HSCT: How Does It Work?

Springer eBooks, pp. 25–43

Abstract

Abstract The HSCT (haematopoietic stem cell transplant) is a particular treatment for many haematological and non-haematological diseases. Broadly, there are three different categories of transplantation, autologous, allogeneic and syngeneic, which can be applied to most disease scenarios. Haematopoietic stem cells can be derived from the bone marrow, peripheral blood and umbilical cord blood. HSCT treatment can be divided into separate phases that start with the harvest of the stem cells and passing through the conditioning, aplasia and engraftment until the recovery of the haematopoietic functions. HSCT is indicated in many diseases, and these indications depend on numerous factors such as the disease type, stage and response to previous treatment. This chapter includes transplant in primary immunodeficiency in children, haemoglobinopathies as well as inherited bone marrow failure and inborn errors of metabolism.

Authors 3

1. Letizia Galgano corresponding

   Azienda Ospedaliero-Universitaria Careggi

   Affiliation as printed

   Department of Transfusion Service and Cell Therapy BMT Unit, AOU Careggi Hospital, Florence, Italy

2. Daphna Hutt

   Sheba Medical Center · Edmond and Lily Safra Children's Hospital

   Affiliation as printed

   Department of Pediatric Hematology-Oncology and BMT, Edmond and Lily Safra Children Hospital, Sheba Medical Center, Tel-Hashomer, Israel

3. Hilda Mekelenkamp Aachen Department of Pediatrics, Willem-Alexander Children's Hospital

   Leiden University Medical Center · Willem-Alexander Kinderziekenhuis

   Affiliation as printed

   Department of Pediatrics, Willem-Alexander Children’s Hospital, Leiden University Medical Center, Leiden, The Netherlands

   Department of Pediatrics, Willem-Alexander Children's Hospital, Leiden University Medical Center, Leiden, The Netherlands