Multi-Scale Spiking Network Model of Human Cerebral Cortex

bioRxiv (Cold Spring Harbor Laboratory)

Abstract

Abstract Although the structure of cortical networks provides the necessary substrate for their neuronal activity, the structure alone does not suffice to understand it. Leveraging the increasing availability of human data, we developed a multi-scale, spiking network model of human cortex to investigate the relationship between structure and dynamics. In this model, each area in one hemisphere of the Desikan-Killiany parcellation is represented by a 1 mm 2 column with a layered structure. The model aggregates data across multiple modalities, including electron microscopy, electrophysiology, morphological reconstructions, and DTI, into a coherent framework. It predicts activity on all scales from the single-neuron spiking activity to the area-level functional connectivity. We compared the model activity against human electrophysiological data and human resting-state fMRI data. This comparison reveals that the model can reproduce aspects of both spiking statistics and fMRI correlations if the cortico-cortical connections are sufficiently strong. Furthermore, we show that a single-spike perturbation propagates through the network within a time close to the limit imposed by the delays.

Authors 8

1. Jari Pronold corresponding Aachen

   Forschungszentrum Jülich · Jülich Aachen Research Alliance · RWTH Aachen University

   Affiliation as printed

   Institute of Neuroscience and Medicine (INM-6) and Institute for Advanced Simulation (IAS-6) and JARA-Institute Brain Structure-Function Relationships (INM-10), Jülich Research Centre

   RWTH Aachen University

   Institute of Neuroscience and Medicine (INM-6) and Institute for Advanced Simulation (IAS-6) and JARA-Institute Brain Structure-Function Relationships (INM-0), Jülich Research Centre, 52428 Jülich, Germany

   RWTH Aachen University, 506 Aachen, Germany

2. Alexander van Meegen corresponding

   Forschungszentrum Jülich · University of Cologne · Jülich Aachen Research Alliance

   Affiliation as printed

   Institute of Neuroscience and Medicine (INM-6) and Institute for Advanced Simulation (IAS-6) and JARA-Institute Brain Structure-Function Relationships (INM-10), Jülich Research Centre

   Institute of Zoology, University of Cologne

   Institute of Neuroscience and Medicine (INM-6) and Institute for Advanced Simulation (IAS-6) and JARA-Institute Brain Structure-Function Relationships (INM-0), Jülich Research Centre, 52428 Jülich, Germany

   Institute of Zoology, University of Cologne, 50674 Cologne, Germany

3. Hannah Vollenbröker

   Forschungszentrum Jülich · Jülich Aachen Research Alliance · Heinrich Heine University Düsseldorf

   Affiliation as printed

   Heinrich Heine University Düsseldorf

   Institute of Neuroscience and Medicine (INM-6) and Institute for Advanced Simulation (IAS-6) and JARA-Institute Brain Structure-Function Relationships (INM-10), Jülich Research Centre

   Heinrich Heine University Düsseldorf, 0225 Düsseldorf, Germany

   Institute of Neuroscience and Medicine (INM-6) and Institute for Advanced Simulation (IAS-6) and JARA-Institute Brain Structure-Function Relationships (INM-0), Jülich Research Centre, 52428 Jülich, Germany

4. Renan O. Shimoura

   Forschungszentrum Jülich · Jülich Aachen Research Alliance

   Affiliation as printed

   Institute of Neuroscience and Medicine (INM-6) and Institute for Advanced Simulation (IAS-6) and JARA-Institute Brain Structure-Function Relationships (INM-10), Jülich Research Centre

   Institute of Neuroscience and Medicine (INM-6) and Institute for Advanced Simulation (IAS-6) and JARA-Institute Brain Structure-Function Relationships (INM-0), Jülich Research Centre, 52428 Jülich, Germany

5. Mario Senden

   Maastricht University

   Affiliation as printed

   Department of Cognitive Neuroscience, Faculty of Psychology and Neuroscience, Maastricht University

   Maastricht Brain Imaging Centre, Faculty of Psychology and Neuroscience, Maastricht University

   Department of Cognitive Neuroscience, Faculty of Psychology and Neuroscience, Maastricht University, 6229 ER Maastricht, The Netherlands

   Maastricht Brain Imaging Centre, Faculty of Psychology and Neuroscience, Maastricht University, 229 ER Maastricht, The Netherlands

6. Claus Christian Hilgetag

   Universität Hamburg · University Medical Center Hamburg-Eppendorf

   Affiliation as printed

   Institute of Computational Neuroscience, University Medical Center Eppendorf, Hamburg University

   Institute of Computational Neuroscience, University Medical Center Eppendorf, Hamburg University, 20246 Hamburg, Germany

7. Rembrandt Bakker

   Radboud University Nijmegen · Forschungszentrum Jülich · Jülich Aachen Research Alliance · Donders Institute for Brain, Cognition and Behaviour

   Affiliation as printed

   Donders Institute for Brain, Cognition and Behavior, Radboud University Nijmegen

   Institute of Neuroscience and Medicine (INM-6) and Institute for Advanced Simulation (IAS-6) and JARA-Institute Brain Structure-Function Relationships (INM-10), Jülich Research Centre

   Donders Institute for Brain, Cognition and Behavior, Radboud University Nijmegen, 6525 EN Nijmegen, The Netherlands

   Institute of Neuroscience and Medicine (INM-6) and Institute for Advanced Simulation (IAS-6) and JARA-Institute Brain Structure-Function Relationships (INM-0), Jülich Research Centre, 52428 Jülich, Germany

8. Sacha Jennifer van Albada corresponding

   Forschungszentrum Jülich · University of Cologne · Jülich Aachen Research Alliance

   Affiliation as printed

   Institute of Neuroscience and Medicine (INM-6) and Institute for Advanced Simulation (IAS-6) and JARA-Institute Brain Structure-Function Relationships (INM-10), Jülich Research Centre

   Institute of Zoology, University of Cologne

   Institute of Neuroscience and Medicine (INM-6) and Institute for Advanced Simulation (IAS-6) and JARA-Institute Brain Structure-Function Relationships (INM-0), Jülich Research Centre, 52428 Jülich, Germany

   Institute of Zoology, University of Cologne, 50674 Cologne, Germany