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June 07, 2023 preprint Open access Aachen paper

QRAGE – Simultaneous multiparametric quantitative MRI at ultrahigh field strength

DOI: 10.36227/techrxiv.23302574 Full text (OA) OpenAlex

Abstract

QRAGE is a novel imaging sequence and reconstruction method for the simultaneous mapping of multiple quantitative MRI parameters, including water content, T1, T2*, and magnetic susceptibility at ultrahigh field strength. QRAGE employs a novel ME-MPnRAGE sequence that acquires 171 contrast images at different inversion and echo time points, enabling accurate and precise parameter estimation. It further incorporates a novel model-based reconstruction method, MIRAGE2, that leverages prior knowledge of temporal signal evolution represented as damped complex exponentials by minimizing local Block-Hankel and Casorati matrices. Parameter maps are derived from the reconstructed contrast images through postprocessing steps.

Authors 8

  1. Markus Zimmermann corresponding Aachen Department of Neurology

    Forschungszentrum Jülich · Jülich Aachen Research Alliance · RWTH Aachen University

    Affiliation as printed

    Institute of Neuroscience and Medicine 4 , INM-4 , Forschungszentrum J ülich , Germany , J ülich , Germany

    Department of Neurology, RWTH Aachen University, Aachen, Germany, Aachen, Germany

    Institute of Neuroscience and Medicine 4, INM-4, Forschungszentrum J ülich, Germany,

    Institute of Neuroscience and Medicine 4, INM-4, Forschungszentrum J ülich, Germany, J ülich, Germany

    J ülich, Germany,

    J ülich, Germany, the Institute of Neuroscience and Medicine 11, INM-11,

    JARA -BRAIN -Transla-tional Medicine, Aachen, Germany, Aachen, Germany

    JARA, Forschungszen-trum J ülich, Germany,

  2. Zaheer Abbas Aachen Department of Neurology

    Forschungszentrum Jülich · Jülich Aachen Research Alliance · RWTH Aachen University

    Affiliation as printed

    Institute of Neuroscience and Medicine 4 , INM-4 , Forschungszentrum J ülich , Germany , J ülich , Germany

    Department of Neurology, RWTH Aachen University, Aachen, Germany, Aachen, Germany

    Institute of Neuroscience and Medicine 4, INM-4, Forschungszentrum J ülich, Germany,

    Institute of Neuroscience and Medicine 4, INM-4, Forschungszentrum J ülich, Germany, J ülich, Germany

    J ülich, Germany,

    J ülich, Germany, the Institute of Neuroscience and Medicine 11, INM-11,

    JARA -BRAIN -Transla-tional Medicine, Aachen, Germany, Aachen, Germany

    JARA, Forschungszen-trum J ülich, Germany,

  3. Yannic Sommer Aachen Department of Neurology

    Forschungszentrum Jülich · Jülich Aachen Research Alliance · RWTH Aachen University

    Affiliation as printed

    Institute of Neuroscience and Medicine 4 , INM-4 , Forschungszentrum J ülich , Germany , J ülich , Germany

    Department of Neurology, RWTH Aachen University, Aachen, Germany, Aachen, Germany

    Institute of Neuroscience and Medicine 4, INM-4, Forschungszentrum J ülich, Germany,

    Institute of Neuroscience and Medicine 4, INM-4, Forschungszentrum J ülich, Germany, J ülich, Germany

    J ülich, Germany,

    J ülich, Germany, the Institute of Neuroscience and Medicine 11, INM-11,

    JARA -BRAIN -Transla-tional Medicine, Aachen, Germany, Aachen, Germany

    JARA, Forschungszen-trum J ülich, Germany,

  4. Alexander Lewin Aachen Department of Neurology

    Forschungszentrum Jülich · Jülich Aachen Research Alliance · RWTH Aachen University

    Affiliation as printed

    Institute of Neuroscience and Medicine 4 , INM-4 , Forschungszentrum J ülich , Germany , J ülich , Germany

    Department of Neurology, RWTH Aachen University, Aachen, Germany, Aachen, Germany

    Institute of Neuroscience and Medicine 4, INM-4, Forschungszentrum J ülich, Germany,

    Institute of Neuroscience and Medicine 4, INM-4, Forschungszentrum J ülich, Germany, J ülich, Germany

    J ülich, Germany,

    J ülich, Germany, the Institute of Neuroscience and Medicine 11, INM-11,

    JARA -BRAIN -Transla-tional Medicine, Aachen, Germany, Aachen, Germany

    JARA, Forschungszen-trum J ülich, Germany,

  5. Shukti Ramkiran Aachen Department of Neurology

    Forschungszentrum Jülich · Jülich Aachen Research Alliance · RWTH Aachen University

    Affiliation as printed

    Institute of Neuroscience and Medicine 4 , INM-4 , Forschungszentrum J ülich , Germany , J ülich , Germany

    Department of Neurology, RWTH Aachen University, Aachen, Germany, Aachen, Germany

    Institute of Neuroscience and Medicine 4, INM-4, Forschungszentrum J ülich, Germany,

    Institute of Neuroscience and Medicine 4, INM-4, Forschungszentrum J ülich, Germany, J ülich, Germany

    J ülich, Germany,

    J ülich, Germany, the Institute of Neuroscience and Medicine 11, INM-11,

    JARA -BRAIN -Transla-tional Medicine, Aachen, Germany, Aachen, Germany

    JARA, Forschungszen-trum J ülich, Germany,

  6. Ana‐Maria Oros‐Peusquens Aachen Department of Neurology

    Forschungszentrum Jülich · Jülich Aachen Research Alliance · RWTH Aachen University

    Affiliation as printed

    Institute of Neuroscience and Medicine 4 , INM-4 , Forschungszentrum J ülich , Germany , J ülich , Germany

    Department of Neurology, RWTH Aachen University, Aachen, Germany, Aachen, Germany

    Institute of Neuroscience and Medicine 4, INM-4, Forschungszentrum J ülich, Germany,

    Institute of Neuroscience and Medicine 4, INM-4, Forschungszentrum J ülich, Germany, J ülich, Germany

    J ülich, Germany,

    J ülich, Germany, the Institute of Neuroscience and Medicine 11, INM-11,

    JARA -BRAIN -Transla-tional Medicine, Aachen, Germany, Aachen, Germany

    JARA, Forschungszen-trum J ülich, Germany,

  7. Seong Dae Yun Aachen Department of Neurology

    Forschungszentrum Jülich · Jülich Aachen Research Alliance · RWTH Aachen University

    Affiliation as printed

    Department of Neurology, RWTH Aachen University, Aachen, Germany, Aachen, Germany

    Institute of Neuroscience and Medicine 4, INM-4, Forschungszentrum J ülich, Germany,

    Institute of Neuroscience and Medicine 4, INM-4, Forschungszentrum J ülich, Germany, J ülich, Germany

    J ülich, Germany,

    J ülich, Germany, the Institute of Neuroscience and Medicine 11, INM-11,

    JARA -BRAIN -Transla-tional Medicine, Aachen, Germany, Aachen, Germany

    JARA, Forschungszen-trum J ülich, Germany,

  8. Nadim Jon Shah Aachen Department of Neurology

    Forschungszentrum Jülich · Jülich Aachen Research Alliance · RWTH Aachen University

    Affiliation as printed

    Institute of Neuroscience and Medicine 4 , INM-4 , Forschungszentrum J ülich , Germany , J ülich , Germany

    Department of Neurology, RWTH Aachen University, Aachen, Germany, Aachen, Germany

    Institute of Neuroscience and Medicine 4, INM-4, Forschungszentrum J ülich, Germany,

    Institute of Neuroscience and Medicine 4, INM-4, Forschungszentrum J ülich, Germany, J ülich, Germany

    J ülich, Germany,

    J ülich, Germany, the Institute of Neuroscience and Medicine 11, INM-11,

    JARA -BRAIN -Transla-tional Medicine, Aachen, Germany, Aachen, Germany

    JARA, Forschungszen-trum J ülich, Germany,

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References 43