Image registration and mutual thresholding enable low interimage variability across dynamic MRI measurements of supraclavicular brown adipose tissue during mild cold exposure
Magnetic Resonance in Medicine, vol. 90, pp. 1316–1327
Abstract
PURPOSE: Activated brown adipose tissue (BAT) enhances lipid catabolism and improves cardiometabolic health. Quantitative MRI of the fat fraction (FF) of supraclavicular BAT (scBAT) is a promising noninvasive measure to assess BAT activity but suffers from high scan variability. We aimed to test the effects of coregistration and mutual thresholding on the scan variability in a fast (1 min) time-resolution MRI protocol for assessing scBAT FF changes during cold exposure. METHODS: ) were scanned during thermoneutrality (32°C; 10 min) and mild cold exposure (18°C; 60 min) using a 12-point gradient-echo sequence (70 consecutive scans with breath-holds, 1.03 min per dynamic). Dynamics were coregistered to the first thermoneutral scan, which enabled drawing of single regions of interest in the scBAT depot. Voxel-wise FF changes were calculated at each time point and averaged across regions of interest. We applied mutual FF thresholding, in which voxels were included if their FF was greater than 30% FF in the reference scan and the registered dynamic. The efficacy of the coregistration was determined by using a moving average and comparing the mean squared error of residuals between registered and nonregistered data. Registered scBAT ΔFF was compared with single-scan thresholding using the moving average method. RESULTS: Registered scBAT ΔFF had lower mean square error values than nonregistered data (0.07 ± 0.05% vs. 0.16 ± 0.14%; p < 0.05), and mutual thresholding reduced the scBAT ΔFF variability by 30%. CONCLUSION: We demonstrate that coregistration and mutual thresholding improve stability of the data 2-fold, enabling assessment of small changes in FF following cold exposure.
Authors 8
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Aashley S. D. Sardjoe Mishre Aachen Department of Medicine Division of Endocrinology Leiden University Medical Center Leiden The Netherlands Department of Radiology Division of Endocrinology, Leiden University Medical Center Department of Radiology, C.J. Gorter MRI Centre Einthoven Laboratory for Experimental Vascular Medicine
Leiden University Medical Center
Affiliation as printed
Department of Medicine, Division of Endocrinology Leiden University Medical Center Leiden the Netherlands
Department of Radiology, C.J. Gorter MRI Center Leiden University Medical Center Leiden the Netherlands
Einthoven Laboratory for Experimental Vascular Medicine Leiden University Medical Center Leiden the Netherlands
Department of Medicine, Division of Endocrinology, Leiden University Medical Center, Leiden, the Netherlands
Department of Radiology, C.J. Gorter MRI Center, Leiden University Medical Center, Leiden, the Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, the Netherlands
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Borja Martínez‐Téllez Aachen Department of Medicine Division of Endocrinology Leiden University Medical Center Leiden The Netherlands Division of Endocrinology, Leiden University Medical Center Einthoven Laboratory for Experimental Vascular Medicine
Leiden University Medical Center
Affiliation as printed
Department of Medicine, Division of Endocrinology Leiden University Medical Center Leiden the Netherlands
Einthoven Laboratory for Experimental Vascular Medicine Leiden University Medical Center Leiden the Netherlands
Department of Medicine, Division of Endocrinology, Leiden University Medical Center, Leiden, the Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, the Netherlands
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Maaike E. Straat Aachen Department of Medicine Division of Endocrinology Leiden University Medical Center Leiden The Netherlands Division of Endocrinology, Leiden University Medical Center Einthoven Laboratory for Experimental Vascular Medicine
Leiden University Medical Center
Affiliation as printed
Department of Medicine, Division of Endocrinology Leiden University Medical Center Leiden the Netherlands
Einthoven Laboratory for Experimental Vascular Medicine Leiden University Medical Center Leiden the Netherlands
Department of Medicine, Division of Endocrinology, Leiden University Medical Center, Leiden, the Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, the Netherlands
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Mariëtte R. Boon Aachen Department of Medicine Division of Endocrinology Leiden University Medical Center Leiden The Netherlands Division of Endocrinology, Leiden University Medical Center Einthoven Laboratory for Experimental Vascular Medicine
Leiden University Medical Center
Affiliation as printed
Department of Medicine, Division of Endocrinology Leiden University Medical Center Leiden the Netherlands
Einthoven Laboratory for Experimental Vascular Medicine Leiden University Medical Center Leiden the Netherlands
Department of Medicine, Division of Endocrinology, Leiden University Medical Center, Leiden, the Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, the Netherlands
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Oleh Dzyubachyk Aachen Department of Cell and Chemical Biology Department of Radiology Division of Image Processing (LKEB) Leiden University Medical Center Leiden the Netherlands Electron Microscopy Section Division of Image Processing (LKEB)
Leiden University Medical Center
Affiliation as printed
Department of Cell and Chemical Biology, Electron Microscopy Section Leiden University Medical Center Leiden the Netherlands
Department of Radiology, Division of Image Processing Leiden University Medical Center Leiden the Netherlands
Department of Cell and Chemical Biology, Electron Microscopy Section, Leiden University Medical Center, Leiden, the Netherlands
Department of Radiology, Division of Image Processing, Leiden University Medical Center, Leiden, the Netherlands
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Leiden University Medical Center
Affiliation as printed
Department of Radiology, C.J. Gorter MRI Center Leiden University Medical Center Leiden the Netherlands
Department of Radiology, C.J. Gorter MRI Center, Leiden University Medical Center, Leiden, the Netherlands
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Patrick C.N. Rensen Aachen Department of Medicine Division of Endocrinology Leiden University Medical Center Leiden The Netherlands Division of Endocrinology, Leiden University Medical Center Einthoven Laboratory for Experimental Vascular Medicine
Leiden University Medical Center
Affiliation as printed
Department of Medicine, Division of Endocrinology Leiden University Medical Center Leiden the Netherlands
Einthoven Laboratory for Experimental Vascular Medicine Leiden University Medical Center Leiden the Netherlands
Department of Medicine, Division of Endocrinology, Leiden University Medical Center, Leiden, the Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, the Netherlands
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Hermien E. Kan corresponding Aachen Department of Radiology Department of Radiology, C.J. Gorter MRI Centre
Leiden University Medical Center
Affiliation as printed
Department of Radiology, C.J. Gorter MRI Center Leiden University Medical Center Leiden the Netherlands
Department of Radiology, C.J. Gorter MRI Center, Leiden University Medical Center, Leiden, the Netherlands
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