Perspectives on validation of clinical predictive algorithms

npj Digital Medicine, vol. 6, pp. 86

Abstract

The generalizability of predictive algorithms is of key relevance to application in clinical practice. We provide an overview of three types of generalizability, based on existing literature: temporal, geographical, and domain generalizability. These generalizability types are linked to their associated goals, methodology, and stakeholders.

Authors 6

1. Anne de Hond corresponding Aachen Clinical AI Implementation and Research Lab Department of Biomedical Data Sciences

   Leiden University · Leiden University Medical Center · Stanford Medicine · Stanford University

   Affiliation as printed

   Clinical AI Implementation and Research Lab, Leiden University Medical Centre, Leiden, the Netherlands. a.a.h.de_hond@lumc.nl

   Department of Biomedical Data Sciences, Leiden University Medical Centre, Leiden, the Netherlands. a.a.h.de_hond@lumc.nl

   Department of Medicine (Biomedical Informatics), Stanford University, Stanford, CA, USA. a.a.h.de_hond@lumc.nl

   Clinical AI Implementation and Research Lab, Leiden University Medical Centre, Leiden, the Netherlands

2. Vaibhavi B. Shah

   Stanford Medicine · Stanford University

   Affiliation as printed

   Department of Medicine (Biomedical Informatics), Stanford University, Stanford, CA, USA

3. Ilse M.J. Kant

   University Medical Center Utrecht

   Affiliation as printed

   Department of Digital Health, University Medical Center Utrecht, Utrecht, the Netherlands

4. Ben Van Calster Aachen Department of Biomedical Data Sciences

   Leiden University · Leiden University Medical Center · KU Leuven

   Affiliation as printed

   Department of Biomedical Data Sciences, Leiden University Medical Centre, Leiden, the Netherlands

   Department of Development & Regeneration, KU Leuven, Leuven, Belgium

5. Ewout Willem Steyerberg Aachen Clinical AI Implementation and Research Lab Department of Biomedical Data Sciences

   Leiden University · Leiden University Medical Center

   Affiliation as printed

   Clinical AI Implementation and Research Lab, Leiden University Medical Centre, Leiden, the Netherlands

   Department of Biomedical Data Sciences, Leiden University Medical Centre, Leiden, the Netherlands

6. Tina Hernandez‐Boussard

   Stanford Medicine · Stanford University

   Affiliation as printed

   Department of Biomedical Data Science, Stanford University, Stanford, CA, USA

   Department of Epidemiology & Population Health (by courtesy), Stanford University, Stanford, CA, USA

   Department of Medicine (Biomedical Informatics), Stanford University, Stanford, CA, USA