Individual differences in delay discounting are associated with dorsal prefrontal cortex connectivity in children, adolescents, and adults

Developmental Cognitive Neuroscience, vol. 62, pp. 101265

Abstract

Delay discounting is a measure of impulsive choice relevant in adolescence as it predicts many real-life outcomes, including obesity and academic achievement. However, resting-state functional networks underlying individual differences in delay discounting during youth remain incompletely described. Here we investigate the association between multivariate patterns of functional connectivity and individual differences in impulsive choice in a large sample of children, adolescents, and adults. A total of 293 participants (9-23 years) completed a delay discounting task and underwent 3T resting-state fMRI. A connectome-wide analysis using multivariate distance-based matrix regression was used to examine whole-brain relationships between delay discounting and functional connectivity. These analyses revealed that individual differences in delay discounting were associated with patterns of connectivity emanating from the left dorsal prefrontal cortex, a default mode network hub. Greater delay discounting was associated with greater functional connectivity between the dorsal prefrontal cortex and other default mode network regions, but reduced connectivity with regions in the dorsal and ventral attention networks. These results suggest delay discounting in children, adolescents, and adults is associated with individual differences in relationships both within the default mode network and between the default mode and networks involved in attentional and cognitive control.

Authors 17

1. Kahini P. Mehta

   University of Pennsylvania

   Affiliation as printed

   Lifespan Informatics and Neuroimaging Center (PennLINC), Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, 19104, USA

   Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, 19104, USA

   Lifespan Informatics and Neuroimaging Center (PennLINC), Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA

2. Adam Robert Pines

   University of Pennsylvania

   Affiliation as printed

   Lifespan Informatics and Neuroimaging Center (PennLINC), Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, 19104, USA

   Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, 19104, USA

   Lifespan Informatics and Neuroimaging Center (PennLINC), Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA

3. Azeez Adebimpe

   University of Pennsylvania

   Affiliation as printed

   Lifespan Informatics and Neuroimaging Center (PennLINC), Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, 19104, USA

   Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, 19104, USA

   Lifespan Informatics and Neuroimaging Center (PennLINC), Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA

4. Bart L. Larsen

   University of Pennsylvania

   Affiliation as printed

   Lifespan Informatics and Neuroimaging Center (PennLINC), Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, 19104, USA

   Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, 19104, USA

   Lifespan Informatics and Neuroimaging Center (PennLINC), Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA

5. Danielle S. Bassett

   Santa Fe Institute · University of Pennsylvania

   Affiliation as printed

   Department of Bioengineering, School of Engineering and Applied Science, University of Pennsylvania, PA 19104, USA; Department of Electrical & Systems Engineering, University of Pennsylvania, PA 19104, USA; Department of Neurology, University of Pennsylvania, Philadelphia, PA, 19104, USA; Department of Physics & Astronomy, University of Pennsylvania, Philadelphia, PA, 19104, USA; Santa Fe Institute, Santa Fe, NM, 87051, USA

   Department of Bioengineering, School of Engineering and Applied Science, University of Pennsylvania, PA 19104, USA

   Department of Electrical & Systems Engineering, University of Pennsylvania, PA 19104, USA

   Department of Neurology, University of Pennsylvania, Philadelphia, PA, 19104, USA

   Department of Physics & Astronomy, University of Pennsylvania, Philadelphia, PA, 19104, USA

   Santa Fe Institute, Santa Fe, NM, 87051, USA

6. Monica E. Calkins

   University of Pennsylvania

   Affiliation as printed

   Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, 19104, USA

7. Erica B. Baller

   University of Pennsylvania

   Affiliation as printed

   Lifespan Informatics and Neuroimaging Center (PennLINC), Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, 19104, USA

   Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, 19104, USA

   Lifespan Informatics and Neuroimaging Center (PennLINC), Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA

8. Martin Gell Aachen Department of Psychiatry, Psychotherapy and Psychosomatics Medical Faculty

   Forschungszentrum Jülich · University of Pennsylvania · RWTH Aachen University

   Affiliation as printed

   Lifespan Informatics and Neuroimaging Center (PennLINC), Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Psychiatry, Psychotherapy and Psychosomatics, Medical Faculty, RWTH Aachen University, Aachen, Germany; Institute of Neuroscience and Medicine (INM-7: Brain & Behaviour), Research Centre Jülich, Jülich, Germany

   Department of Psychiatry, Psychotherapy and Psychosomatics, Medical Faculty, RWTH Aachen University, Aachen, Germany

   Institute of Neuroscience and Medicine (INM-7: Brain & Behaviour), Research Centre Jülich, Jülich, Germany

   Lifespan Informatics and Neuroimaging Center (PennLINC), Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA

9. Lauren M. Patrick

   University of Pennsylvania

   Affiliation as printed

   Department of Psychology, University of Pennsylvania, Philadelphia, PA 19104, USA

10. Golia Shafiei

    University of Pennsylvania

    Affiliation as printed

    Lifespan Informatics and Neuroimaging Center (PennLINC), Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, 19104, USA

    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, 19104, USA

    Lifespan Informatics and Neuroimaging Center (PennLINC), Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA

11. Raquel E. Gur

    Children's Hospital of Philadelphia · University of Pennsylvania

    Affiliation as printed

    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, 19104, USA; Penn/CHOP Lifespan Brain Institute, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Neurology, University of Pennsylvania, Philadelphia, PA, 19104, USA

    Department of Neurology, University of Pennsylvania, Philadelphia, PA, 19104, USA

    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, 19104, USA

    Penn/CHOP Lifespan Brain Institute, University of Pennsylvania, Philadelphia, PA 19104, USA

12. Ruben C. Gur

    Children's Hospital of Philadelphia · University of Pennsylvania

    Affiliation as printed

    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, 19104, USA; Penn/CHOP Lifespan Brain Institute, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Neurology, University of Pennsylvania, Philadelphia, PA, 19104, USA

    Department of Neurology, University of Pennsylvania, Philadelphia, PA, 19104, USA

    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, 19104, USA

    Penn/CHOP Lifespan Brain Institute, University of Pennsylvania, Philadelphia, PA 19104, USA

13. David R. Roalf

    University of Pennsylvania

    Affiliation as printed

    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, 19104, USA

14. Daniel Römer

    University of Pennsylvania

    Affiliation as printed

    Annenberg Public Policy Center, University of Pennsylvania, Philadelphia, PA 19104, USA

15. Daniel H. Wolf

    University of Pennsylvania

    Affiliation as printed

    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, 19104, USA

16. Joseph W. Kable

    University of Pennsylvania

    Affiliation as printed

    Department of Psychology, University of Pennsylvania, Philadelphia, PA 19104, USA

17. Theodore Daniel Satterthwaite corresponding

    Children's Hospital of Philadelphia · University of Pennsylvania

    Affiliation as printed

    Lifespan Informatics and Neuroimaging Center (PennLINC), Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, 19104, USA; Penn/CHOP Lifespan Brain Institute, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: sattertt@pennmedicine.upenn.edu

    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, 19104, USA

    Lifespan Informatics and Neuroimaging Center (PennLINC), Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA

    Penn/CHOP Lifespan Brain Institute, University of Pennsylvania, Philadelphia, PA 19104, USA