Magnesium Improves Cardiac Function in Experimental Uremia by Altering Cardiac Elastin Protein Content
Nutrients, vol. 15, pp. 1303
Abstract
Cardiovascular complications are accompanied by life-threatening complications and represent the major cause of death in patients with chronic kidney disease (CKD). Magnesium is important for the physiology of cardiac function, and its deficiency is common in CKD. In the present study, we investigated the impact of oral magnesium carbonate supplementation on cardiac function in an experimental model of CKD induced in Wistar rats by an adenine diet. Echocardiographic analyses revealed restoration of impaired left ventricular cardiac function in animals with CKD. Cardiac histology and real-time PCR confirmed a high amount of elastin protein and increased collagen III expression in CKD rats supplemented with dietary magnesium as compared with CKD controls. Both structural proteins are crucial in maintaining cardiac health and physiology. Aortic calcium content increased in CKD as compared with tissue from control animals. Magnesium supplementation numerically lowered the increases in aortic calcium content as it remained statistically unchanged, compared with controls. In summary, the present study provides evidence for an improvement in cardiovascular function and aortic wall integrity in a rat model of CKD by magnesium, as evidenced by echocardiography and histology.
Authors 10
-
Universitätsklinikum Aachen · Puigvert Foundation · RWTH Aachen University
Affiliation as printed
Division of Nephrology and Rheumatology, RWTH Aachen University Hospital, 52074 Aachen, Germany
Fundació Puigvert, 08025 Barcelona, Spain
-
Universitätsklinikum Aachen · RWTH Aachen University
Affiliation as printed
Division of Nephrology and Rheumatology, RWTH Aachen University Hospital, 52074 Aachen, Germany
-
Affiliation as printed
Department of Cardiology and Nephrology, Rhein-Maas Klinikum Würselen, 52146 Wuerselen, Germany
-
University of Southern Denmark · Institutul National Victor Babes · National Heart Centre Singapore
Affiliation as printed
Institute for Molecular Medicine, University of Southern Denmark, 5230 Odense, Denmark
National Heart Center Singapore, Singapore 169609, Singapore
“Victor Babes” National Institute of Pathology, 050096 Bucharest, Romania
"Victor Babes" National Institute of Pathology, 050096 Bucharest, Romania
-
Fresenius (Germany) · Fresenius Medical Care (Germany)
Affiliation as printed
Scientific Affairs, Center of Excellence Medical, Fresenius Medical Care Deutschland GmbH, 61352 Bad Homburg, Germany
-
Affiliation as printed
Institute for Experimental Molecular Imaging, RWTH Aachen, 52074 Aachen, Germany
-
Rafael Kramann Aachen Division of Nephrology and Rheumatology Institute of Experimental Medicine and Systems Biology
Universitätsklinikum Aachen · RWTH Aachen University
Affiliation as printed
Division of Nephrology and Rheumatology, RWTH Aachen University Hospital, 52074 Aachen, Germany
Institute of Experimental Medicine and Systems Biology, RWTH Aachen University Hospital, 52074 Aachen, Germany
-
Universitätsklinikum Aachen · RWTH Aachen University
Affiliation as printed
Division of Nephrology and Rheumatology, RWTH Aachen University Hospital, 52074 Aachen, Germany
-
Universitätsklinikum Aachen · RWTH Aachen University
Affiliation as printed
Division of Nephrology and Rheumatology, RWTH Aachen University Hospital, 52074 Aachen, Germany
-
Nadine Kaesler corresponding Aachen Division of Nephrology and Rheumatology Institute of Experimental Medicine and Systems Biology
Universitätsklinikum Aachen · RWTH Aachen University
Affiliation as printed
Division of Nephrology and Rheumatology, RWTH Aachen University Hospital, 52074 Aachen, Germany
Institute of Experimental Medicine and Systems Biology, RWTH Aachen University Hospital, 52074 Aachen, Germany
Cited by 0 stored of 0
No patents citing this paper on Lens.org (checked 2026-10-06).