MR Vascular Fingerprinting with Hybrid Gradient–Spin Echo Dynamic Susceptibility Contrast MRI for Characterization of Microvasculature in Gliomas
Cancers, vol. 15, pp. 2180
Abstract
Characterization of tumor microvasculature is important in tumor assessment and studying treatment response. This is possible by acquiring vascular biomarkers with magnetic resonance imaging (MRI) based on dynamic susceptibility contrast (DSC). We propose magnetic resonance vascular fingerprinting (MRVF) for hybrid echo planar imaging (HEPI) acquired during the first passage of the contrast agent (CA). The proposed approach was evaluated in patients with gliomas, and we simultaneously estimated vessel radius and relative cerebral blood volume. These parameters were also compared to the respective values estimated using the previously introduced vessel size imaging (VSI) technique. The results of both methods were found to be consistent. MRVF was also found to be robust to noise in the estimation of the parameters. DSC-HEPI-based MRVF provides characterization of microvasculature in gliomas with a short acquisition time and can be further improved in several ways to increase our understanding of tumor physiology.
Authors 8
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Krishnapriya Venugopal corresponding
Erasmus MC · Erasmus MC Cancer Institute
Affiliation as printed
Department of Radiology and Nuclear Medicine, Erasmus MC, University Medical Center Rotterdam, 3015 GD Rotterdam, The Netherlands
Erasmus MC Cancer Institute, Erasmus MC, 3015 GD Rotterdam, The Netherlands
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Erasmus MC · Erasmus MC Cancer Institute
Affiliation as printed
Department of Radiology and Nuclear Medicine, Erasmus MC, University Medical Center Rotterdam, 3015 GD Rotterdam, The Netherlands
Erasmus MC Cancer Institute, Erasmus MC, 3015 GD Rotterdam, The Netherlands
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Daniëlle van Dorth Aachen C.J. Gorter MRI Center Department of Radiology, Leiden University Medical Center
Leiden University Medical Center
Affiliation as printed
C. J. Gorter MRI Center, Department of Radiology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands
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Erasmus MC · Erasmus MC Cancer Institute
Affiliation as printed
Department of Radiology and Nuclear Medicine, Erasmus MC, University Medical Center Rotterdam, 3015 GD Rotterdam, The Netherlands
Erasmus MC Cancer Institute, Erasmus MC, 3015 GD Rotterdam, The Netherlands
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Matthias J.P. van Osch Aachen C.J. Gorter MRI Center Department of Radiology, Leiden University Medical Center
Leiden University Medical Center
Affiliation as printed
C. J. Gorter MRI Center, Department of Radiology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands
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Erasmus MC · Erasmus MC Cancer Institute · Delft University of Technology
Affiliation as printed
Department of Medical Imaging, Faculty of Applied Physics, Delft University of Technology, 2628 CD Delft, The Netherlands
Department of Radiology and Nuclear Medicine, Erasmus MC, University Medical Center Rotterdam, 3015 GD Rotterdam, The Netherlands
Erasmus MC Cancer Institute, Erasmus MC, 3015 GD Rotterdam, The Netherlands
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Erasmus MC · Erasmus MC Cancer Institute
Affiliation as printed
Department of Radiology and Nuclear Medicine, Erasmus MC, University Medical Center Rotterdam, 3015 GD Rotterdam, The Netherlands
Erasmus MC Cancer Institute, Erasmus MC, 3015 GD Rotterdam, The Netherlands
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Dirk H. J. Poot corresponding
Erasmus MC · Erasmus MC Cancer Institute
Affiliation as printed
Department of Radiology and Nuclear Medicine, Erasmus MC, University Medical Center Rotterdam, 3015 GD Rotterdam, The Netherlands
Erasmus MC Cancer Institute, Erasmus MC, 3015 GD Rotterdam, The Netherlands
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