Mycobacterial type VII secretion systems

Biological Chemistry, vol. 404, pp. 691–702

Abstract

, utilize up to five paralogous type VII secretion systems to transport proteins across their cell envelope. Since these proteins associate in pairs that depend on each other for transport to a different extent, the secretion pathway to the bacterial surface remained challenging to address. Structural characterization of the inner-membrane embedded secretion machineries along with recent advances on the substrates' co-dependencies for transport allow for the first time more detailed and testable models for secretion.

Authors 3

1. Nikolaos Famelis corresponding

   University of Würzburg

   Affiliation as printed

   Institute for Molecular Infection Biology, Julius Maximilian University of Würzburg , D-97080 Würzburg , Germany

2. Sebastian Geibel corresponding Aachen

   Leiden University

   Affiliation as printed

   Leiden Institute of Chemistry, Leiden University , NL-2333 CC Leiden , Netherlands

3. Daan J. C. van Tol Aachen

   Leiden University

   Affiliation as printed

   Leiden Institute of Chemistry, Leiden University , NL-2333 CC Leiden , Netherlands