeles
Cold Spring Harbor Laboratory, NY, USA
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Princeton University · Cold Spring Harbor Laboratory
Affiliation as printed
Cold Spring Harbor Laboratory
Princeton University, USA
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Princeton University · University College London
Affiliation as printed
Princeton University
University College London, UK
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Champalimaud Foundation · University College London
Affiliation as printed
University College London
Champalimaud Foundation, Portugal
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Affiliation as printed
Champalimaud Foundation
Champalimaud Foundation, Portugal
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Champalimaud Foundation · Sainsbury Wellcome Centre · University College London
Affiliation as printed
Champalimaud Foundation
Sainsbury Wellcome Center, University College London, UK
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Sainsbury Wellcome Centre · University College London
Affiliation as printed
Sainsbury Wellcome Center, University College London
Sainsbury Wellcome Center, University College London, UK
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University College London · New York University
Affiliation as printed
Sainsbury Wellcome Center, University College London
New York University, USA
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University of Washington · New York University
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New York University
University of Washington, USA
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Princeton University · University of Washington
Affiliation as printed
University of Washington
Princeton University, USA
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University of Geneva · Princeton University
Affiliation as printed
Princeton University
University of Geneva, Switzerland
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University of Geneva · University College London
Affiliation as printed
University of Geneva
University College London, UK
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University of Washington · University College London
Affiliation as printed
University College London
University of Washington, USA
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University of Washington · Stanford University
Affiliation as printed
University of Washington
Stanford University, USA
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Champalimaud Foundation · Stanford University
Affiliation as printed
Stanford University
Champalimaud Foundation, Portugal
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Champalimaud Foundation · Princeton University
Affiliation as printed
Champalimaud Foundation
Princeton University, USA
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Princeton University · University College London
Affiliation as printed
Princeton University
University College London, UK
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University of Washington · University College London
Affiliation as printed
University College London
University of Washington, USA
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University of Washington · Allen Institute for Neural Dynamics
Affiliation as printed
University of Washington
Allen Institute for Neural Dynamics, USA
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Karel Svoboda Aachen
Leiden University · Allen Institute for Neural Dynamics
Affiliation as printed
Allen Institute for Neural Dynamics
Leiden University, The Netherlands
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Anne E Urai Aachen
Leiden University · University College London
Affiliation as printed
Leiden University
University College London, UK
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Sainsbury Wellcome Centre · University College London
Affiliation as printed
University College London
Sainsbury Wellcome Center, University College London, UK
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University College London · Columbia University
Affiliation as printed
Sainsbury Wellcome Center, University College London
Columbia University, USA
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Champalimaud Foundation · Columbia University
Affiliation as printed
Columbia University
Champalimaud Foundation, Portugal
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Champalimaud Foundation · Princeton University
Affiliation as printed
Champalimaud Foundation
Princeton University, USA
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Affiliation as printed
Princeton University
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