Development and External Validation of a PET Radiomic Model for Prognostication of Head and Neck Cancer

Cancers, vol. 15, pp. 2681

Abstract

AIM: F]FDG PET radiomic model to predict overall survival in patients with head and neck squamous cell carcinoma (HNSCC). METHODS: F]FDG PET/CT scan were included (EORTC: n = 20, Unicancer: n = 34). Tumours were delineated, and radiomic features were extracted. Each cohort served once as a training and once as an external validation set for the prediction of overall survival. Supervised feature selection was performed using variable hunting with variable importance, selecting the top two features. A Cox proportional hazards regression model using selected radiomic features and clinical characteristics was fitted on the training dataset and validated in the external validation set. Model performances are expressed by the concordance index (C-index). RESULTS: In both models, the radiomic model surpassed the clinical model with validation C-indices of 0.69 and 0.79 vs. 0.60 and 0.67, respectively. The model that combined the radiomic features and clinical variables performed best, with validation C-indices of 0.71 and 0.82. CONCLUSION: F]FDG-PET radiomic signature based on the evaluation scan seems promising for the prediction of overall survival for HNSSC treated with preoperative afatinib. The robustness and clinical applicability of this radiomic signature should be assessed in a larger cohort.

Authors 20

1. Wyanne A. Noortman corresponding Aachen Section of Nuclear Medicine Department of Radiology, Leiden University Medical Center

   Leiden University Medical Center · University of Twente

   Affiliation as printed

   Section of Nuclear Medicine, Department of Radiology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands

   TechMed Centre, University of Twente, 7522 NB Enschede, The Netherlands

2. Nicolas Aide

   Centre Hospitalier Universitaire de Caen Normandie

   Affiliation as printed

   Nuclear Medicine Department, Centre Hospitalier Universitaire de Caen, 14000 Caen, France

3. Dennis Vriens Aachen Section of Nuclear Medicine Department of Radiology, Leiden University Medical Center

   Leiden University Medical Center

   Affiliation as printed

   Section of Nuclear Medicine, Department of Radiology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands

4. Lisa S. Arkes Aachen Section of Nuclear Medicine Department of Radiology, Leiden University Medical Center

   Leiden University Medical Center · Delft University of Technology

   Affiliation as printed

   Section of Nuclear Medicine, Department of Radiology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands

   Technical Medicine, Delft University of Technology, 2628 CD Delft, The Netherlands

5. Cornelis Herman Slump

   University of Twente

   Affiliation as printed

   TechMed Centre, University of Twente, 7522 NB Enschede, The Netherlands

6. Ronald Boellaard

   Amsterdam University Medical Centers

   Affiliation as printed

   Amsterdam University Medical Center, 1081 HV Amsterdam, The Netherlands

7. Jelle J. Goeman Aachen Department of Biomedical Data Sciences

   Leiden University Medical Center

   Affiliation as printed

   Department of Biomedical Data Sciences, Leiden University Medical Center, 2300 RC Leiden, The Netherlands

8. Christophe M. Deroose

   Universitair Ziekenhuis Leuven · KU Leuven

   Affiliation as printed

   Nuclear Medicine and Molecular Imaging, Department of Imaging & Pathology, University Hospitals Leuven, KU Leuven, 3000 Leuven, Belgium

9. Jean‐Pascal Machiels

   Cliniques Universitaires Saint-Luc · UCLouvain

   Affiliation as printed

   Department of Medical Oncology, Institut Roi Albert II, Cliniques Universitaires Saint-Luc, 1200 Brussels, Belgium

   Institute for Experimental and Clinical Research (IREC, pôle MIRO), Université Catholique de Louvain (UCLouvain), 1200 Brussels, Belgium

10. Lisa Francesca Licitra

    University of Milan · Fondazione IRCCS Istituto Nazionale dei Tumori

    Affiliation as printed

    Department of Head and Neck Medical Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori, University of Milan, 20133 Milan, Italy

11. Renaud Lhommel

    Cliniques Universitaires Saint-Luc

    Affiliation as printed

    Division of Nuclear Medicine, Institut de Recherche Clinique, Cliniques Universitaires Saint Luc, 1200 Brussels, Belgium

12. Alessandra Alessi

    Fondazione IRCCS Istituto Nazionale dei Tumori

    Affiliation as printed

    Department of Nuclear Medicine-PET Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, 20133 Milan, Italy

13. Erwin Woff

    Université Libre de Bruxelles · Institut Jules Bordet

    Affiliation as printed

    Nuclear Medicine Department, Institut Jules Bordet, Université Libre de Bruxelles (ULB), Hôpital Universitaire de Bruxelles (H.U.B.), 1070 Bruxelles, Belgium

14. Karolien E. Goffin

    Universitair Ziekenhuis Leuven · KU Leuven

    Affiliation as printed

    Nuclear Medicine and Molecular Imaging, Department of Imaging & Pathology, University Hospitals Leuven, KU Leuven, 3000 Leuven, Belgium

15. Christophe Le Tourneau

    Université Paris-Saclay · Institut Curie

    Affiliation as printed

    Department of Drug Development and Innovation, Institut Curie, Paris-Saclay University, 75005 Paris, France

16. Jocelyn Gal

    Université Côte d'Azur · Centre Antoine Lacassagne

    Affiliation as printed

    Epidemiology and Biostatistics Department, Centre Antoine Lacassagne, University Côte d’Azur, 06100 Nice, France

17. Stéphane Temam

    Institut Gustave Roussy

    Affiliation as printed

    Department of Head and Neck Surgery Gustave Roussy, 94805 Villejuif, France

18. Jean‐Pierre Delord

    Institut universitaire du cancer de Toulouse Oncopole

    Affiliation as printed

    Department of Medical Oncology, IUCT-Oncopole, 31100 Toulouse, France

19. Floris H. P. van Velden Aachen Section of Nuclear Medicine Department of Radiology, Leiden University Medical Center

    Leiden University Medical Center

    Affiliation as printed

    Section of Nuclear Medicine, Department of Radiology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands

20. Lioe‐Fee de Geus‐Oei Aachen Section of Nuclear Medicine Department of Radiology, Leiden University Medical Center

    Leiden University Medical Center · University of Twente · Delft University of Technology

    Affiliation as printed

    Department of Radiation Science & Technology, Delft University of Technology, 2628 CD Delft, The Netherlands

    Section of Nuclear Medicine, Department of Radiology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands

    TechMed Centre, University of Twente, 7522 NB Enschede, The Netherlands