Noninvasive detection of soft tissue sarcoma using volatile organic compounds in exhaled breath: a pilot study
Future Oncology, vol. 19, pp. 697–704
Abstract
Aim: The aim of this pilot study was to assess whether an electronic nose can detect patients with soft tissue sarcoma (STS) based on volatile organic compound profiles in exhaled breath. Patients & methods: In this cross-sectional pilot study, patients with primary STS and healthy controls, matched on sex and age, were included for breath analysis. Machine learning techniques were used to develop the best-fitting model. Results: Fifty-nine breath samples were collected (29 STS and 30 control) from March 2018 to March 2022. The final model yielded a c-statistic of 0.85 with a sensitivity of 83% and specificity of 60%. Conclusion: This study suggests that exhaled volatile organic compound analysis could serve as a noninvasive diagnostic biomarker for the detection of STS with a good performance.
Authors 8
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Leiden University · Leiden University Medical Center · Erasmus MC Cancer Institute
Affiliation as printed
Department of Orthopedic Oncology,Leiden University Medical Centre, Albinusdreef 2, Leiden, 2333, ZA, The Netherlands
Department of Surgical Oncology & Gastrointestinal Surgery,Erasmus MC Cancer Institute, Dr. Molewaterplein 40, Rotterdam, 3015, GD, The Netherlands
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Leiden University · Leiden University Medical Center
Affiliation as printed
Department of Orthopedic Oncology,Leiden University Medical Centre, Albinusdreef 2, Leiden, 2333, ZA, The Netherlands
Department of Orthopedic Oncology, Leiden University Medical Centre, Albinusdreef 2, Leiden, 2333, ZA, The Netherlands
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Leiden University · Leiden University Medical Center
Affiliation as printed
Department of Orthopedic Oncology,Leiden University Medical Centre, Albinusdreef 2, Leiden, 2333, ZA, The Netherlands
Department of Orthopedic Oncology, Leiden University Medical Centre, Albinusdreef 2, Leiden, 2333, ZA, The Netherlands
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Leiden University · Leiden University Medical Center
Affiliation as printed
Department of Orthopedic Oncology,Leiden University Medical Centre, Albinusdreef 2, Leiden, 2333, ZA, The Netherlands
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Leiden University · Leiden University Medical Center
Affiliation as printed
Department of Orthopedic Oncology,Leiden University Medical Centre, Albinusdreef 2, Leiden, 2333, ZA, The Netherlands
Department of Orthopedic Oncology, Leiden University Medical Centre, Albinusdreef 2, Leiden, 2333, ZA, The Netherlands
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Leiden University · Leiden University Medical Center · Erasmus MC Cancer Institute
Affiliation as printed
Department of Surgical Oncology & Gastrointestinal Surgery,Erasmus MC Cancer Institute, Dr. Molewaterplein 40, Rotterdam, 3015, GD, The Netherlands
Department of Orthopedic Oncology, Leiden University Medical Centre, Albinusdreef 2, Leiden, 2333, ZA, The Netherlands
-
Leiden University · Leiden University Medical Center · Erasmus MC Cancer Institute
Affiliation as printed
Department of Surgical Oncology & Gastrointestinal Surgery,Erasmus MC Cancer Institute, Dr. Molewaterplein 40, Rotterdam, 3015, GD, The Netherlands
Department of Orthopedic Oncology, Leiden University Medical Centre, Albinusdreef 2, Leiden, 2333, ZA, The Netherlands
-
Leiden University · Leiden University Medical Center · Erasmus MC Cancer Institute
Affiliation as printed
Department of Orthopedic Oncology,Leiden University Medical Centre, Albinusdreef 2, Leiden, 2333, ZA, The Netherlands
Department of Orthopedic Oncology, Leiden University Medical Centre, Albinusdreef 2, Leiden, 2333, ZA, The Netherlands
Department of Surgical Oncology & Gastrointestinal Surgery, Erasmus MC Cancer Institute, Dr. Molewaterplein 40, Rotterdam, 3015, GD, The Netherlands
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