A multidisciplinary lifestyle program for metabolic syndrome-associated osteoarthritis: the "Plants for Joints" randomized controlled trial
Osteoarthritis and Cartilage, vol. 31, pp. 1491–1500
Abstract
OBJECTIVE: To determine the effectiveness of the "Plants for Joints" multidisciplinary lifestyle program in patients with metabolic syndrome-associated osteoarthritis (MSOA). DESIGN: Patients with hip or knee MSOA were randomized to the intervention or control group. The intervention group followed a 16-week program in addition to usual care based on a whole food plant-based diet, physical activity, and stress management. The control group received usual care. The patient-reported Western Ontario and McMasters Universities Osteoarthritis Index (WOMAC) total score (range 0-96) was the primary outcome. Secondary outcomes included other patient-reported, anthropometric, and metabolic measures. An intention-to-treat analysis with a linear-mixed model adjusted for baseline values was used to analyze between-group differences. RESULTS: . After 16 weeks, the intervention group (n = 32) had a mean 11-point larger improvement in WOMAC-score (95% CI 6-16; p = 0.0001) compared to the control group. The intervention group also lost more weight (-5 kg), fat mass (-4 kg), and waist circumference (-6 cm) compared to the control group. Patient-Reported Outcomes Measurement Information System (PROMIS) fatigue, pain interference, C-reactive protein, hemoglobin A1c, fasting glucose, and low-density lipoproteins improved in the intervention versus the control group, while other PROMIS measures, blood pressure, high-density lipoproteins, and triglycerides did not differ significantly between the groups. CONCLUSION: The "Plants for Joints" lifestyle program reduced stiffness, relieved pain, and improved physical function in people with hip or knee MSOA compared to usual care.
Authors 11
-
Wendy Walrabenstein corresponding
Reade · Amsterdam University Medical Centers · Amsterdam University of Applied Sciences · University of Amsterdam
Affiliation as printed
Reade Center for Rheumatology and Rehabilitation, Amsterdam, the Netherlands; Department of Clinical Immunology and Rheumatology, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands; Amsterdam Rheumatology & immunology Center, Amsterdam, the Netherlands; Department of Nutrition and Dietetics, Center of Expertise Urban Vitality, Amsterdam University of Applied Sciences, Amsterdam, the Netherlands; Amsterdam Rehabilitation Research Center Reade, Amsterdam, the Netherlands. Electronic address: w.walrabenstein@reade.nl
Amsterdam Rehabilitation Research Center | Reade, Amsterdam, the Netherlands
Amsterdam Rheumatology & immunology Center, Amsterdam, the Netherlands
Department of Clinical Immunology and Rheumatology, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands
Department of Nutrition and Dietetics, Center of Expertise Urban Vitality, Amsterdam University of Applied Sciences, Amsterdam, the Netherlands
Reade Center for Rheumatology and Rehabilitation, Amsterdam, the Netherlands
-
Reade · Amsterdam University Medical Centers · University of Amsterdam
Affiliation as printed
Reade Center for Rheumatology and Rehabilitation, Amsterdam, the Netherlands; Department of Clinical Immunology and Rheumatology, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands; Amsterdam Rheumatology & immunology Center, Amsterdam, the Netherlands; Amsterdam Rehabilitation Research Center Reade, Amsterdam, the Netherlands
Amsterdam Rehabilitation Research Center | Reade, Amsterdam, the Netherlands
Amsterdam Rheumatology & immunology Center, Amsterdam, the Netherlands
Department of Clinical Immunology and Rheumatology, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands
Reade Center for Rheumatology and Rehabilitation, Amsterdam, the Netherlands
-
Affiliation as printed
Reade Center for Rheumatology and Rehabilitation, Amsterdam, the Netherlands; Amsterdam Rehabilitation Research Center Reade, Amsterdam, the Netherlands
Amsterdam Rehabilitation Research Center | Reade, Amsterdam, the Netherlands
Reade Center for Rheumatology and Rehabilitation, Amsterdam, the Netherlands
-
Reade · Amsterdam University Medical Centers · Amsterdam Movement Sciences · Vrije Universiteit Amsterdam
Affiliation as printed
Reade Center for Rheumatology and Rehabilitation, Amsterdam, the Netherlands; Department of Rehabilitation Medicine, Amsterdam UMC, Vrije Universiteit, Amsterdam, the Netherlands; Amsterdam Movement Sciences Research Institute, Amsterdam, the Netherlands; Amsterdam Rehabilitation Research Center Reade, Amsterdam, the Netherlands
Amsterdam Movement Sciences Research Institute, Amsterdam, the Netherlands
Amsterdam Rehabilitation Research Center | Reade, Amsterdam, the Netherlands
Department of Rehabilitation Medicine, Amsterdam UMC, Vrije Universiteit, Amsterdam, the Netherlands
Reade Center for Rheumatology and Rehabilitation, Amsterdam, the Netherlands
-
Affiliation as printed
Reade Center for Rheumatology and Rehabilitation, Amsterdam, the Netherlands; Amsterdam Rheumatology & immunology Center, Amsterdam, the Netherlands; Amsterdam Rehabilitation Research Center Reade, Amsterdam, the Netherlands
Amsterdam Rehabilitation Research Center | Reade, Amsterdam, the Netherlands
Amsterdam Rheumatology & immunology Center, Amsterdam, the Netherlands
Reade Center for Rheumatology and Rehabilitation, Amsterdam, the Netherlands
-
Reade · Amsterdam University Medical Centers · Vrije Universiteit Amsterdam
Affiliation as printed
Department of Epidemiology and Data Science, Amsterdam UMC, Vrije Universiteit, Amsterdam, the Netherlands; Amsterdam Rehabilitation Research Center Reade, Amsterdam, the Netherlands
Amsterdam Rehabilitation Research Center | Reade, Amsterdam, the Netherlands
Department of Epidemiology and Data Science, Amsterdam UMC, Vrije Universiteit, Amsterdam, the Netherlands
-
Reade · Amsterdam University of Applied Sciences
Affiliation as printed
Reade Center for Rheumatology and Rehabilitation, Amsterdam, the Netherlands; Center of Expertise Urban Vitality, Amsterdam University of Applied Sciences, Faculty of Health, Amsterdam, the Netherlands; Amsterdam Rehabilitation Research Center Reade, Amsterdam, the Netherlands
Amsterdam Rehabilitation Research Center | Reade, Amsterdam, the Netherlands
Center of Expertise Urban Vitality, Amsterdam University of Applied Sciences, Faculty of Health, Amsterdam, the Netherlands
Reade Center for Rheumatology and Rehabilitation, Amsterdam, the Netherlands
-
Affiliation as printed
Institute of Psychology, Health, Medical, & Neuropsychology Unit, Leiden University, Leiden, the Netherlands; Amsterdam Rehabilitation Research Center Reade, Amsterdam, the Netherlands
Amsterdam Rehabilitation Research Center | Reade, Amsterdam, the Netherlands
Institute of Psychology, Health, Medical, & Neuropsychology unit, Leiden University, Leiden, the Netherlands
-
Reade · Amsterdam University Medical Centers · Amsterdam Movement Sciences · Amsterdam University of Applied Sciences · Vrije Universiteit Amsterdam
Affiliation as printed
Department of Nutrition and Dietetics, Center of Expertise Urban Vitality, Amsterdam University of Applied Sciences, Amsterdam, the Netherlands; Amsterdam Movement Sciences Research Institute, Amsterdam, the Netherlands; Department of Nutrition & Dietetics, Amsterdam UMC, Vrije Universiteit, Amsterdam, the Netherlands; Amsterdam Rehabilitation Research Center Reade, Amsterdam, the Netherlands
Amsterdam Movement Sciences Research Institute, Amsterdam, the Netherlands
Amsterdam Rehabilitation Research Center | Reade, Amsterdam, the Netherlands
Department of Nutrition & Dietetics, Amsterdam UMC, Vrije Universiteit, Amsterdam, the Netherlands
Department of Nutrition and Dietetics, Center of Expertise Urban Vitality, Amsterdam University of Applied Sciences, Amsterdam, the Netherlands
-
Affiliation as printed
Reade Center for Rheumatology and Rehabilitation, Amsterdam, the Netherlands; Amsterdam Rehabilitation Research Center Reade, Amsterdam, the Netherlands
Amsterdam Rehabilitation Research Center | Reade, Amsterdam, the Netherlands
Reade Center for Rheumatology and Rehabilitation, Amsterdam, the Netherlands
-
Reade · Amsterdam University Medical Centers · University of Amsterdam
Affiliation as printed
Reade Center for Rheumatology and Rehabilitation, Amsterdam, the Netherlands; Department of Clinical Immunology and Rheumatology, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands; Amsterdam Rheumatology & immunology Center, Amsterdam, the Netherlands; Amsterdam Rehabilitation Research Center Reade, Amsterdam, the Netherlands
Amsterdam Rehabilitation Research Center | Reade, Amsterdam, the Netherlands
Amsterdam Rheumatology & immunology Center, Amsterdam, the Netherlands
Department of Clinical Immunology and Rheumatology, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands
Reade Center for Rheumatology and Rehabilitation, Amsterdam, the Netherlands
Cited by 36 stored of 37
No patents citing this paper on Lens.org (checked 2026-10-11).